Results 11 to 20 of about 172,292 (284)
STUDIES IN PYRIMIDINE METABOLISM [PDF]
Journal of Biological Chemistry, 1920 By partial hydrolysis of yeast nucleic acid, preparations containing pyrimidines as the only nitrogenous constituents were prepared and administered to rabbits. Uracil nucleoside when administered per os, subcutaneously or intraperitoneally caused an increased excretion of urea often much more than enough to account for the nitrogen administered.
Darrell M. Wilson
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Pharmaceuticals, 2022 The objective of this review is to list the structures composed of a pyridopyrimidine moiety which have shown a therapeutic interest or have already been approved for use as therapeutics.
Joana F. Campos +2 more
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An overview on synthesis and biological activity of pyrimidines
World Journal of Advanced Research and Reviews, 2022 Pyrimidines represent an important class of heterocycles containing two nitrogen atoms at position 1 and 3 of the six membered ring show wide range of biological activities.
N. A. A. El-tawab +5 more
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Molecules, 2021 Pyrazolo[1,5-a]pyrimidine (PP) derivatives are an enormous family of N-heterocyclic compounds that possess a high impact in medicinal chemistry and have attracted a great deal of attention in material science recently due to their significant ...
Andres Arias-Gómez +2 more
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CuO/ZnO@N-GQDs@NH2 nanocomposite as superior catalyst for the synthesis of pyrimidine-triones [PDF]
Nanochemistry Research, 2021 CuO / ZnO@N - GQDs@NH2 nanocomposite (copper (II) oxide / zinc oxide @ Nitrogen-doped graphene quantum dots @ aminated) as superior catalyst has been applied for the synthesis of pyrimidine - trions by three-component reactions of N, N ...
Hossein Shahbazi-Alavi +2 more
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One‐pot and two‐pot methods for chalcone derived pyrimidines synthesis and applications
Journal of Heterocyclic Chemistry, 2021 Chalcone-derived pyrimidine is a well-known heterocyclic compound that is commonly present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio-isosteres.
S. Farooq, Z. Ngaini
semanticscholar +1 more source
Synthesis of pyrimidines using nano-NiZr4 (PO4)6 as a retrievable and robust heterogeneous catalyst [PDF]
Nanochemistry Research, 2020 Nano-NiZr4 (PO4)6 has been used as an effective and retrievable heterogeneous catalyst for the synthesis of pyrimidines through the reaction of benzaldehydes, guanidinehydrochloride and malononitrile under reflux conditions in ethanol.
Hossein Shahbazi-Alavi +1 more
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Molecules, 2023 The present work describes the design and development of seventeen pyrimidine-clubbed benzimidazole derivatives as potential dihydrofolate reductase (DHFR) inhibitors.
M. Akiful Haque +11 more
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Design and Synthesis of New Pyrimidine-Quinolone Hybrids as Novel hLDHA Inhibitors
Pharmaceuticals, 2022 A battery of novel pyrimidine-quinolone hybrids was designed by docking scaffold replacement as lactate dehydrogenase A (hLDHA) inhibitors. Structures with different linkers between the pyrimidine and quinolone scaffolds (10-21 and 24–31) were studied in
Iván Díaz +3 more
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Computational Estimation of the Acidities of Pyrimidines and Related Compounds
Molecules, 2022 Pyrimidines are key components in the genetic code of living organisms and the pyrimidine scaffold is also found in many bioactive and medicinal compounds. The acidities of these compounds, as represented by their pKas, are of special interest since they
Rachael A. Holt, Paul G. Seybold
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