Results 141 to 150 of about 104,207 (331)

Efficacy of DNA Intercalator‐Conjugated Triplex‐Forming Oligonucleotide as Anticancer Agent

ChemMedChem, Accepted Article.
A triplex‐forming oligonucleotide (TFO) can form a sequence‐specific triple helix via Hoogsteen hydrogen bonding to polypurine tracts within a major groove side of a DNA duplex. Triplex formation can induce a double‐strand break, and this phenomenon at the amplified gene loci can selectively induce the cell death of cancer cells with specific gene ...
Haruki Toyama, Akira Toriba, Atsushi Shibata, Takehiko Wada, Asako Yamayoshi, Yu Mikame   +5 more
wiley   +1 more source

Hydrazino Derivatives of Pyrimidine. V

, 1956
Den-itsu Shiho, SHOICHIRO TAGAMI, Noboru Takahayashi, Rikuko Honda   +3 more
openalex   +2 more sources

Development of Novel Anticancer Pyrazolopyrimidinones Targeting Glioblastoma

ChemMedChem, EarlyView.
Pyrazolo[1,5‐α]pyrimidinone derivatives exhibit selective cytotoxicity towards glioblastoma (GBM) cells over noncancerous cells. Structure–activity relationship studies identifies a lead compound with significant cytotoxicity activity, inducing apoptosis and necrosis in GBM cells, without affecting noncancerous cells. This demonstrates the potential of
Kate Byrne, Natalia Bednarz, Ciara McEvoy, John C. Stephens, James F. Curtin, Gemma K. Kinsella   +5 more
wiley   +1 more source

Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction

Molecules
The relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric ...
Marcos Díaz-Fernández, Manuel Algarra, Saturnino Calvo-Losada, José-Joaquín Quirante, Francisco Sarabia, María-Soledad Pino-González   +5 more
doaj   +1 more source

Cytotoxicity of Atropisomeric [1,1′‐Binaphthalene]‐2,2′‐Diamines (BINAM) and Analogs in Human Cancer Cells: Enantioselectivity, Structure–Activity Relationships, and Mechanism

ChemMedChem, EarlyView.
It is reported for the first time that atropisomeric (R)‐[1,1′‐binaphthalene]‐2,2′‐diamine (R‐BINAM, 1(R)), but not (S)‐[1,1′‐binaphthalene]‐2,2′‐diamine (S‐BINAM, 1(S)), is a moderately potent spindle poison, causing antiproliferation, depolymerization of microtubules, multipolar spindles, pericentriolar material (PCM) fragmentation, mitotic ...
Malte Eichelbaum, Patrick J. Bednarski
wiley   +1 more source

RESEARCHES ON PYRIMIDINES: PYRIMIDINE-NUCLEOSIDES

Journal of Biological Chemistry, 1913
Treat B. Johnson, Lewis H. Chernoff
openaire   +2 more sources

Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry

ChemMedChem, EarlyView.
This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali, Samet Poyraz, Samet Belveren, Senanur Taş, Mehmet Ali Tamer, Naciye Yaktubay Döndaş, H. Ali Döndaş, Jose Miguel Sansano   +7 more
wiley   +1 more source

Імуномодулюючі властивості нових фенілсульфонільних похідних піримідинових та піразоло[1,5-а]піримідинових основ

, 2008
Вивчено імуномодулюючий вплив нових фенілсульфонільних похідних піримідинових та піразоло[1,5-а]піримідинових основ на клітинні і гуморальні реакції та неспецифічну резистентність організму мишей.Изучено иммуномодулирующее влияние новых ...
Броварець, В.С., Драч, Б.С., Метелиця, Л.О., Могилевич, С.Є., Сливчук, С.Р., Чарочкіна, Л.Л.   +5 more
core  

Novel Pyrazolo [1,5‐a]−1,3,5‐Triazine Derivatives as CDK7 Inhibitors: Synthesis and Biological Insights in Pancreatic Ductal Adenocarcinoma Models

ChemMedChem, EarlyView.
Pyrazolo [1,5‐a]−1,3,5‐triazine derivatives efficiently synthesized showed remarkable cytotoxicity and inhibition of cell migration in PDAC models. They induced apoptosis, upregulated apoptotic gene expression, and disrupted the cell cycle, significantly reducing the viability of spheroidal PATU‐T cultures.
Daniela Carbone, Francesca Terrana, Ludovica Sciuto, Camilla Pecoraro, Geng Xu, Stella Cascioferro, Girolamo Cirrincione, Godefridus J. Peters, Elisa Giovannetti, Barbara Parrino, Patrizia Diana   +10 more
wiley   +1 more source

Formation of Enzymes Involved in Pyrimidine Synthesis and Amino Acid Metabolism in Escherichia coli

, 1958
Rose Sheinin
openalex   +1 more source