Pyruvate carboxylase and cancer progression [PDF]
Cancer & Metabolism, 2021 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle.
Violet A. Kiesel +7 more
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CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase [PDF]
Nature Communications, 2022 Pyruvate Carboxylase is a multifunctional enzyme that follows a multi-pathway reaction. Here, the authors, using cryoEM and classification techniques, reveal several catalytic states at reaction sites, the interplay between them, and their relationship ...
Jorge Pedro López-Alonso +5 more
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Elevated Brain Glutamate Levels in Bipolar Disorder and Pyruvate Carboxylase-Mediated Anaplerosis [PDF]
Frontiers in Psychiatry, 2021 In vivo1H magnetic resonance spectroscopy studies have found elevated brain glutamate or glutamate + glutamine levels in bipolar disorder with surprisingly high reproducibility.
Jun Shen, Jyoti Singh Tomar
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Journal of Biological Chemistry, 1966 Abstract Pyruvate carboxylase contains firmly bound manganese which affects the longitudinal relaxation rate of the protons of water as measured by pulsed nuclear magnetic resonance. The manganese shows an enhanced effect (ϵb = 4.2) on the relaxation rate when bound to the enzyme.
Albert S. Mildvan +2 more
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A Unique Case of Pyruvate Carboxylase Deficiency. [PDF]
Cureus, 2021 Pyruvate carboxylase (PC) converts pyruvate to oxaloacetate, which is an important step in gluconeogenesis. Pyruvate carboxylase deficiency (PCD) is a rare inherited metabolic disorder characterized by movement disorders, neurologic disturbances, hypoglycemia, lactic acidosis, hyperammonemia, and elevated levels of pyruvate and alanine in plasma.
Hidalgo J +4 more
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Clinical, biochemical, and molecular profiles of three Sri Lankan neonates with pyruvate carboxylase deficiency [PDF]
Advances in Laboratory MedicinePyruvate carboxylase, a mitochondrial enzyme, catalyses the conversion of glycolytic end-product pyruvate to tricarboxylic acid cycle intermediate, oxaloacetate. Rare pyruvate carboxylase deficiency manifests in three clinical and biochemical phenotypes:
Jasinge Eresha +12 more
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The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase [PDF]
Nature Communications, 2022 Adipocyte-expressed long non-coding RNAs (lncRNAs) have been shown to regulate the transcription of genes involved in lipid metabolism. Here the authors describe a human adipocyte-specific lncRNA, ADIPINT, which regulates lipid metabolism in white ...
Alastair G. Kerr +12 more
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Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis [PDF]
BMC Cancer, 2021 Background Pyruvate carboxylase (PC) is an important anaplerotic enzyme in the tricarboxylic acid cycle (TCA) in cancer cells. Although PC overexpression has been observed in thyroid cancer (TC), the mechanisms involved in the carcinogenic effects of PC ...
Chang Liu +4 more
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PC Splice-Site Variant c.1825+5G>A Caused Intron Retention in a Patient With Pyruvate Carboxylase Deficiency: A Case Report [PDF]
Frontiers in Pediatrics, 2022 BackgroundPyruvate carboxylase deficiency (PCD; MIM#266150) is a rare autosomal recessive disorder characterized by a wide range of clinical features, including delayed neurodevelopment, elevated pyruvate levels, lactic acidosis, elevated ketone levels ...
DongYing Tao +6 more
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Pyruvate Carboxylase and Phosphoenolpyruvate Carboxykinase Activity in Leukocytes and Fibroblasts from a Patient with Pyruvate Carboxylase Deficiency [PDF]
Pediatric Research, 1979 Normal values are given for the activities of pyruvate carboxylase (E.C.6.4.1.1), mitochondrial phosphoenolpyruvate carboxykinase (E.C. 4.1.1.32, PEPCK), and citrate synthase (E.C. 4.1.3.7) in fibroblasts, lymphocytes, and leukocytes. Also given are values for these enzymes in the leukocytes and fibroblasts from a severely mentally and developmentally ...
Beth M Atkin +2 more
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