Results 171 to 180 of about 3,593 (197)
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Pyrimidinones as reversible metaphase arresting agents
European Journal of Medicinal Chemistry, 1993Abstract 5-Halo- N (1)-substituted 2(1 H )-pyrimidinones have the ability to cause reversible arrest of mitosis during metaphase. Highly active compounds have a heteroatom ( O , S or N ) in the β-position of the N (1)-carbon chain which is further substituted by an aryl group. In vitro data have been provided.
T Benneche +3 more
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Phenylation of pyrimidinones using diphenyliodonium salts
Journal of the Chemical Society, Perkin Transactions 1, 1999Pyrimidinones 1 have been phenylated under basic conditions using diphenyliodonium salts, and the effect of substituents on the yield and regiochemistry has been studied.
Stig André Jacobsen +2 more
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Interferon Induction by 5-Halo-6-Phenyl Pyrimidinones
Journal of Interferon Research, 1980The interferon inducing characteristics of a new series of 6-phenyl pyrimidinol compounds are described and compared against a previously identified pyrimidine, 2-amino-5-bromo-6-methyl-4-pyrimidinol (ABMP). Interestingly, a split in ability to induce interferon but not in vivo antiviral activity was observed in the newest compounds. One representative
D A, Stringfellow +2 more
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4-Azido-2-pyrimidinone Nucleosides and Related Chemistry
The Journal of Organic Chemistry, 1997As a part of azide prodrug approach, we synthesized a 4-azido analog of ara-C (4) as a prodrug for ara-C. The compound 4 was obtained from 1-(beta-D-arabinofuranosyl)uracil (1) in three steps. At pH 7.0 and 11.0, a loss of UV absorption of the compound 4 was observed resulting from a transformation that was proved by identifying the transformed product
Lakshmi P., Kotra +7 more
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Syntheses of trifluoromethylated pyridinones and pyrimidinones
The Journal of Organic Chemistry, 1990Les syntheses s'effectuent via la reaction d'orthoformiates avec des enaminonitriles ou avec des ...
Len F. Lee, Y. Larry Sing
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ChemInform Abstract: Synthesis of Fluorinated Pyrimidinones.
ChemInform, 2013AbstractFluorinated pyrimidinones are constructed in two steps from cyanodifluoromethyl‐substituted amines and isocyanates.
Mikhail D. Kosobokov +4 more
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Synthesis, 2012
Pivalic acid is a useful medium to effect the direct SNAr displacement of 2-methylthio-4-pyrimidinones with a variety of anilines. Products are easily isolated in good to excellent yields, and following chlorination, provide an opportunity to rapidly query structure-activity relationships at the 4-position of functionalized pyrimidines.
Matthew Maddess, Rhiannon Carter
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Pivalic acid is a useful medium to effect the direct SNAr displacement of 2-methylthio-4-pyrimidinones with a variety of anilines. Products are easily isolated in good to excellent yields, and following chlorination, provide an opportunity to rapidly query structure-activity relationships at the 4-position of functionalized pyrimidines.
Matthew Maddess, Rhiannon Carter
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(E)- and (Z)-Enamine Dewar Pyrimidinones
Acta Crystallographica Section C Crystal Structure Communications, 1995The structures of (E)- and (Z)-methyl 1,6-dimethyl-5-oxo-2,6-diazabicyclo[2.2.0]hex-3-ylideneacetate, C 9 H 12 N 2 O 3 , have been established by X-ray diffraction analyses. The 2-azetidinone ring, azetidine ring and enamine moiety in both isomers are quite planar.
H. Kakuda, Y. Takahashi, S. i. Hirokami
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New morpholine-containing pyrimidinones act on α-adrenoceptors
European Journal of PharmacologyDrugs that act on α-adrenoceptors may contain morpholine and pyrimidinone heterocycles. The aim of this study was to synthesize a series of pyrimidinones (S6a-e and S8) and characterize their α-adrenoceptor activity. Cytotoxicity assays (MTT and LDH) were performed in A7r5 and HUVECs. Concentration-effect curves to phenylephrine (Phe) were performed in
Silvia Maria de Luna Alves +10 more
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