Results 71 to 80 of about 314,968 (285)

Excited States of Proton-bound DNA/RNA Base Homo-dimers: Pyrimidines [PDF]

, 2014
We are presenting the electronic photo fragment spectra of the protonated pyrimidine DNA bases homo-dimers. Only the thymine dimer exhibits a well structured vibrational progression, while protonated monomer shows broad vibrational bands. This shows that
Adesokan A. a, Ahlrichs R., Alata I., Alata I., Alata I., Alata I., Andersen L. H., Bakker J. M., Berdakin M., Berdakin M., Bouchoux G., Boyarkin O. V., Brøndsted Nielsen S., Chakraborty S., Christophe Jouvet, Claude Dedonder-Lardeux, Delchev V. B., Dopfer O., Duncan M. A., Fonseca Guerra C., Fridgen T. D., Féraud G., Féraud G., Gehring K., Grégoire G., Gustavo A. Pino, Géraldine Féraud, Góra R. W., Hattig C., Kamrath M. Z., Kamrath M. Z., Kang H., Kang H., Kang H., Kleinermanns K., Le Barbu-Debus K., Lepere V., Lieblein A. L., Marian C., Matias Berdakin, Mercier S. R., Patzer A., Pino G. A., Rajabi K., Saigusa H., Salpin J.-Y., Schermann J.-P., Schirmer J., Scuderi D., Scuderi D., Sobolewski A. L., Solcà N., Wang X. B., Yang B., Yang B., Škríba A.   +55 more
core   +4 more sources

Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals

Aging, 2019
The pyrimidine metabolism pathway has important biological functions; it not only maintains appropriate pyrimidine pools but also produces bioactive intermediate metabolites.
Qin-Li Wan, Xiao Meng, Xiaodie Fu, Bohui Chen, Jing Yang, Hengwen Yang, Qinghua Zhou   +6 more
semanticscholar   +1 more source

Predicting MammaPrint Recurrence Risk from Breast Cancer Pathological Images Using a Weakly Supervised Transformer

Advanced Science, EarlyView.
This study presents CPMP, a weakly supervised transformer model that predicts MammaPrint recurrence risk directly from routine histopathological images of early‐stage HR+/HER2− breast cancer patients. CPMP enables spatial heatmap visualization, analysis of cellular‐level interaction patterns, and an in‐depth characterization of morphological phenotypes
Chaoyang Yan, Linwei Li, Xiaolong Qian, Yang Ou, Zhidong Huang, Zhihan Ruan, Wenting Xiang, Hong Liu, Jian Liu   +8 more
wiley   +1 more source

SLC6A14 Drives Mitochondrial Fusion and Oxidative Phosphorylation to Promote Cancer Stemness and Early‐Onset of Breast Cancer

Advanced Science, EarlyView.
Elevated levels of the plasticizer DEHP associate with earlier breast cancer diagnosis. DEHP enhances glutamine‐powered energy production via the transporter SLC6A14 and pushes mitochondria toward fusion, driving tumor initiation by boosting cancer stemness. Blocking SLC6A14 lowers stemness, slows tumors, and improves chemotherapy response.
Dai‐Wei Hu, Chih‐Hao Huang, Yu‐Hao He, Ya‐Ling Wei, Shu‐Wei Hu, Fang‐Ju Cheng, Thanh Kieu Huynh, Bo‐Rong Chen, Bo‐Wei Wang, Li‐Chi Kuan, Der‐Yen Lee, Ming‐Hsin Yeh, Ya‐Jen Chang, Liang‐Chih Liu, Mien‐Chie Hung, Wei‐Chien Huang   +15 more
wiley   +1 more source

Acceptor‐Bridged Engineering Enables Highly Efficient Solution‐Processed Pure‐Green MR‐TADF OLEDs With External Quantum Efficiency of 29% and Small Roll‐Off

Advanced Science, EarlyView.
Solution‐processible pure green multi‐resonance thermally activated delayed fluorescence (MR‐TADF) emitters are developed through a strategic acceptor‐bridging engineering approach that integrates MR‐building blocks with pyrimidine‐derived frameworks.
Xuming Zhuang, Qing Zhang, Jinbei Wei, Zhiqiang Li, Baoyan Liang, Chenguang Wang, Hai Bi, Yue Wang, Geyu Lu   +8 more
wiley   +1 more source

Diversion of aspartate in ASS1-deficient tumors fosters de novo pyrimidine synthesis

Nature, 2015
Cancer cells hijack and remodel existing metabolic pathways for their benefit. Argininosuccinate synthase (ASS1) is a urea cycle enzyme that is essential in the conversion of nitrogen from ammonia and aspartate to urea.
S. Rabinovich, Lital N Adler, Keren Yizhak, A. Sarver, Alon Silberman, Shani Agron, Noa Stettner, Qin Sun, A. Brandis, D. Helbling, S. Korman, S. Itzkovitz, D. Dimmock, I. Ulitsky, S. Nagamani, E. Ruppin, A. Erez   +16 more
semanticscholar   +1 more source

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, EarlyView.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source

Electron scattering from molecules and molecular aggregates of biological relevance [PDF]

, 2017
In this Topical Review we survey the current state of the art in the study of low energy electron collisions with biologically relevant molecules and molecular clusters.
Allan M, Allan M, Bouchiha D, Calegari F, Caprasecca S, Colyer C J, Colyer C J, da Costa R F, Denifl S, Dora A, Dubernet M L, Fabrikant I I, Fabrikant I I, Ferlay J, Fujimoto M M, Hall E, Herbert J M ed Parrill A L, Jensen F, Jimena D Gorfinkiel, Keller A, Linert I, Marangos J P, Nikjoo H, Ryszka M, Samukawa S, Slaughter D S, Surko C M, Sylwia Ptasinska, Trevisan C S, Vizcaino V, Winstead C, Zecca A, Zubek M, Ómarsson B   +33 more
core   +1 more source

Brain pyrimidine nucleotide synthesis and Alzheimer disease

Aging, 2019
Many patients suffering late-onset Alzheimer disease show a deficit in respiratory complex IV activity. The de novo pyrimidine biosynthesis pathway connects with the mitochondrial respiratory chain upstream from respiratory complex IV.
Alba Pesini, E. Iglesias, M. Bayona-Bafaluy, Nuria Garrido-Pérez, Patricia Meade, Paula Gaudó, Irene Jiménez-Salvador, P. Andrés‐Benito, J. Montoya, I. Ferrer, P. Pesini, E. Ruiz‐Pesini   +11 more
semanticscholar   +1 more source

The Vietnamese swine as a translational model of invasive ductal carcinoma of the breast

Animal Models and Experimental Medicine, EarlyView.
The flow diagram outlines the chemical induction of breast tumors through a single intraperitoneal dose of MNU. Tumor development was assessed using ultrasound and clinical examination. After 14 weeks, mammary tissue was collected and histologically analyzed to evaluate structural similarities between sows and humans, the carcinogenic potential of MNU,
Claudia Elizabeth Vera‐Tizatl, Arturo Vera‐Hernández, Lorenzo Leija‐Salas, Marco Antonio Vega‐López, María del Carmen Ramírez‐Estudillo, German Isauro Garrido Fariña, Adriana Leticia Vera‐Tizatl   +6 more
wiley   +1 more source