Results 111 to 120 of about 104,207 (331)
Studies on the Physiology of Pyrimidines. The Metabolism of the Pyrimidine Nucleosides
Experimental Biology and Medicine, 1929 The results of previous work by one of us1 indicated that the pyrimidines uracil and thymine, when fed in small amounts to dogs, are to a large extent metabolized. In the case of cytosine it was found that this substance was not utilized. It was partly excreted unchanged, partly deaminized and excreted in the form of uracil.These experiments were ...
O. H. Emerson, L. R. Cerecedo
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A Broadly Applicable Strategy to Aminate Azines Enabled by Electronically Tuned Phosphine Reagents
Angewandte Chemie International Edition, EarlyView.We have developed a pyridine C4‐amination reaction via phosphonium salt intermediates, where an electronically tuned phosphine is key to successful C─N bond formation. The process accommodates aliphatic amines, (heteroaryl)anilines, hydrazines, and nitrogen heteroaromatics, as well as a variety of pyridine building blocks and late‐stage C─N couplings ...
Ren‐Rong Liu +2 more
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RESEARCHES ON PYRIMIDINES: SYNTHESIS OF URACIL-4-ACETIC ACID. [PDF]
, 1908 Henry L. Wheeler, Leonard M. Liddle
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The Origin of the Feedstock Molecules for Life on the Hadean Earth
Angewandte Chemie International Edition, EarlyView.The origin of life in the Hadean eon required the formation of amino acids and nucleosides among the key molecules of life. In an often postulated strongly reducing atmosphere, HCN and its derivatives are robustly formed as plausible starting molecules. But HCN does not form in a Hadean, weakly reducing atmosphere.
Nikolai Diukarev +6 more
wiley +1 more source
Molecules, 2013 Aiming for the synthesis of new heterocyclic compounds containing a sulfonamido moiety suitable for use as antibacterial agents, the precursor ethyl {[4-N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenylazo}cyanoacetate was reacted with a variety of active ...
Eman A. El-Bordany +2 more
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Loss of TRIM21 drives UVB‐induced systemic inflammation by regulating DNA‐sensing pathways
Arthritis &Rheumatology, Accepted Article.Background Patients with systemic lupus erythematosus (SLE) experience photosensitivity, with exposure to ultraviolet light B (UVB) driving lupus flares and triggering symptoms like joint pain, fatigue, and cutaneous lesions. Although the mechanism(s) linking UVB exposure to systemic effects are unclear, type I interferons (IFNs) are known to play a ...
Gantsetseg Tumurkhuu +17 more
wiley +1 more source
Substrate identification of putative NCS1 and NCS2 nucleobase transporters in Pseudomonas aeruginosa
mBioPseudomonas aeruginosa is an opportunistic pathogen that can salvage nucleobases from the environment to conserve nutrients that would otherwise be spent on de novo nucleotide biosynthesis.
Corey Kennelly, Arthur Prindle
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Flowering in Fruit Trees and Annual Plants as Affected by Purines, Pyrimidines and Triiodobenzoic Acid. [PDF]
, 1959 B. Kessler, RPM Bak, A. Cohen
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Metal‐Mediated Protein Engineering within Live Cells
Chemistry – An Asian Journal, Volume 20, Issue 6, March 17, 2025.This review discusses how metal ions can mediate protein modification within live cells. With its easy handling, rapid solubility, and ease of internalization within the cells, metal ions can be an excellent stimulus for many organic reactions needed within an intracellular medium, which can modify proteins and lead to applications in chemistry ...
Pritam Ghosh
wiley +1 more source
BASIC ESTERS OF SUBSTITUTED PYRIMIDINE-4-CARBOXYLIC ACIDS [PDF]
, 1956 Gordon A. Grant +2 more
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