Results 41 to 50 of about 4,994 (242)

Efficient synthesis, reactions and spectral characterization of pyrazolo[4’,3’:4,5]thieno[3,2-d] pyrimidines and related heterocycles

Heterocyclic Communications, 2019
New pyrazolothienopyrimidines were synthesized. The key intermediate 4-aminothieno[2,3-c]pyrazole-5-carbonitrile 1 was converted to the chloroacetyl amino derivative 2 followed by nucleophilic substitution and Dimorth rearrangement upon treatment with ...
Zaki Remon M., Kamal El-Dean Adel M., Radwan Shaban M., Saber Ahmed F.   +3 more
doaj   +1 more source

Evaluation of Neurotropic Activity and Molecular Docking Study of New Derivatives of pyrano[4″,3″:4′,5′]pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines on the Basis of pyrano[3,4-c]pyridines

Molecules, 2022
Background: Heterocyclic compounds and their fused analogs, which contain pharmacophore fragments such as pyridine, thiophene and pyrimidine rings, are of great interest due to their broad spectrum of biological activity.
Shushanik Sh. Dashyan, Eugene V. Babaev, Ervand G. Paronikyan, Armen G. Ayvazyan, Ruzanna G. Paronikyan, Lernik S. Hunanyan   +5 more
doaj   +1 more source

Controlling Intestinal Organoid Polarity using Synthetic Dynamic Hydrogels Decorated with Laminin‐Derived IKVAV Peptides

Advanced Healthcare Materials, EarlyView.
Design rules are presented to control intestinal organoid polarity in fully synthetic hydrogels. The laminin‐derived IKVAV sequence is crucial to obtain correct intestinal organoid polarity. Increasing hydrogel dynamics further supports the growth of correctly polarized intestinal organoids, while a bulk level of stiffness (G’ ≈ 0.7 kPa) is crucial to ...
Laura Rijns, Joost A. P. M. Wijnakker, Victor A. Veenbrink, Riccardo Bellan, Fenna W. B. Craenmehr, Simone I. S. Hendrikse, Johnick F. van Sprang, Wim de Lau, E. W. Meijer, Hans Clevers, Patricia Y. W. Dankers   +10 more
wiley   +1 more source

Optimization of Anti-kinking Designs for Vascular Grafts Based on Supramolecular Materials

Frontiers in Materials, 2020
Synthetic vascular grafts to be applied as access grafts for hemodialysis often require anti-kinking properties. Previously, electrospun microporous vascular implants based on synthetic supramolecular materials have been shown to perform adequately as ...
Dan Jing Wu, Dan Jing Wu, Dan Jing Wu, Kim van Dongen, Kim van Dongen, Kim van Dongen, Wojciech Szymczyk, Wojciech Szymczyk, Paul J. Besseling, Ruth M. Cardinaels, Giulia Marchioli, Giulia Marchioli, Giulia Marchioli, Marcel H. P. van Genderen, Marcel H. P. van Genderen, Carlijn V. C. Bouten, Carlijn V. C. Bouten, Anthal I. P. M. Smits, Anthal I. P. M. Smits, Patricia Y. W. Dankers, Patricia Y. W. Dankers, Patricia Y. W. Dankers   +21 more
doaj   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Polarize the Solvent to Regulate the Intermediate Phase and Dynamic Crystallization of Perovskite Films

Advanced Materials, EarlyView.
A solvent engineering strategy using polar polymers is introduced to regulate perovskite crystallization dynamics in solar cells. Strongly polarized fluorinated groups stabilize the intermediate phase and control solvent exfoliation, leading to high‐quality films with suppressed defects.
Zhuoqiong Zhang, Yunfan Wang, Weizhen Wang, Yulan Huang, Shanchao Ouyang, Yonggui Sun, Fei Wang, Xianfang Zhou, Guichuan Xing, Shu Kong So, Guozhong Xing, Hanlin Hu, Songhua Cai, Sai‐Wing Tsang, Tom Wu   +14 more
wiley   +1 more source

物理学 [PDF]

, 1988
application ...
林 光彦, 田村 一郎, 豊富 誠三
core   +22 more sources

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source

Mechanochemical Treatment of Cellulose: A Strategy for Developing Functional Biocomposite Materials

Polymer Engineering &Science, Volume 66, Issue 2, Page 662-688, February 2026.
Mechanochemistry as an integrated approach for combining fiber defibrillation, activation, surface functionalization, and cellulose‐based composite fabrication in a single or reduced number of steps. ABSTRACT Cellulose‐based biocomposites are attracting increasing scientific and industrial interest due to their sustainable origin, biodegradability, and
Murilo O. da Luz, Otávio Bianchi, Sandro Campos Amico, Fernanda T. G. Dias   +3 more
wiley   +1 more source

Synthesis of Some Thienopyrimidine Derivatives

Molecules, 2006
Thioxothienopyrimidinones, alkylthio- and arylalkylthiothienopyrimidinones, thienopyrimidinones, thienopyrimidines a thienopyrimidinedione and a thienotriazolo- pyrimidinone were prepared from 2-amino-3-carboethoxy-4,5-disubstituted thiophenes and 2 ...
Hassan M. Al-Hazimi, Hanan A. S. Al-Blowy, Fatma E. M. El-Baih   +2 more
doaj   +1 more source