Results 31 to 40 of about 2,744 (177)

Supercritical fluid extraction of γ-Pyrones from Ammi visnaga L. fruits

open access: yesFuture Journal of Pharmaceutical Sciences, 2018
Extraction with supercritical fluid technique has proved to be effective in many applications including extraction and separation of various active principals from medicinal plants.
Mokhtar Bishr   +4 more
doaj   +1 more source

Selected α-pyrones from the plants Cryptocarya novoguineensis (Lauraceae) and Piper methysticum (Piperaceae) with activity against Haemonchus contortus in vitro

open access: yesInternational Journal for Parasitology: Drugs and Drug Resistance, 2019
Due to the widespread occurrence and spread of anthelmintic resistance, there is a need to develop new drugs against resistant parasitic nematodes of livestock animals.
H.M.P. Dilrukshi Herath   +12 more
doaj   +1 more source

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

open access: yesAgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John   +4 more
wiley   +1 more source

Bioactivity-Guided Screening of Antimicrobial Secondary Metabolites from Antarctic Cultivable Fungus Acrostalagmus luteoalbus CH-6 Combined with Molecular Networking

open access: yesMarine Drugs, 2022
With the increasingly serious antimicrobial resistance, discovering novel antibiotics has grown impendency. The Antarctic abundant microbial resources, especially fungi, can produce unique bioactive compounds for adapting to the hostile environment.
Ting Shi   +6 more
doaj   +1 more source

Free Phenolic Hydroxyl Groups Govern the Anticancer Activity of α‐Mangostin: A Structure–Activity Relationship Insight

open access: yesChemFoodChem, EarlyView.
Free phenolic hydroxyl groups in the chemical structure of the natural xanthone α‐mangostin (MGT) contribute positively to achieving the anticancer profile against murine colon cancer, murine triple negative breast cancer, and human osteosarcoma cancer. ABSTRACT The α‐mangostin (MGT) is a natural xanthone obtained from the pericarp of mangosteen fruit (
Otávio Augusto Chaves   +7 more
wiley   +1 more source

Recent Advances in the Synthesis of 2-Pyrones

open access: yesMarine Drugs, 2015
The present review summarizes the recent progresses in the synthesis of 2-pyrones and the application to the synthesis of marine natural products. Especially, much attention was placed on the transition metal catalyzed synthetic methodologies in this ...
Jong Seok Lee
doaj   +1 more source

Senotherapeutics for Knee Osteoarthritis

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman   +6 more
wiley   +1 more source

Caffeylpyruvate hydrolase from the bioluminescent fungus Neonothopanus gardneri is the key recycling enzyme in the fungal bioluminescence pathway

open access: yesThe FEBS Journal, EarlyView.
Caffeic acid is a central metabolite in the fungal bioluminescence pathway. We identified and characterized caffeylpyruvate hydrolase from Neonothopanus gardneri (ngarCPH) and demonstrate its ability to hydrolyze fungal oxyluciferin into caffeic and pyruvic acids, confirming a complete and self‐sustained fungal bioluminescence cycle.
Caio K. Zamuner   +8 more
wiley   +1 more source

Isotelluroureas for Asymmetric C1 Ammonium Enolate Reactions

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 31, 19 August 2026.
Chiral isotelluroureas are powerful catalysts for a variety of C─C bond forming C1 ammonium enolate transformations. Isotelluroureas (ITeUs) have recently been introduced as a novel class of highly nucleophilic Lewis base catalysts. Herein, we systematically screened them for their potential to facilitate C1 ammonium enolate transformations and ...
Fereshteh Khorasani   +3 more
wiley   +1 more source

Reimagining Lignin Valorization: Synthetic Biology–Enabled Sustainable Aromatic Carbon Biomanufacturing

open access: yesAdvanced Science, Volume 13, Issue 47, 24 August 2026.
The diagram illustrates a sustainable model of lignin valorization and carbon cycling based on microbial cell factories. Using lignin as the feedstock, synthetic biology technologies, including depolymerization, cell factory construction, pathway gene module integration, and metabolic network regulation, are applied to convert lignin into bulk ...
Na Li   +4 more
wiley   +1 more source

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