Results 111 to 120 of about 68,807 (327)

Purine and pyrimidine synthesis differently affect the strength of the inoculum effect for aminoglycoside and β-lactam antibiotics

Microbiology Spectrum
The inoculum effect has been observed for nearly all antibiotics and bacterial species. However, explanations accounting for its occurrence and strength are lacking.
Daniella M. Hernandez, Melissa Marzouk, Madeline Cole, Marla C. Fortoul, Saipranavi Reddy Kethireddy, Rehan Contractor, Habibul Islam, Trent Moulder, Ariane R. Kalifa, Estefania Marin Meneses, Maximiliano Barbosa Mendoza, Ruth Thomas, Saad Masud, Sheena Pubien, Patricia Milanes, Gabriela Diaz-Tang, Allison J. Lopatkin, Robert P. Smith   +17 more
doaj   +1 more source

Symmetry Analysis Of Genetic Code And Determinative Degree (in Russian) [PDF]

arXiv, 2000
A three-dimensional model of the genetic vocabulary is proposed in terms of determinative degree, an introduced characteristic of nucleotide, which reflects absolute difference between purin and pyrimidin bases in one DNA strand. In the fremework of this model manifest symmetry and group properties are described. It is proposed to use the determinative
arxiv  

Nonlinear Dynamics in the Binary DNA/RNA Coding Problem [PDF]

arXiv, 2001
The presence of low dimensional chaos in the protein secondary structures, using the binary coded $\alpha$-helices and $\beta$-sheet motifs, has been investigated. In order to analyse symbolic DNA/RNA sequences the assignment, based on the purine/pyrimidine and strong/wea k H - bond classification sheme, of binary numbers to the nucleotides was made ...
arxiv  

Harnessing molecular recognition for small molecule‐mediated, reversible photochemical control over mRNA translation

Angewandte Chemie International Edition, Accepted Article.
Chemical probes that control the function of complex RNA molecules offer unique opportunities to interrogate biological systems. In this study, we demonstrate that a small molecule ligand selectively recognizes and undergoes traceless, reversible photocrosslinking to PreQ1 RNA aptamers.
Shaifaly Parmar, Logan Tenney, Xiao Liang, John T. Routzahn, Christopher D. Sibley, John Schneekloth   +5 more
wiley   +1 more source

CHEMICAL CONSTITUENTS DERIVED FROM THE CANARIES MARINE SPONGE Myxilla sp.

Química Nova
Stigmasterols, ceramides, including ceramide-1-phosphates and pyrimidines were identified in an ethanol extract of the marine sponge Myxilla sp. The compounds were identified by MS and 1D- and 2D-NMR techniques.
Pere Ferriol Bunyola, Francisco J. Toledo Marante, Juan Francisco Leon Oyola, Ignacio Brouard Martin, Rayco Guedes Alonso, José J. Santana Rodríguez   +5 more
doaj   +1 more source

Lactic acid bacteria isolated from traditional Iranian butter with probiotic and cholesterol‐lowering properties: In vitro and in situ activity

Food Science &Nutrition, Volume 11, Issue 1, Page 350-363, January 2023., 2023
Traditional Iranian butter samples were collected from different parts of Iran and were screened for the presence of Lactic acid bacteria. The selected LAB were identified to species level by biphasic approach. The ability of selected LAB to lower the cholestrol both in vitro and in situ was then determined.
Mahbubeh Ostadzadeh, Mohammad B. Habibi Najafi, Mohammad R. Ehsani   +2 more
wiley   +1 more source

RESEARCHES ON PYRIMIDINES: SYNTHESIS OF CYTOSINE-5-ACETIC ACID. [FIFTY-FIRST PAPER.]¹ [PDF]

, 1911
Treat B. Johnson, Harley T. Peck, Joseph A. Ambler   +2 more
openalex   +1 more source

Regioselective C‐H Thio‐ and Selenocyanation of Pyrazolo[1,5‐a]pyrimidines

Chemistry – An Asian Journal, EarlyView.
A metal‐free, N‐chlorosuccinimide (NCS) mediated, highly efficient, and regioselective C−H thiocyanation and C−H selenocyanation of pyrazolo[1,5‐a]pyrimidines are achieved under mild reaction conditions for the synthesis of a wide variety of 3‐thiocyanato‐ and 3‐selenocyanatopyrazolo[1,5‐a]pyrimidines in good to excellent yield up to 99 %.
Paramita Pattanayak, Harshil Khandelwal, Shreeja Basappa, Tanmay Chatterjee   +3 more
wiley   +1 more source

Feasibility and population exposure of 5‐fluorouracil using therapeutic drug monitoring (PREDICT‐5FU): A multicentre clinical trial

British Journal of Clinical Pharmacology, EarlyView.
Aim PREDICT‐5FU aimed to document 5‐fluorouracil (5FU) exposure in a cancer population and to evaluate the feasibility of 5FU and capecitabine therapeutic drug monitoring (TDM) in patients receiving standard doses and schedules. Methods Multicentre, prospective, observational single‐arm study.
Sarah Glewis, Michael Michael, Howard Gurney, Ian Olver, Nicholas Zdenkowski, Stephen Ackland, Craig Kukard, Madawa Jayawardana, S. Sandun M. Silva, Marliese Alexander, Jeanne Tie, Peter Galettis, Jennifer H. Martin   +12 more
wiley   +1 more source

Study on combination therapy for lung cancer through pemetrexed‐loaded mesoporous polydopamine nanoparticles

Journal of Biomedical Materials Research Part A, Volume 111, Issue 2, Page 158-169, February 2023., 2023
Abstract Lung cancer is one of the most commonly diagnosed cancers, and surgical resection is the optimal choice for the primary lung tumor. But for the secondary lung cancer, chemotherapy and combined radiotherapy still are the main strategies. To realize the combined treatment for non‐small cell lung cancer (NSCLC), in this work, a nanoplatform based
Jian Xu, Wei Xu, Zhiqiang Wang, Yuequan Jiang   +3 more
wiley   +1 more source