The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase [PDF]
Nature Communications, 2022 Adipocyte-expressed long non-coding RNAs (lncRNAs) have been shown to regulate the transcription of genes involved in lipid metabolism. Here the authors describe a human adipocyte-specific lncRNA, ADIPINT, which regulates lipid metabolism in white ...
Alastair G. Kerr +12 more
doaj +5 more sources
Pyruvate carboxylase and cancer progression [PDF]
Cancer & Metabolism, 2021 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle.
Violet A. Kiesel +7 more
doaj +6 more sources
The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells [PDF]
Nature Communications, 2016 Mice lacking the tumour suppressor p53 are partially protected from developing diabetes. Here the authors show that p53 is upregulated in the pancreas of diabetic mice where it impairs β cell function by repressing expression of mitochondrial pyruvate ...
Xiaomu Li, Jin-Kui Yang, Baile Wang
exaly +4 more sources
CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase [PDF]
Nature Communications, 2022 Pyruvate Carboxylase is a multifunctional enzyme that follows a multi-pathway reaction. Here, the authors, using cryoEM and classification techniques, reveal several catalytic states at reaction sites, the interplay between them, and their relationship ...
Jorge Pedro López-Alonso +5 more
doaj +3 more sources
Elevated Brain Glutamate Levels in Bipolar Disorder and Pyruvate Carboxylase-Mediated Anaplerosis [PDF]
Frontiers in Psychiatry, 2021 In vivo1H magnetic resonance spectroscopy studies have found elevated brain glutamate or glutamate + glutamine levels in bipolar disorder with surprisingly high reproducibility.
Jun Shen, Jyoti Singh Tomar
doaj +3 more sources
Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment [PDF]
Nature Metabolism, 2021 The aberrant production of collagen by fibroblasts is a hallmark of many solid tumours and can influence cancer progression. How the mesenchymal cells in the tumour microenvironment maintain their production of extracellular matrix proteins as the ...
Simon Schwörer +2 more
exaly +3 more sources
Allosteric regulation alters carrier domain translocation in pyruvate carboxylase [PDF]
Nature Communications, 2018 Carrier domain enzymes accomplish catalysis by physically transporting intermediates long distances between remote active sites. Here the authors describe a wide range of catalytically productive translocation events during catalysis by pyruvate ...
Yumeng Liu +3 more
doaj +5 more sources
Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis [PDF]
BMC Cancer, 2021 Background Pyruvate carboxylase (PC) is an important anaplerotic enzyme in the tricarboxylic acid cycle (TCA) in cancer cells. Although PC overexpression has been observed in thyroid cancer (TC), the mechanisms involved in the carcinogenic effects of PC ...
Chang Liu +4 more
doaj +3 more sources
mBio, 2022 In Bacillus subtilis and other Gram-positive bacteria, cyclic di-AMP is an essential second messenger that signals potassium availability by binding to a variety of proteins.
Larissa Krüger +8 more
doaj +2 more sources
Pyruvate carboxylase deficiency [PDF]
Ryōikibetsu shōkōgun shirīzu, 2020 Researchers have identified at least three types of pyruvate carboxylase deficiency, which are distinguished by the severity of their signs and symptoms.
William L. Nyhan +3 more
semanticscholar +5 more sources