Results 71 to 80 of about 91,514 (181)

Integrated Chemoenzymatic Synthesis of the mRNA Vaccine Building Block N1‐Methylpseudouridine Triphosphate

Angewandte Chemie International Edition, Accepted Article.
Pseudouridine‐5’‐triphosphate (ΨTP) and the N1‐methylated derivative (m1ΨTP) are critical monomer building blocks of the currently used mRNA vaccines, yet efficient methods of their synthesis from readily accessible substrates remain underdeveloped. We herein report notably atom‐economic and high‐yielding biocatalytic route toward ΨTP (83% yield) and ...
Martin Pfeiffer, Leo Krammer, Johannes Zöhrer, Rolf Breinbauer, Bernd Nidetzky   +4 more
wiley   +1 more source

Metal‐Mediated Protein Engineering within Live Cells

Chemistry – An Asian Journal, Volume 20, Issue 6, March 17, 2025.
This review discusses how metal ions can mediate protein modification within live cells. With its easy handling, rapid solubility, and ease of internalization within the cells, metal ions can be an excellent stimulus for many organic reactions needed within an intracellular medium, which can modify proteins and lead to applications in chemistry ...
Pritam Ghosh
wiley   +1 more source

Visible Light‐Mediated Preparation of a Key Intermediate Employed in the Synthesis of Zolpidem and Several Analogs

Chemistry – An Asian Journal, EarlyView.
A new visible light‐induced method is reported for the C3‐alkylation of imidazo[1,2‐a]pyrimidines and ‐pyridines with aryldiazoacetates. This protocol can be performed in open air and serves as a convenient entry to several known and new molecules. A formal synthesis of zolpidem is achieved by changing the alkylating agent to an appropriate hypervalent
Ronei M. S. Souza, Tales A. C. Goulart, Roberto do C. Pinheiro, Felipe F. do C. Sonaglio, Deborah de A. Simoni, Rodrigo A. Cormanich, Igor D. Jurberg   +6 more
wiley   +1 more source

Feasibility and population exposure of 5‐fluorouracil using therapeutic drug monitoring (PREDICT‐5FU): A multicentre clinical trial

British Journal of Clinical Pharmacology, EarlyView.
Aim PREDICT‐5FU aimed to document 5‐fluorouracil (5FU) exposure in a cancer population and to evaluate the feasibility of 5FU and capecitabine therapeutic drug monitoring (TDM) in patients receiving standard doses and schedules. Methods Multicentre, prospective, observational single‐arm study.
Sarah Glewis, Michael Michael, Howard Gurney, Ian Olver, Nicholas Zdenkowski, Stephen Ackland, Craig Kukard, Madawa Jayawardana, S. Sandun M. Silva, Marliese Alexander, Jeanne Tie, Peter Galettis, Jennifer H. Martin   +12 more
wiley   +1 more source

RSEA: A Web Server for Pathway Enrichment Analysis of Metabolic Reaction Sets

Biotechnology and Bioengineering, EarlyView.
Reaction Set Enrichment Analysis (RSEA), a web server tool designed for metabolic pathway enrichment analysis of reaction sets derived from genome‐scale metabolic models was introduced. RSEA converts given reaction lists into standardized identifiers and statistically evaluates their enrichment across metabolic pathways.
Merve Yarıcı, Furkan Cantürk, Serdar Dursun, Hatice Nur Aydın, Muhammed Erkan Karabekmez   +4 more
wiley   +1 more source

N‐ to C‐Glycoside Rearrangement of Uridine 5′‐Phosphate in Two Enzymatic Steps for the Production of Pseudouridine 5′‐Phosphate

Biotechnology and Bioengineering, EarlyView.
The authors present a streamlined cascade reaction for one‐pot N‐C rearrangement of uridine‐5′‐phosphate (UMP) to pseudouridine‐5′‐phosphate (ΨMP; a key mRNA vaccine building block), in two enzymatic steps catalyzed by UMP nucleosidase (EC 3.2.2.10) and ΨMP C‐glycosidase (EC 4.2.1.70).
Martin Pfeiffer, Franziska Guld, Bernd Nidetzky   +2 more
wiley   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Synthesis and Metal‐Ion Binding Properties of Duplexes Containing Thymine Analogs with 1,2‐Diamine Groups

ChemBioChem, EarlyView.
The findings of thermal denaturation experiments indicate that duplexes containing thymine analogues with 1,2‐ethylenediamine side chains show stabilizing effects with five metal ions (e.g., Cu(II), Ni(II), Zn(II), Co(II), Cd(II)). The 1,2‐diamine side chain demonstrated to be useful as a new metal‐ion binding site.
Takahiro Atsugi, Shoji Fujiwara, Jiro Kondo, Akira Ono   +3 more
wiley   +1 more source

Purine and pyrimidine bases as growth substances for lactic acid bacteria [PDF]

, 1941
In 1936 Richardson (1) showed that uracil was essential for the anaerobic growth of Staphylococcus aureus, but not for aerobic growth of the same organism.
Mitchell, Herschel K., Snell, Esmond E.
core  

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, EarlyView.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source