Results 71 to 80 of about 68,807 (327)
Temperature and Tautomeric Effects in High-Resolution Oxygen 1s X-ray Photoelectron Spectroscopy of Purines and Pyrimidines [PDF]
J. Chem. Phys. 161, 104303 (2024)Purines and pyrimidines, crucial building blocks in biological systems, have attracted significant interest across molecular physics, biochemistry, pharmacology, and chemistry. Extensive spectroscopies have been employed for characterization, while the temperature and potential tautomeric effects can complicate the interpretation of underlying physics ...
arxiv +1 more source
RFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma
Advanced Science, EarlyView.RFWD3 is identified as a key regulator of cisplatin (DDP) sensitivity in osteosarcoma using a genome‐wide CRISPR screen. RFWD3 promotes PHGDH ubiquitination, enhancing NAD+‐mediated nucleotide biosynthesis. Knocking out RFWD3 sensitized osteosarcoma cells to DDP.
Wenchao Zhang +6 more
wiley +1 more source
Electron Spin Resonance in sine-Gordon spin chains in the perturbative spinon regime [PDF]
, 2005 We report the low-temperature multi-frequency ESR studies of copper pyrimidine dinitrate, a spin-1/2 antiferromagnetic chain with alternating $g$-tensor and the Dzyaloshinskii-Moriya interaction, allowing us to test a new theoretical concept proposed recently by Oshikawa and Affleck [Phys. Rev. Lett. 82, 5136 (1999)].
arxiv +1 more source
Self‐Induced A‐B‐A Structure Enables Efficient Wide‐Bandgap Perovskite Solar Cells and Tandems
Advanced Science, EarlyView.DMFP penetrates to the bottom of the perovskite, forming an A‐B‐A sandwich structure with BzMIM Br, leading to strong interactions with the perovskite. In the vertical direction, utilizing multisite coordination with Pb ions forms internal molecular bridges, which not only improves crystallographic orientation but also suppresses halide phase ...
Xixi Yu +10 more
wiley +1 more source
A Comparative Experimental and Theoretical Study on Doubly Differential Electron-Impact Ionization Cross Sections of Pyrimidine [PDF]
To provide a comprehensive data set for track structure-based simulations of radiation damage in DNA, doubly differential electron-impact ionization cross sections of pyrimidine, a building block of the nucleobases cytosine and thymine, were measured for primary electron energies between 30 eV and 1 keV as a function of emission angle and secondary ...
arxiv +1 more source
Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration
Advanced Science, EarlyView.The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan +16 more
wiley +1 more source
Angewandte Chemie, EarlyView.An efficient artificial copper‐dependent Michaelase featuring a metal‐binding unnatural amino acid, e. g. bipyridyl alanine (BpyA), was optimized through directed evolution and applied in catalytic asymmetric additions of 2‐acetyl azaarenes to nitroalkenes.
Ru Jiang +3 more
wiley +2 more sources
The Latest Advances in Mechanically Robust Self‐Healing Polyurea Based on Dynamic Chemistry
Advanced Science, EarlyView.Solving the contradiction between strength, toughness, and self‐healing properties is extremely important to realize the breakthrough of polyurea applications. This review summarizes and discusses common strategies for the preparation of high‐performance and self‐healing polyurea materials based on dynamic chemistry, providing molecular‐level insights ...
Yujia Hao, Guangming Zhu
wiley +1 more source
“Naked Nickel”‐Catalyzed Heteroaryl–Heteroaryl Suzuki–Miyaura Coupling
Angewandte Chemie, EarlyView.We report that an air‐stable “naked nickel”, Ni(4‐CF3stb)3, can efficiently catalyze heteroaryl–heteroaryl Suzuki–Miyaura cross‐coupling (SMC) reactions in the absence of exogenous ligands. This protocol permits the construction of >15 different heterobiaryls containing multiple Lewis basic heteroatoms from a broad set of 6‐membered heteroaryl bromides
Rakan Saeb, Byeongdo Roh, Josep Cornella
wiley +2 more sources
Recent Advances in Pyrimidine-Based Drugs
PharmaceuticalsPyrimidines have become an increasingly important core structure in many drug molecules over the past 60 years. This article surveys recent areas in which pyrimidines have had a major impact in drug discovery therapeutics, including anti-infectives ...
Baskar Nammalwar, Richard A. Bunce
doaj +1 more source