Results 71 to 80 of about 172,292 (284)

Solvable models of neighbor-dependent nucleotide substitution processes

, 2005
We prove that a wide class of models of Markov neighbor-dependent substitution processes on the integer line is solvable. This class contains some models of nucleotide substitutions recently introduced and studied empirically by molecular biologists.
Bérard, Jean, Gouéré, Jean-Baptiste, Piau, Didier   +2 more
core   +3 more sources

Dizajniranje i sinteza novih derivata tiofenkarbohidrazida, tienopirazola i tienopirimidina s antioksidativnim i antitumorskim djelovanjem [PDF]

, 2010
2-Amino-5-acetyl-4-methyl-thiophene-3-carboxylic acid ethyl ester (1) and 5-acetyl-2-amino-4-methylthiophene-3-carbohydrazide (2) were synthesized and used as starting materials for the synthesis of new series of 1-(5-amino-4-(3,5-dimethyl-1H-pyrazole-1 ...
A. El-Gazzar, A. El-Gazzar, A. El-Gazzar, A. Rosowsky, Ameen Abu-Hashem, E. Lissi, Farid Badria, G. Nikolakopoulos, H. Hafez, H. Lütjens, I. Heiba, K. Dore, K. Gewald, K. Ghakraborti, L. Aurelio, M. Nassan, Mohamed El-Shehry, R. Aeschlach, R. Jarvest, S. Sasaki, T. Brown, T. Fujita, V. Alagarsamy, W. Lichen, Y. Morimoto   +24 more
core   +3 more sources

Crystal structure of 5-[bis(methylsulfonyl)methyl]-1,3-dimethyl-5-(methylsulfonyl)pyrimidine-2,4,6(1H,3H,5H)-trione

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C10H16N2O9S3, the pyrimidine ring of the 1,3-dimethyl barbituric acid moiety has an envelope conformation with the C atom carrying the methylsulfonyl and bis(methylsulfonyl)methyl substituents as the flap.
Eyad Mallah, Ahmed Al-Sheikh, Kamal Sweidan, Wael Abu Dayyih, Manfred Steimann   +4 more
doaj   +1 more source

Maximum principle and mutation thresholds for four-letter sequence evolution [PDF]

, 2004
A four-state mutation-selection model for the evolution of populations of DNA-sequences is investigated with particular interest in the phenomenon of error thresholds.
Baake E, Baake E, Bürger R, Charlesworth B, Drake J W, Eigen M, Jukes T H, Karlin S, Kemeny J G, Kimura M, Kimura M, Leuthäusser I, Maynard Smith J, Ohta T, Swofford D L, Tarazona P, van Lint J H   +16 more
core   +4 more sources

Purine and pyrimidine synthesis differently affect the strength of the inoculum effect for aminoglycoside and β-lactam antibiotics

Microbiology Spectrum
The inoculum effect has been observed for nearly all antibiotics and bacterial species. However, explanations accounting for its occurrence and strength are lacking.
Daniella M. Hernandez, Melissa Marzouk, Madeline Cole, Marla C. Fortoul, Saipranavi Reddy Kethireddy, Rehan Contractor, Habibul Islam, Trent Moulder, Ariane R. Kalifa, Estefania Marin Meneses, Maximiliano Barbosa Mendoza, Ruth Thomas, Saad Masud, Sheena Pubien, Patricia Milanes, Gabriela Diaz-Tang, Allison J. Lopatkin, Robert P. Smith   +17 more
doaj   +1 more source

Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt

Beilstein Journal of Organic Chemistry, 2020
A synthesis of fluorinated pyrimidines under mild conditions from amidine hydrochlorides and the recently described potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained.
Tobias Lucas, Jule-Philipp Dietz, Till Opatz   +2 more
doaj   +1 more source

CHEMICAL CONSTITUENTS DERIVED FROM THE CANARIES MARINE SPONGE Myxilla sp.

Química Nova
Stigmasterols, ceramides, including ceramide-1-phosphates and pyrimidines were identified in an ethanol extract of the marine sponge Myxilla sp. The compounds were identified by MS and 1D- and 2D-NMR techniques.
Pere Ferriol Bunyola, Francisco J. Toledo Marante, Juan Francisco Leon Oyola, Ignacio Brouard Martin, Rayco Guedes Alonso, José J. Santana Rodríguez   +5 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of PKD Inhibitors

Pharmaceutics, 2011
Protein kinase D (PKD) belongs to a family of serine/threonine kinases that play an important role in basic cellular processes and are implicated in the pathogenesis of several diseases.
Marie-Céline Frantz, Karla Bravo-Altamirano, Courtney R. LaValle, Manuj Tandon, Stephanie Leimgruber, Elizabeth R. Sharlow, John S. Lazo, Q. Jane Wang, Peter Wipf, Kara M. George   +9 more
doaj   +1 more source

Microwave assisted synthesis and antimicrobial activity of some novel pyrimidine derivatives [PDF]

Journal of the Serbian Chemical Society, 2007
The synthesis of thiazolo[5,4-d]pyrimidines can be achieved from different 5- thiazolidinones, 2-butyl-1H-imidazole-5-carbaldehyde and thiourea using microwave irradiation within 5 min.
Vaghasia S.J., Shah V.H.
doaj   +1 more source

Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles

Molecules, 2010
The synthesis of the title compounds was achieved using ethyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (1) as starting material.
Hussein El-Kashef, Abdel-Rahman Farghaly, Ahmed Al-Hazmi, Thierry Terme, Patrice Vanelle   +4 more
doaj   +1 more source