Results 161 to 170 of about 3,593 (197)

Pyrimidinones as biodynamic agents

1987
In view of the diverse types of biological activities associated with pyrimidinones and molecules having pyrimidinone as a component substructure, the pyrimidinone moiety may be considered as an important pharmacophore for incorporation in the design of molecules of biological interest.
A K, Saxena, S, Sinha
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ChemInform Abstract: New Pyrimidinone and Fused Pyrimidinone Derivatives as Potential Anticancer Chemotherapeutics.

ChemInform, 2013
AbstractA series of new pyrimidinone derivatives is synthesized starting from oxiranyl aryl ketone (I).
Aymn E. Rashad, Ahmed H. Shamroukh, Nabil M. Yousif, Mowafia A. Salama, Hatem S. Ali, Mamdouh M. Ali, Abeer E. Mahmoud, Mahmoud El‐Shahat   +7 more
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Pyrimidinones. 1. 2-Amino-5-halo-6-aryl-4(3H)-pyrimidinones. Interferon-inducing antiviral agents

Journal of Medicinal Chemistry, 1985
Interferon induction and antiviral activity was discovered with 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone. An analogue study incorporating a series of 2-amino-5-substituted-6-arylpyrimidinones revealed that the most potent interferon inducers were mono- and difluorophenyl analogues.
H I, Skulnick, S D, Weed, E E, Eidson, H E, Renis, W, Wierenga, D A, Stringfellow   +5 more
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Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribosides

Journal of Medicinal Chemistry, 1985
1-(2-Deoxy-beta-D-ribofuranosyl)-5-bromo-2-pyrimidinone (BrPdR) and 1-(2-deoxy-beta-D-ribofuranosyl)-5-iodo-2-pyrimidinone (IPdR) have been synthesized by condensation of the appropriate silylated bases 2a and 2b, respectively, with 3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-alpha-D-ribofuranosyl chloride (8) in 1,2-dichloroethane, in the presence of SnCl4 ...
S M, Efange, E M, Alessi, H C, Shih, Y C, Cheng, T J, Bardos   +4 more
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Fluorescent 2‐Pyrimidinone Nucleoside in Parallel‐Stranded DNA

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Kaluzhny, D., Mikhailov, S., Efimtseva, E., Borisova, O., Florentiev, V., Shchyolkina, A., Jovin, T.   +6 more
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ChemInform Abstract: Pyrimidinones. Part 1. 2‐Amino‐5‐halo‐6‐aryl‐4(3H)‐pyrimidinones.

Chemischer Informationsdienst, 1986
AbstractDie aus dem Halbester (I) zugänglichem Pyrimidinone (V) besitzen Interferon‐induzierende und antivirale Wirkung.
H. I. SKULNICK, S. D. WEED, E. E. EIDSON, H. E. RENIS, W. WIERENGA, D. A. STRINGFELLOW   +5 more
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ChemInform Abstract: Photochemistry of 4‐Pyrimidinones. Part 7. Reaction of Dewar 4‐Pyrimidinone with Methylamine.

Chemischer Informationsdienst, 1982
AbstractDie Photolyse der Pyrimidinone (I) in flüssigem Methylamin (II) führt zu den offenkettigen Produkten (III), die bei der Chromatographie an Aluminiumoxid zu den Pyrimidinonen (IV) cyclisieren.
Y. HIRAI, H. KANMEI, T. YAMAZAKI, S. HIROKAMI   +3 more
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Pyrimidinone Antibiotics—Heterocyclic Analogues with Improved Antibacterial Spectrum.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Michael, Brands, Yolanda Cancho, Grande, Rainer, Endermann, Reinhold, Gahlmann, Jochen, Krüger, Siegfried, Raddatz   +5 more
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Antineoplastic properties of pyrimidinone interferon inducers

Advances in Enzyme Regulation, 1981
Abstract The interferon inducing, antiviral and antitumor activities of a new series of pyrimidinone compounds are compared and summarized in this report. An interesting split in mechanism of action appeared to exist in these compounds. One group represented by ABPP were very potent interferon inducing agents and the antiviral and antitumor activity ...
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Conformation of 1,2,3,4-tetrahydro-2-pyrimidinones

Chemistry of Heterocyclic Compounds, 1981
The conformation of a number of 1,2,3,4-tetrahydro-2-pyrimidinones with various substituents in the ring was established on the basis of the vicinal 3J34 constants found from the 1H NMR spectra of these compounds. It is shown that in solution rapid conformational transformations between the two possible “boat” conformations evidently occur.
�. �. Liepin'sh, E. L. Khanina, G. Ya. Dubur   +2 more
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