Results 31 to 40 of about 70,546 (390)
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 The treatment of neuropathic pain is one of the urgent unmet medical needs and T-type calcium channels are promising therapeutic targets for neuropathic pain.
Hak Kyun Yang +9 more
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Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title compound, C23H22N2O4S, the pyrrolidine ring has an envelope conformation with the spiro C atom, shared with the indoline ring system, as the flap. The mean planes of the benzothiophene and indoline ring systems are inclined to the mean plane
M. P. Savithri +4 more
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Acta Crystallographica Section E: Crystallographic Communications, 2018 In the title dispiro compound, C32H26ClN3O2, the cyclohexanone ring of the isoquinoline unit has a distorted envelope conformation, with the methylene C atom adjacent to the spiro C atom as the flap.
R. Vishnupriya +5 more
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Diastereodivergent synthesis of chiral tetrahydropyrrolodiazepinediones via a one-pot intramolecular aza-Michael/lactamization sequence [PDF]
, 2018 A modular and diastereodivergent synthesis of tetrahydro-1H-pyrrolo[1,2d]diazepine-(2,5)-diones is presented. The tetrahydropyrrolodiazepinedione scaffold is obtained via a base-mediated three-step isomerization/tandem cyclization of amino acid-coupled ...
Brown, Lauren E. +3 more
core +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title compound, C30H23N3O4, the central 1-methylpyrrolidine ring adopts a twist conformation on the N—CH2 bond. The pyrrolidin-2-one ring of the indolin-2-one ring system also has a twist conformation on the C—C bond involving the spiro C atom and
Sadasivam Mathusalini +4 more
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Drug Repurposing for COVID-19 via Knowledge Graph Completion [PDF]
, 2020 Objective: To discover candidate drugs to repurpose for COVID-19 using literature-derived knowledge and knowledge graph completion methods. Methods: We propose a novel, integrative, and neural network-based literature-based discovery (LBD) approach to identify drug candidates from both PubMed and COVID-19-focused research literature.
arxiv +1 more source
Ethyl 1-benzyl-1,2,3,3a,4,10b-hexa-hydro-pyrrolo-[2',3':3,4]pyrrolo-[1,2-a]benzimidazole-2-carboxyl-ate. [PDF]
, 2011 The title mol-ecule, C(22)H(23)N(3)O(2), was obtained via an intra-molecular cyclo-addition of an azomethine ylide and an alkene tethered by a benzimidazole unit. The benzoimidazole unit is essentially planar, with an r.m.s.
Fettinger, James C +2 more
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Stereoselective Synthesis of Cyclobutanes by Contraction of Pyrrolidines [PDF]
Journal of the American Chemical Society, 2021 Here we report a contractive synthesis of multisubstituted cyclobutanes containing multiple stereocenters from readily accessible pyrrolidines using iodonitrene chemistry. Mediated by a nitrogen extrusion process, the stereospecific synthesis of cyclobutanes involves a radical pathway.
Chunngai Hui +5 more
openaire +4 more sources
A Photocatalytic Method for the Degradation of Pyrrolidine in Water [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2000 A method for the degradation of pyrrolidine in water is described. The method relaies on the photocatalytic degradation of pyrrolidine to CO2 and NH3 by UV irradiation and using titanium dixide semiconductor as a photocatalyst.
Mohammad Hossein Habibi +1 more
doaj
Regioselective ring opening of aziridine for synthesizing azaheterocycle
Frontiers in Chemistry, 2023 Aziridine had different regioselective ring openings depending on the functional group of its alkyl substituent. In the case of the alkyl group bearing γ-ketone at the C2 substituent of aziridine, the ring opening by the hydroxy nucleophile from H2O ...
Nikhil Srivastava, Hyun-Joon Ha
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