Results 61 to 70 of about 4,994 (242)

Aza-Michael mono-addition using acidic alumina under solventless conditions [PDF]

, 2016
Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the ...
Abdilla, Roderick, Bosica, Giovanna
core   +2 more sources

Design, Synthesis, In Silico Absorption, Distribution, Metabolism, and Elimination and Molecular Docking Studies of Thiazole‐Based Furan Derivatives, and Their Biological Evaluation for Alzheimer Disease Therapy

ChemistryOpen, Volume 14, Issue 12, December 2025.
GA: Oxidative stress plays a critical role in Alzheimer's disease (AD) by promoting Aβ plaque accumulation and tau pathology, accelerating neurodegeneration. Elevated reactive oxygen species contribute to cognitive decline through extensive oxidative damage.
Abdüllatif Karakaya, Ulviye Acar Çevik, Betül Kaya, Bilge Çiftçi, Adem Necip, Mesut Işık, Şükrü Beydemir, Yusuf Özkay, Zafer Asım Kaplancıklı   +8 more
wiley   +1 more source

1,3‐Diazetidin‐2‐Ones: Synthetic Approaches and Therapeutic Promise within the Aza‐β‐Lactam Family

European Journal of Organic Chemistry, Volume 28, Issue 43, November 24, 2025.
This review explores the synthesis, reactivity, and therapeutic potential of 1,3‐diazetidin‐2‐ones—an underexplored class of aza‐β‐lactams. Emphasis is placed on synthetic challenges, emerging methodologies, and their promise as β‐lactamase‐resistant scaffolds in medicinal chemistry. 1,3‐diazetidin‐2‐ones, overlooked members of the aza‐β‐lactam family,
Jozef Kristek, Jiří Pospíšil
wiley   +1 more source

A novel VIVO–pyrimidinone complex: synthesis, solution speciation and human serum protein binding [PDF]

, 2013
The pyrimidinones mhcpe, 2-methyl-3H-5-hydroxy-6-carboxy-4-pyrimidinone ethyl ester (mhcpe, 1), 2,3- dimethyl-5-benzyloxy-6-carboxy-4-pyrimidinone ethyl ester (dbcpe, 2) and N-methyl-2,3-dimethyl-5- hydroxy-6-carboxyamido-4-pyrimidinone (N-MeHOPY, 3 ...
Avecilla, Fernando, Castro, M. M. C. A., Correia, Isabel, Garcia, M. Helena V., Gonçalves, Gisela, Jakusch, Támas, Kiss, Támas, Maestro, Miguel, Palacio, Lorena, Pessoa, João Costa, Tomaz, Isabel, Vieiros, Luís F.   +11 more
core   +1 more source

Synthesis of thiophene and N-substituted thieno[3,2-d] pyrimidine derivatives as potent antitumor and antibacterial agents

Acta Pharmaceutica, 2017
A novel series of carbamothioylamino-benzene-sulfonamide-thiophene-carboxylates 4a-c and thieno[3,2-d]pyrimidin-2-yl-amino-benzene-sulfonamides 5a-c were synthesized in a series of synthetic steps and were used as key intermediates for the synthesis of ...
Hafez Hend N., Alsalamah Sulaiman A., El-Gazzar Abdel-Rhman B. A.   +2 more
doaj   +1 more source

Docking and Molecular Dynamics Simulation‐Based Analysis of Advanced Small‐Molecule Kinase Inhibitors Identified pre‐let‐7 miRNA Binders

ChemBioChem, Volume 26, Issue 22, November 17, 2025.
An integrated computational approach evaluating the binding between pre‐let‐7 microRNA and small‐molecule kinase inhibitors (SMKIs) revealed varied pre‐let‐7 binding affinities among the advanced SMKIs. The results justified the characterization of potential RNA targets for kinase inhibitors and small molecules with protein targets in general.
Soma Roy, Yang Liu, Peng Wu
wiley   +1 more source

Sigmatropic rearrangements in 5-allyloxytetrazoles [PDF]

, 2011
Mechanisms of thermal isomerization of allyl tetrazolyl ethers derived from the carbocyclic allylic alcohols cyclohex-2-enol and 3-methylcyclohex-2-enol and from the natural terpene alcohol nerol were investigated.
Abell, Abramovitch, Amin Ismael, Araújo, Araújo, Barkley, Basch, Becke, Bugalho, Bugalho, Cristiano, Cristiano, Cristiano, Cristiano, Daniela V. Coelho, Desarro, Dąbkowska, Frija, Frija, Frija, Frija, Frija, Frija, Frisch, Gu, Gómez-Zavaglia, Hashimoto, Head-Gordon, Igor Reva, Johnstone, Koldobskii, Lee, Luís M. T. Frija, M. Lurdes S. Cristiano, Mavromoustakos, McCarthy, Mishra, Pacios, Peng, Peng, Rui Fausto, Sandmann, Tamura, Toney   +43 more
core   +1 more source

Using a Supramolecular Approach to Engineer Modular Hydrogel Platforms for Culturing Protoplasts – from General Tissue Engineering to Cellular Agriculture

Advanced Biology, Volume 9, Issue 11, November 2025.
Using supramolecular monomers, various hydrogel culture systems were formulated to culture protoplasts; including 2D, 2.5D, and 3D hydrogels. Depending on the culture platform, bioactive functionalization led to protoplast enlargement (2D and 2.5D) or plasmolysis (3D). This work shows the potential to modularly engineer synthetic platforms for cellular
Maritza M. Rovers, Erik J. Slootweg, Ferdinand C. O. Los, Patricia Y. W. Dankers   +3 more
wiley   +1 more source

Expression of a malarial Hsp70 improves defects in chaperone-dependent activities in ssa1 mutant yeast [PDF]

, 2011
Plasmodium falciparum causes the most virulent form of malaria and encodes a large number of molecular chaperones. Because the parasite encounters radically different environments during its lifecycle, many members of this chaperone ensemble may be ...
A Adams, A Shonhai, A Shonhai, AG Maier, AJ McClellan, AL Goldberg, AN Chiang, Annette N. Chiang, B Bukau, BJ Foth, BK Baxter, BM Greenwood, CG Evans, CH Leng, CJ Stirling, CJ Tonkin, CM Wright, CR Brown, D Ang, D Mumberg, D Sharma, DA Fidock, DE Stone, EA Craig, EC Schirmer, ER Pesce, FU Hartl, G Banumathy, G Misra, HA Hundley, J Becker, J Jungmann, J Nylandsted, JD Thompson, Jeffrey L. Brodsky, JL Brodsky, JL Brodsky, K Hill, K Nadeau, K Nakatsukasa, K Normington, L Shaner, LE Cowen, M Agarwal, M Botha, M Botha, M Kabani, M Werner-Washburne, Michael Polymenis, MJ Gardner, MP Mayer, ND Karunaweera, NH Hunt, OO Odunuga, P Walsh, RH Schiestl, RJ Deshaies, RJ Nelson, RS Sikorski, S Rudiger, S Toovey, Samantha L. Bell, SG Nadler, SR Pavithra, SW Fewell, T Munder, TN Ramya, TN Ramya, TS Matambo, WJ Chirico, Y Midorikawa, Y Tutar, Y Zhang, YD Sharma, YR Lee   +74 more
core   +5 more sources

Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity

BMC Cancer, 2017
Background Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an attractive drug target in cancer ...
C. P. Baburajeev, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Daniel J. Mason, Julian E. Fuchs, Andreas Bender, Uri Barash, Israel Vlodavsky, Basappa, Kanchugarakoppal S. Rangappa   +9 more
doaj   +1 more source