Results 61 to 70 of about 7,405 (269)

Synthesis of thiophene and N-substituted thieno[3,2-d] pyrimidine derivatives as potent antitumor and antibacterial agents

Acta Pharmaceutica, 2017
A novel series of carbamothioylamino-benzene-sulfonamide-thiophene-carboxylates 4a-c and thieno[3,2-d]pyrimidin-2-yl-amino-benzene-sulfonamides 5a-c were synthesized in a series of synthetic steps and were used as key intermediates for the synthesis of ...
Hafez Hend N., Alsalamah Sulaiman A., El-Gazzar Abdel-Rhman B. A.   +2 more
doaj   +1 more source

Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity

BMC Cancer, 2017
Background Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an attractive drug target in cancer ...
C. P. Baburajeev, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Daniel J. Mason, Julian E. Fuchs, Andreas Bender, Uri Barash, Israel Vlodavsky, Basappa, Kanchugarakoppal S. Rangappa   +9 more
doaj   +1 more source

Synthesis and biological evaluation of novel fused triazolo[4,3-$a$] pyrimidinones

, 2015
The reaction of thione 3 or its 2-methylthio derivative 4 with hydrazonoyl halides 5a{l, in the presence of triethylamine, yielded the corresponding triazolo(4,3-a)pyrimidin-5(1H)-ones 8a{l.
I. M. Abbas, Sobhi M. Gomha, M. A. Elneairy, M. Elaasser, Bazada K. A. Mabrouk   +4 more
semanticscholar   +1 more source

One-Pot Eco-Safe Saccharin-Catalyzed Procedure for Expedient and Convenient Synthesis of Dihydropyrano[2,3-c]pyrazole, Tetrahydrobenzo[b]pyran and Pyrano[2,3-d]pyrimidinone Scaffolds as a Green and Versatile Catalyst

Indonesian Journal of Chemistry, 2018
A green and facile saccharin-catalyzed procedure is developed for the one-pot convenient synthesis of dihydropyrano[2,3-c]pyrazole, tetrahydrobenzo[b]pyran and pyrano[2,3-d]pyrimidinone scaffolds via multi-component tandem Knoevenagel cyclocondensation ...
Farzaneh Mohamadpour, Mojtaba Lashkari, Nourallah Hazeri   +2 more
doaj   +1 more source

Synthesis and Applications of Fluorinated Multi-Carbonyl Systems via Batch and Flow Processes [PDF]

, 2018
Organofluorine chemistry has played a significant role in the majority of the spectacular scientific and technological developments of the past century.
LISSE, ETIENNE
core  

One-Pot Multicomponent Synthesis of Novel 2-Thioxo-Benzo[6,7]Chromeno[2,3d]Pyrimidin-4-one Derivatives using Cetylpyridinium Chloride [PDF]

, 2014
The novel 2-thioxo-benzo[5,6]chromeno[2,3-d]pyrimidin-4-one derivatives were prepared by one pot multicomponent condensation reaction involving thiobarbituric acids, aromatic aldehydes and β-napthol in acetonitrile-water as solvent using surfactant ...
Ahanthem, Dini, Laitonjam, Warjeet S.
core   +1 more source

The role of phosphotungstic acid in enhancing the catalytic performance of UiO-66 (Zr) and its applications as an efficient solid acid catalyst for coumarins and dihydropyrimidinones synthesis

Catalysis Communications, 2022
In recent study, we report a facile and easy technique for the synthesis phosphotungstic acid (PTA) with different weight contents (10, 25, 50 and 75 wt%) loaded on UiO-66 (Zr) as efficient and reusable catalysts for the preparation of coumarin and ...
Fares T. Alshorifi, Dina E. Tobbala, Salah M. El-Bahy, Mohamed A. Nassan, Reda S. Salama   +4 more
doaj  

Discovering The New Heterocycles of Therapeutic Interest [PDF]

, 2004
Not ...
Acharya, Hitarth H.
core  

Regio- and stereoselective synthesis of benzothiazolo-pyrimidinones via an NHC-catalyzed Mannich/lactamization domino reaction

Chemical Communications, 2014
An NHC-catalyzed regio- and stereoselective Mannich/lactamization domino reaction of N-(benzothiazolyl)imines with α-chloroaldehydes has been developed.
Qijian Ni, Xiaoxiao Song, Jiawen Xiong, G. Raabe, D. Enders   +4 more
semanticscholar   +1 more source

Pentafluorophenylammonium triflate (PFPAT) catalyzed facile construction of substituted chromeno[2,3-d]pyrimidinone derivatives and their antimicrobial activity

Journal of Advanced Research, 2014
A new, simple thermally efficient and solvent-free condensation of 2-amino-3-cyano-6-methyl-4-phenyl-4H-pyran-5-ethylcarboxylate derivatives with coumarin-3-carboxylic acid employing pentafluorophenylammonium triflate (PFPAT) as an inexpensive ...
Majid Ghashang, Syed Sheik Mansoor, Krishnamoorthy Aswin   +2 more
doaj   +1 more source