Results 11 to 20 of about 72,841 (281)

Synthesis of pyrimidines by Fe3O4@SiO2-L-proline nanoparticles

Main Group Metal Chemistry, 2020
Fe3O4@SiO2-L-proline nanoparticles have been used as an effective catalyst for the preparation of pyrimidines by three-component reactions of 1,3-dimethylbarbituric acid, aromatic aldehydes and 4-methyl aniline or 4-methoxy aniline under reflux condition
Safaei-Ghomi Javad, Samadi Zahra
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Design and Synthesis of New Pyrimidine-Quinolone Hybrids as Novel hLDHA Inhibitors

Pharmaceuticals, 2022
A battery of novel pyrimidine-quinolone hybrids was designed by docking scaffold replacement as lactate dehydrogenase A (hLDHA) inhibitors. Structures with different linkers between the pyrimidine and quinolone scaffolds (10-21 and 24–31) were studied in
Iván Díaz, Sofia Salido, Manuel Nogueras, Justo Cobo   +3 more
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Fighting Antibiotic Resistance: New Pyrimidine-Clubbed Benzimidazole Derivatives as Potential DHFR Inhibitors

Molecules, 2023
The present work describes the design and development of seventeen pyrimidine-clubbed benzimidazole derivatives as potential dihydrofolate reductase (DHFR) inhibitors.
M. Akiful Haque, Akash Marathakam, Ritesh Rana, Samar J Almehmadi, Vishal B. Tambe, Manoj S. Charde, Fahadul Islam, Falak A. Siddiqui, Giulia Culletta, Anna Maria Almerico, Marco Tutone, Sharuk L. Khan   +11 more
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Sonosynthesis of Pyrimidines as Antimicrobial Agents Using Nano-Fe3O4–L-cysteine [PDF]

Nanochemistry Research, 2022
Nano-Fe3O4–L-cysteine as a superior catalyst was applied for the synthesis of pyrimidine-trions by three-component reactions of N,N-dimethylbarbituric acid, benzaldehydes and para-methyl aniline or para-methoxy aniline under ultrasonic irradiation in ...
Hossein Shahbazi-Alavi, Javad Safaei-Ghomi   +1 more
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Triethylamine-Promoted Oxidative Cyclodimerization of 2H-Azirine-2-carboxylates to Pyrimidine-4,6-dicarboxylates: Experimental and DFT Study

Molecules, 2023
An unprecedented oxidative cyclodimerization reaction of 2H-azirine-2-carboxylates to pyrimidine-4,6-dicarboxylates under heating with triethylamine in air is described. In this reaction, one azirine molecule undergoes formal cleavage across the C-C bond
Timofei N. Zakharov, Pavel A. Sakharov, Mikhail S. Novikov, Alexander F. Khlebnikov, Nikolai V. Rostovskii   +4 more
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The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus

Journal of Fungi, 2020
The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH).
Saskia du Pré, Mike Birch, Derek Law, Nicola Beckmann, Graham E. M. Sibley, Michael J. Bromley, Nick D. Read, Jason D. Oliver   +7 more
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In Silico Screening of the Library of Pyrimidine Derivatives as Thymidylate Synthase Inhibitors for Anticancer Activity

E-Journal of Chemistry, 2009
We here report the virtual screening of several series of pyrimidine derivatives for in silico Thymidylate Synthase (TS) inhibition to arrive at possible potential inhibitors of TS with acceptable pharmacokinetic or ADME (Absorption, Distribution ...
A. G. Nerkar, S. A. Ghone, A. K. Thaker
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C–C (alkynylation) vs C–O (ether) bond formation under Pd/C–Cu catalysis: synthesis and pharmacological evaluation of 4-alkynylthieno[2,3-d]pyrimidines

Beilstein Journal of Organic Chemistry, 2011
The Pd/C–CuI–PPh3 catalytic system facilitated C–C bond formation between 4-chlorothieno[2,3-d]pyrimidines and terminal alkynes in methanol with high selectivity without generating any significant side products arising from C–O bond formation between the
Dhilli Rao Gorja, K. Shiva Kumar, K. Mukkanti, Manojit Pal   +3 more
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Comparative assessment of stability of fungicides triazolopyrimidine, triazole, pyrimidine and morpholine in the soil and prediction of groundwater pollution with them.

Medičnì Perspektivi, 2016
The purpose of our study was prediction of ground water contamination with fungicides of different chemical classes in soil-climatic conditions of Ukraine and other European countries and hygienic assessment of their harmful effects on human health.
S. V. Bіlous, S. T. Omel'chuk, O. P. Vavrіnevich, A. M. Antonenko   +3 more
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Synthesis, characterisation and biological activities of N-phenyl-ethan-1-one-2,4-dimethyl-1,3-butadiene-1,4-thiazin derivatives

Tikrit Journal of Pure Science, 2023
A facile synthesis of some new 1, 2- thiazine derivatives by the Claisen-Schmidt reaction-induced aldolic condensation of enolizable aromatic ketones with substituted benzaldehydes, and then they were treated with urea and thiourea to obtain the ...
Nabaz Abdulmajeed Mohammad Salih
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