Results 171 to 180 of about 153,260 (279)

A one step synthetic approach to L-pyrimidine nucleosides using Natural Phosphate coated with potassium iodide as catalyst [PDF]

, 2008
Hassan B. Lazrek, Laila Baddi, Driss Ouzebla, Michaël Smietana, Jean‐Jacques Vasseur   +4 more
openalex   +1 more source

Inositol and Berberine Synergistically Reprogram Endocrine and Ovarian Metabolism in Polycystic Ovary Syndrome

Cell Proliferation, EarlyView.
In a DHEA+HFD‐induced mouse model, Ins/BBR alleviated mitochondrial defects and broadly reprogrammed metabolic landscape in granulosa cells, in specific, restoring nucleotide pools and amino acid turnover, and preventing abnormal long‐chain fatty acid accumulation.
Juan Ge, Chenxiang Zhang, Yilong Zhao, Haiyang Zhao, Shuai Zhu, Tao Tang, Guorui Zhang, Qiang Wang, Hui Wang   +8 more
wiley   +1 more source

Targeting DHODH reveals a metabolic vulnerability in AR-positive and AR-negative prostate cancer cells via pyrimidine synthesis and metabolic crosstalk with the TCA and urea cycles. [PDF]

Mol Metab
Labroy M, Paré MO, Berthiaume L, Thomas M, Jobin C, Veilleux A, Pelletier M, Pouliot F, Masson JY, Audet-Walsh É.   +9 more
europepmc   +1 more source

Heterologous plastoquinone production using a newly identified O2‐dependent cyanobacterial hydroxylase

The FEBS Journal, EarlyView.
In this study, we confirm that PlqH is the hydroxylase operating in plastoquinone biosynthesis in photosynthetic cyanobacteria (Cyanobacteriia). Our phylogenetic analyses demonstrate that cyanobacterial PlqH homologues originated from hydroxylases involved in ubiquinone biosynthesis in bacteria. Plastoquinone production in Escherichia coli was achieved
Morgane Roger‐Margueritat, Margot Beltran, Juliette Schnoebelen, Laura Flandrin, Wafa Rezali, Eline Michel, Sophie S. Abby, Fabien Pierrel   +7 more
wiley   +1 more source

Anticancer potential of fused heterocycles: structural insights and mechanistic advances. [PDF]

Asian Biomed (Res Rev News)
Pandey A, Sharma S, Kishore K, Rani S, Singh MV, Pemawat G.   +5 more
europepmc   +1 more source

Deletion of the <i>T</i>. <i>brucei CDA</i> gene induces pyrimidine auxotrophy.

, 2016
Leija Christopher, Rijo-Ferreira Filipa, N. Kinch Lisa, Grishin Nick V., Nicole Nischan, Kohler Jennifer J., Hu Zeping, Phillips Margaret A.   +7 more
openalex   +2 more sources

Plant organelle C‐to‐U RNA editing factors can operate successfully in yeast (Saccharomyces cerevisiae) as an easily amenable eukaryotic system for their functional analysis

The FEBS Journal, EarlyView.
Plant‐type pentatricopeptide repeat proteins capable of C‐to‐U RNA editing perform faithfully when expressed in a new heterologous system, the yeast Saccharomyces cerevisiae. They were tested with constitutive and inducible expression and with a set of different solubility tags. PPR56, PPR65, and PPR78 from P.
Shyam Ramanathan, Annika Hanraths, Jingchan Xie, Mareike Schallenberg‐Rüdinger, Volker Knoop   +4 more
wiley   +1 more source

Regioselective synthesis, structural investigation and binding behavior of 6-aroyl-7-aryl-5-methyl-4,7-dihydro-[1,2,4]triazolo[1,5-<i>a</i>]pyrimidines with BSA using various spectroscopic and <i>in silico</i> methods. [PDF]

RSC Adv
Aggarwal R, Sharma M, Sumran G, Kumar S, Kumar P.   +4 more
europepmc   +1 more source

Harnessing S. cerevisiae to advance the engineering of pentatricopeptide repeat proteins

The FEBS Journal, EarlyView.
Heterologous expression systems have been instrumental in furthering our understanding of plant RNA editing proteins. In this commentary, we discuss how the establishment of yeast as a model for studying plant RNA editing by Ramanathan et al. could advance the engineering of pentatricopeptide repeat proteins, and how in return pentatricopeptide repeat ...
Farley M. Kwok van der Giezen, Ian Small
wiley   +1 more source

Synthesis and antitumor property of triazole-aryloxyacetyl hydrazide hybrids with furo[2,3-d]pyrimidine scaffold. [PDF]

BMC Chem
Ma J, Zhao W, Gao H, Zhang B, Feng C, Hu Y.   +5 more
europepmc   +1 more source