Results 171 to 180 of about 314,968 (285)

Recent developments in the chemistry and enzyme inhibitory activity of fused thiazoles and thiadiazoles

Vietnam Journal of Chemistry, EarlyView.
Abstract The combination of cyclization reactions of thiadiazoles and benzothiazoles with Pd‐catalyzed cross‐coupling reactions provided a convenient synthesis of annulated, fluorinated and non‐fluorinated heterocycles, such as 1,3,4‐thiadiazolo[3,2‐a]pyrimidin‐5‐ones, benzothiazolo[3,2‐a]pyridimidin‐4‐ones, benzothiazolo[2,3‐b]quinazolin‐12‐ones and ...
Peter Langer
wiley   +1 more source

Glycine decarboxylase advances IgA nephropathy by boosting mesangial cell proliferation through the pyrimidine pathway. [PDF]

EMBO Mol Med
Xiong Y, Zeng F, Luo K, Wang L, Li M, Chen Y, Huang T, Xu C, Xu G, Zou H.   +9 more
europepmc   +1 more source

ESCA spectra and molecular charge distributions for some pyrimidine and purine bases [PDF]

, 1978
James Peeling, Frank E. Hruska, N. S. McIntyre   +2 more
openalex   +1 more source

Comparative in vitro studies on the immunosuppressive effects of purine and pyrimidine synthesis inhibitors. [PDF]

, 1993
Duquesnoy, RJ, Fung, JJ, Starzl, TE, Todo, S, Venkataramanan, R, Yao, GZ, Zeevi, A   +6 more
core  

Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer.

Cancer Discovery, 2017
K. Brown, J. Spinelli, J. Asara, A. Toker   +3 more
semanticscholar   +1 more source

Age Deceleration and Reversal Gene Patterns in Dauer Diapause

Aging Cell, EarlyView.
The dauer diapause is a naturally occurring extraordinarily long‐lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we define the processes underlying the slowed aging during dauer and the rejuvenation during exit.
Khrystyna Totska, João C. V. V. Barata, Walter Sandt, David H. Meyer, Björn Schumacher   +4 more
wiley   +1 more source

The deubiquitylase OTUB1 drives gemcitabine resistance in pancreatic cancer by enhancing pyrimidine metabolism through modulating DHODH mRNA stability. [PDF]

Cell Death Dis
Zhang W, Liu R, Hu J, Wan S, Zou Y, Che T, Zhang J, Chen L, Peng X.   +8 more
europepmc   +1 more source

Identification and evaluation of pyrimidine based CDK6 inhibitors against glioblastoma using integrated computational approaches [PDF]

Hina Manzoor, Muhammad Umer Khan, Raima Rehman, Chaudhry Ahmed Shabbir, Muhammad Ikram Ullah, Heba Bassiony Ghanem, Ayman Ali Mohammed Alameen, Muhammad Arshad Javed, Qurban Ali, Nazima Haider   +9 more
openalex   +1 more source

Canagliflozin Reprograms the Aging Hippocampus in Genetically Diverse UM‐HET3 Mice and Attenuates Alzheimer's‐Like Pathology

Aging Cell, EarlyView.
Canagliflozin enhances hippocampal function, reduces Aβ pathology, and improves cognitive function in male mice, while females show limited benefits, revealing sex‐specific neuroprotective responses across aging and Alzheimer's models. ABSTRACT Aging is the strongest risk factor for cognitive decline and Alzheimer's disease (AD), yet the mechanisms ...
Hashan Jayarathne, Dulmalika Herath Manchanayake, Ryan Sullivan, Nina Chimienti, Omar Kadri, Katherine Gurdziel, Seongho Kim, Hyejeong Jang, Brett C. Ginsburg, Richard A. Miller, Shoshana Yakar, Marianna Sadagurski   +11 more
wiley   +1 more source

Landscape analysis of m5C modification regulators unveils DNMT1-mediated dysregulated pyrimidine metabolism in hepatocellular carcinoma. [PDF]

Clin Epigenetics
Zhao X, Mao S, Fang Y, Chen J, Bi L, Li J, Wu J, Gao J, Yang S, Fu J, Wu X, Zhu G, Tang Z, Shi Y, Zhou J, Fan J, Zhang X, Jiang J, Liu W.   +18 more
europepmc   +1 more source