Results 71 to 80 of about 151,536 (281)

The study of the antimicrobial activity of the derivatives of 6-(1,2,4-oxadizol-3-yl)- and 6-(2-aminothiazol-4-yl)thieno[2,3-d]pyrimidin-4-ones by the double dilution method

Журнал органічної та фармацевтичної хімії, 2019
Aim. To study profoundly the antimicrobial activity of the derivatives of 6-(1,2,4-oxadizol-3-yl)- and 6-(2-aminothiazol-4-yl)thieno[2,3-d]pyrimidin-4-ones by the double dilution method. Results and discussion. For the derivatives of 6-heterylthieno[2,3-
Sergiy V. Vlasov, Sergiy M. Kovalenko, T. P. Osolodchenko, V. S. Vlasov   +3 more
doaj   +1 more source

Synthetic Cathepsin B Sensitive Adjuvant‐Peptide Conjugates to Target Intracellular Toll‐Like Receptors 7 and 8

ChemistryEurope, EarlyView.
Cathepsin B‐sensitive peptide–adjuvant conjugates are designed, synthesized, and evaluated to deliver an antigenic peptid and an adjuvant targeting Toll‐like receptors 7 and 8 (TLR7/8) to antigen presenting cells. The adjuvant is released by cathepsin B resulting in antigen presentation and TLR mediated T cell activation.
Marjolein M. E. Isendoorn, Giulia Castello, Nico J. Meeuwenoord, Martijn Verdoes, Jeroen D. C. Codée, Ferry Ossendorp, Dmitri V. Filippov   +6 more
wiley   +1 more source

Covalent Attachment of a Platinum(II) Complex inside DNA Duplexes

ChemistryEurope, EarlyView.
Oxidative addition is used for the site‐specific incorporation of an organometallic PtII complex as an artificial nucleobase into a DNA duplex. The platination stabilizes the duplex and confers it with phosphorescence. An organometallic phosphorescent PtII complex is introduced into DNA duplexes via oxidative addition to a tailor‐made artificial ...
Tim Schäfer, Iván Maisuls, Felix Boisten, Marian Hebenbrock, Alexander Hepp, Cristian A. Strassert, Jens Müller   +6 more
wiley   +1 more source

The Hydrophilic Metabolite UMP Alleviates Obesity Traits through a HIF2α‐ACER2‐Ceramide Signaling Axis

Advanced Science
Metabolic abnormalities contribute to the pathogenesis of obesity and its complications. Yet, the understanding of the interactions between critical metabolic pathways that underlie obesity remains to be improved, in part owing to the lack of ...
Huiying Liu, Pengcheng Wang, Feng Xu, Qixing Nie, Sen Yan, Zhipeng Zhang, Yi Zhang, Changtao Jiang, Xiaomei Qin, Yanli Pang   +9 more
doaj   +1 more source

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, EarlyView.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source

Thioxopyrimidine in Heterocyclic Synthesis I: Synthesis of Some Novel 6-(Heteroatom-substituted)-(thio)pyrimidine Derivatives

Journal of Chemistry, 2013
A series of novel N-cycloalkanes, morpholine, piperazines, pyrazole, pyrimidine, benzimidazolo[1,2-a]pyrimidine, 1,2,3,4-tetrazolo[1,5-a]pyrimidine, azopyrazolo[1,5- a]pyrimidine, pyrimido[4', 5':3,4]pyrazolo[1,5-a]pyrimidines and pyridine derivatives ...
Yuh-Wen Ho, Maw Cherng Suen
doaj   +1 more source

Synthesis and Biological Activity of Pyrazolo[3,4-d]pyrimidine Derivatives Containing 1,3,4-Thiadiazole [PDF]

, 2012
Xin‐Jian Song, Yu Shao, Zhengcao Duan, Shirong Li   +3 more
openalex   +1 more source

Versatile Palladium‐Catalyzed C‐H Arylation of Fluoroarenes with 2‐Chloropyridine Derivatives

Chemistry – A European Journal, EarlyView.
Direct C─H arylation of fluoroarenes with 2‐chloropyridines is enabled by a simple Pd/SPhos system in isopropyl acetate. The method uses inexpensive reactants and shows broad scope and high yields. DFT computations explain reactivity and selectivity.
Federico Belnome, Péter P. Fehér, András Stirling, Csongor G. Németh, Tamás Hergert, György M. Keserű, Péter Ábrányi‐Balogh   +6 more
wiley   +1 more source

An efficient and targeted synthetic approach towards new highly substituted 6-amino-pyrazolo[1,5-a]pyrimidines with α-glucosidase inhibitory activity

, 2020
Fariba Peytam, Mehdi Adib, Reihaneh Shourgeshty, Loghman Firoozpour, Mahmoud Rahmanian-Jazi, Mehdi Jahani, Setareh Moghimi, Kouros Divsalar, Mohammad Ali Faramarzi, Somayeh Mojtabavi, Fatemeh Safari, Mohammad Mahdavi, Alireza Foroumadi   +12 more
openalex   +1 more source

Evolved DNAzymes and Stable Activation Chemistry Enable High‐Efficiency DNA Ligation

Chemistry – A European Journal, EarlyView.
In vitro selection of pre‐structured DNA libraries and chemical screening of alternative activation groups yielded trans‐acting DNAzymes with faster ligation rates and enhanced DNA substrate stability. The combination of C3S1 DNAzymes and phosphobenzimidazole‐activated DNA substrates provides improved DNA ligation performance, offering promise for ...
Connor Nurmi, Gemma Mendonsa, Mengdi Bao, Yingfu Li   +3 more
wiley   +1 more source