Syntheses and reactions of [1,3,4]thiadiazolo[3,2‐a]pyrimidinone derivatives [PDF]
Tadakazu Tsuji
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3,6-Dimethyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one 3 was prepared by an intramolecular cyclization of N-(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl) acetamide 2 in ethanol in the presence of piperidine.
Ameur Rahmouni+5 more
doaj
Design, Synthesis, In Vitro, and In Silico Studies of New N5-Substituted-pyrazolo[3,4-d]pyrimidinone Derivatives as Anticancer CDK2 Inhibitors [PDF]
Waheed A. Zaki+10 more
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Caesium carbonate promoted regioselective O-functionalization of 4,6-diphenylpyrimidin-2(1H)-ones under mild conditions and mechanistic insight. [PDF]
Kumar V+7 more
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Photochemical Ring-Opening Reaction in 2(1H)-Pyrimidinones: A Matrix Isolation Study [PDF]
Leszek Lapiński+4 more
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Синтез і біологічне визначення тієнопіримідинонів як інгібіторів протеїнкінази СК2 [PDF]
З метою пошуку нових інгібіторів протеїнкінази СК2 синтезовано і проведено in vitro тести 86 похідних тієно[2,3-d]піримідинону. Серед них виявлено 15 активних сполук із IC50 від 2,5 до 20 мкМ.
Баланда, А.О.+6 more
core
Potent Inhibition of HhaI DNA Methylase by the Aglycon of 2‐(1H)‐Pyrimidinone Riboside (Zebularine) at the GCGC Recognition Domain [PDF]
Víctor E. Márquez+4 more
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Asymmetric Carbon—Carbon Bond Formations in Conjugate Additions of Lithiated N‐Boc Allylic and Benzylic Amines to Nitroalkenes: Enantioselective Synthesis of Substituted Piperidines, Pyrrolidines, and Pyrimidinones. [PDF]
Timothy A. Johnson+4 more
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Recently, heterocyclic compounds such as pyrido [2,3-d] pyrimidinones, 1,2,4-triazolopyrimidines, pyrimidoquinazolines, and quinoline derivatives have gained attention from researchers due to their pharmacological and biological activities. To synthesize
Ameen Ali Abu-Hashem+2 more
doaj