Results 31 to 40 of about 81,237 (352)

Stereochemical diversity in pyrrolidine synthesis by catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides.

Chemical Communications, 2019
The pyrrolidine ring is a privileged structural motif in synthetic and medicinal chemisty. This review aims to highlight the high versatility of the catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides for access to different types of ...
J. Adrio, J. Carretero
semanticscholar   +1 more source

Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents

Molecules, 2018
(Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically active molecules. Metal-catalyzed cross-couplings between halogeno N-heterocycles and organometallic species are efficient and modular reactions to access these ...
Baptiste Barré, Laurine Gonnard, Amandine Guérinot, Janine Cossy   +3 more
doaj   +1 more source

1-Ethyl 2-methyl 3,4-bis(acetyloxy)pyrrolidine-1,2-dicarboxylate: crystal structure, Hirshfeld surface analysis and computational chemistry

Acta Crystallographica Section E: Crystallographic Communications, 2020
The title compound, C13H19NO8, is based on a tetra-substituted pyrrolidine ring, which has a twisted conformation about the central C—C bond; the Cm—Ca—Ca—Cme torsion angle is 38.26 (15)° [m = methylcarboxylate, a = acetyloxy and me = methylene].
Sofia Dallasta Pedroso, Ignez Caracelli, Julio Zukerman-Schpector, Monica Soto-Monsalve, Regina H. De Almeida Santos, Carlos Roque D. Correia, Ariel L. Llanes Garcia, Huey Chong Kwong, Edward R. T. Tiekink   +8 more
doaj   +1 more source

Green synthesis of highly functionalized octahydropyrrolo[3,4-c]pyrrole derivatives using subcritical water, and their anti(myco)bacterial and antifungal activity [PDF]

, 2018
A series of novel 2-(thiazol-2-yl)-octahydropyrrolo[3,4-c]pyrroles was synthesized by reaction of octahydropyrrolo[3,4-c]pyrrole N-benzoylthiourea derivatives and α-haloketones in subcritical water at 130 °C in 75-91% yield.
De Coen, Laurens, Gemili, Muge, Nural, Yahya, Ulger, Mahmut, Yabalak, Erdal   +4 more
core   +1 more source

Enantioselective synthesis of tricyclic amino acid derivatives based on a rigid 4-azatricyclo[5.2.1.02,6]decane skeleton

Beilstein Journal of Organic Chemistry, 2009
An enantioselective route to four tricyclic amino acids and N-tosylamides, composed of a central norbornane framework with a 2-endo,3-endo-annelated pyrrolidine ring and a 5-endo-C1 or -C2 side chain, has been developed. A key intermediate was the chiral,
Matthias Breuning, Tobias Häuser, Christian Mehler, Christian Däschlein, Carsten Strohmann, Andreas Oechsner, Holger Braunschweig   +6 more
doaj   +1 more source

Evaluation of the Bioactivity of Novel Spiroisoxazoline TypeCompounds against Normal and Cancer Cell Lines

Molecules, 2010
The aim of this study was to investigate the in vitro cellular activity of novel spiroisoxazoline type compounds against normal and cancer cell lines from lung tissue (Hs888Lu), neuron-phenotypic cells (SH-SY5Y), neuroblastoma (SH-SY5Y), human ...
Nigar Najim, Yaser Bathich, Mazatulikhma Mat Zain, Ahmad Sazali Hamzah, Zurina Shaameri   +4 more
doaj   +1 more source

One-Pot Synthesis, X-ray Single Crystal and Molecular Insight of Enaminone-Based β-Morpholino-/N-Methylpiperazinyl-/Pyrrolidinylpropiophenone

Crystals, 2020
One-pot synthesis of three enaminones, (E)-1-(4-chlorophenyl)-3-morpholinoprop-2-en-1-one 1, (E)-1-(4-chlorophenyl)-3-(4-methylpiperazin-1-yl)prop-2-en-1-one 2, and (E)-1-(4-chlorophenyl)-3-(pyrrolidin-1-yl)prop-2-en-1-one 3 were achieved.
Assem Barakat, Saied M. Soliman, Matti Haukka, Abdullah Mohammed Al-Majid, Mohammad Shahidul Islam, M. Ali, Mohammed Rafi Shaik   +6 more
doaj   +1 more source

1-(Pyrrolidin-1-yl)ethan-1-iminium chloride

IUCrData, 2023
The title compound, C6H13N2+·Cl−, is as an amidinium salt that was isolated as unexpected product from the reaction between acetonitrile, chloroform and pyrrolidine under refluxing conditions.
Rylan Artis, Clifford W. Padgett, Brandon Quillian   +2 more
doaj   +1 more source

Novel sulfur and selenium containing bis-α-amino acids from 4-hydroxyproline [PDF]

, 2010
The synthesis of new substituted prolines carrying at C-4 a second α-amino acid residue is reported. The amino acid, l-cysteine or l-selenocysteine, is linked to the proline ring through the sulfur or the selenium atom, respectively.
CAPUTO, ROMUALDO, D. MASTROIANNI, DELLA GRECA, MARINA, I. de PAOLA, LONGOBARDO, LUIGI   +4 more
core   +1 more source

Tetraethyl(pyrrolidine-2,2-diyl)bisphosphonate [PDF]

Molecules, 2001
The synthesis of the title compound is already described [1, 2] and we report here the fully optimized procedure.[...]
Olive, Gilles, Jacques, Alain
openaire   +3 more sources