Metal Acetylides in Cycloaddition Reactions [PDF]
, 2017 This review highlights recent advances in the synthesis of (hetero)aromatic systems via cycloaddition reactions of alkynylmetals with dienes and dipoles.
Comas-Barceló, J., Harrity, J.P.A.
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Novel, male-produced aggregation pheromone of the cerambycid beetle Rosalia alpina, a priority species of European conservation concern. [PDF]
, 2017 Several recent studies have demonstrated the great potential for exploiting semiochemicals in ecology and conservation studies. The cerambycid beetle Rosalia alpina represents one of the flagship species of saproxylic insect biodiversity in Europe.
Hoskovec, Michal +5 more
core +3 more sources
Convergent Total Synthesis of 16β‐Hydroxylpseudobufarenogin
Angewandte Chemie, EarlyView.We present a novel convergent strategy that integrates Pd/Ag‐promoted Suzuki–Miyaura coupling with Ir‐catalyzed radical‐relay cyclization, enabling the first total synthesis of 16β‐hydroxylpseudobufarenogin. This approach is broadly applicable to the total synthesis of various oxygenated bufadienolides by simply modifying the fragment structures ...
Wataru Shigematsu +3 more
wiley +2 more sources
Indenopyrans – synthesis and photoluminescence properties
Beilstein Journal of Organic Chemistry, 2016 New indeno[1,2-c]pyran-3-ones bearing different substituents at the pyran moiety were synthesized and their photophysical properties were investigated. In solution all compounds were found to be blue emitters and the trans isomers exhibited significantly
Andreea Petronela Diac +6 more
doaj +1 more source
Divergent rhodium-catalyzed electrochemical vinylic C–H annulation of acrylamides with alkynes
Nature Communications, 2021 α-Pyridones and α-pyrones are ubiquitous structural motifs found in natural products and components of biologically active small molecules. Here, the authors report an oxidant-free Rh-catalyzed electrochemical divergent vinylic C–H annulation of ...
Yi-Kang Xing +6 more
doaj +1 more source
Modulation of neural cell membrane conductance by the herbal anxiolytic and antiepileptic drug aswal [PDF]
, 2000 To evaluate the effects of aswal on ionic fluxes and neuronal excitation, we performed extracellular and whole cell patch clamp recordings on CA1 pyramidal neurons of guinea pigs and Long-Evans rats.
Grunze, Heinz +3 more
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Biosynthesis of Amino Acid Derived α-Pyrones by an NRPS-NRPKS Hybrid Megasynthetase in Fungi.
Journal of Natural Products, 2020 A nonribosomal peptide synthetase (NRPS)-nonreducing polyketide synthase (NRPKS) hybrid enzyme (AnATPKS) from Aspergillus niger was shown to produce amino acid derived α-pyrone natural products (pyrophen and campyrone B).
Y. Hai, Arthur Huang, Yi Tang
semanticscholar +1 more source
CRISPR-Cas9-Based Discovery of the Verrucosidin Biosynthesis Gene Cluster in Penicillium polonicum
Frontiers in Microbiology, 2021 Penicillium polonicum, commonly found on food matrices, is a mycotoxigenic species able to produce a neurotoxin called verrucosidin. This methylated α-pyrone polyketide inhibits oxidative phosphorylation in mitochondria and thereby causes neurological ...
Silvia Valente +11 more
doaj +1 more source
A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity in vivo [PDF]
, 2016 Loss of appetite in the medically ill and ageing populations is a major health problem and a significant symptom in cachexia syndromes, which is the loss of muscle and fat mass. Ghrelin is a gut-derived hormone which can stimulate appetite.
Clarke, Sarah L. +7 more
core +3 more sources
Sulfur analogs of fluorinated pyrones, chromones and coumarins [PDF]
, 2012 This mini-review describes the synthesis and reactions of sulfur analogs of partially fluorinated pyrones, chromones, coumarins and isocoumarins and their utility as building blocks for the synthesis of trifluoromethyl-containing heterocyclic compounds ...
Sosnovskikh, V. Ya.
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