Results 1 to 10 of about 70,546 (390)
Nano-Scale Manipulation of Single-Molecule Conformational Transition Through Vibrational Excitation [PDF]
arXivOn-demand control of molecular actions is essential for realizing single-molecule functional devices. Such a control can be achieved by manipulating interactions between individual molecules and their nanoscale environment. In this study, we manipulate the conformational transition of a single pyrrolidine molecule on a Cu(100) surface by exciting its ...
Quan W +8 more
arxiv +2 more sources
Glycine-Based [3+2] Cycloaddition for the Synthesis of Pyrrolidine-Containing Polycyclic Compounds [PDF]
MoleculesThe synthesis of pyrrolidine compounds with biological interest is an active research topic. Glycine could be a versatile starting material for making pyrrolidine derivatives.
Tieli Zhou +3 more
doaj +2 more sources
Pyrrolidine nucleotide analogs with a tunable conformation [PDF]
Beilstein Journal of Organic Chemistry, 2014 Conformational preferences of the pyrrolidine ring in nucleotide analogs 7–14 were investigated by means of NMR and molecular modeling. The effect of the relative configuration of hydroxy and nucleobase substituents as well as the effect of the ...
Lenka Poštová Slavětínská +2 more
doaj +4 more sources
Nylon 4,I: an amorphous polyamide [PDF]
, 1984 The melt polymerization of nylon 4, I was studied, starting with nylon-salt and nylon prepolymers (ηinh=0.25). With nylon-salt only low molecular polymers were obtained, while with prepolymers the inherent viscosity could be raised to 0.77 (3h, 270°, vac.
Gaymans, R.J., Ham, A.G.J. van der
core +16 more sources
Recent insights about pyrrolidine core skeletons in pharmacology
Frontiers in Pharmacology, 2023 To overcome numerous health disorders, heterocyclic structures of synthetic or natural origin are utilized, and notably, the emergence of various side effects of existing drugs used for treatment or the resistance of disease-causing microorganisms ...
S. Poyraz +4 more
semanticscholar +1 more source
Therapeutic potential of pyrrole and pyrrolidine analogs: an update
Molecular diversity, 2022 The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has been a versatile field of study for a long time for its diverse biological and medicinal importance .
N. Jeelan Basha +2 more
semanticscholar +1 more source
Pyrrolidine in Drug Discovery: A Versatile Scaffold for Novel Biologically Active Compounds
Topics in current chemistry, 2021 The five-membered pyrrolidine ring is one of the nitrogen heterocycles used widely by medicinal chemists to obtain compounds for the treatment of human diseases.
Giovanna Li Petri +5 more
semanticscholar +1 more source
Symmetry, 2021 A series of new spiro-heterocycles engrafted spirooxindole/pyrrolidine/thiochromene scaffolds was synthesized by the three-component 1,3-dipolar cycloaddition reactions in a fully controlled regio- and stereo-selective fashion.
A. Barakat +7 more
semanticscholar +1 more source
Acta Crystallographica Section E Structure Reports Online, 2012 In the title compound, C(4)H(5)NO(2), the non-H atoms are nearly coplanar, with a maximum deviation of 0.030 (1) Å. In the crystal, pairs of mol-ecules are linked by N-H⋯O hydrogen bonds into inversion dimers.
Xing Huang, Min Yu, Feng Gao
openaire +3 more sources
Asymmetric Synthesis of Polyfunctionalized Pyrrolidines from Sulfinimine-Derived Pyrrolidine 2-Phosphonates. Synthesis of Pyrrolidine 225C [PDF]
Organic Letters, 2006 [reaction: see text] The Horner-Wadsworth-Emmons reaction of aldehydes with sulfinimine-derived 3-oxo pyrrolidine phosphonates represents a new method for the asymmetric synthesis of ring-functionalized cis-2,5-disubstituted 3-oxo pyrrolidines.
He Xu +3 more
openaire +3 more sources