Pyruvate carboxylase and cancer progression. [PDF]
Cancer Metab, 2021 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle.
Kiesel VA +7 more
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Elevated Brain Glutamate Levels in Bipolar Disorder and Pyruvate Carboxylase-Mediated Anaplerosis. [PDF]
Front Psychiatry, 2021 In vivo1H magnetic resonance spectroscopy studies have found elevated brain glutamate or glutamate + glutamine levels in bipolar disorder with surprisingly high reproducibility.
Shen J, Tomar JS.
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Allosteric regulation alters carrier domain translocation in pyruvate carboxylase [PDF]
Nature Communications, 2018 Carrier domain enzymes accomplish catalysis by physically transporting intermediates long distances between remote active sites. Here the authors describe a wide range of catalytically productive translocation events during catalysis by pyruvate ...
Yumeng Liu +3 more
doaj +4 more sources
CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. [PDF]
Nat Commun, 2022 Pyruvate Carboxylase is a multifunctional enzyme that follows a multi-pathway reaction. Here, the authors, using cryoEM and classification techniques, reveal several catalytic states at reaction sites, the interplay between them, and their relationship ...
López-Alonso JP +6 more
europepmc +2 more sources
Sustained Control of Pyruvate Carboxylase by the Essential Second Messenger Cyclic di-AMP in Bacillus subtilis. [PDF]
mBio, 2021 In Bacillus subtilis and other Gram-positive bacteria, cyclic di-AMP is an essential second messenger that signals potassium availability by binding to a variety of proteins.
Krüger L +8 more
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The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase. [PDF]
Nat Commun, 2022 Adipocyte-expressed long non-coding RNAs (lncRNAs) have been shown to regulate the transcription of genes involved in lipid metabolism. Here the authors describe a human adipocyte-specific lncRNA, ADIPINT, which regulates lipid metabolism in white ...
Kerr AG +12 more
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Clinical, biochemical, and molecular profiles of three Sri Lankan neonates with pyruvate carboxylase deficiency [PDF]
Adv Lab MedPyruvate carboxylase, a mitochondrial enzyme, catalyses the conversion of glycolytic end-product pyruvate to tricarboxylic acid cycle intermediate, oxaloacetate. Rare pyruvate carboxylase deficiency manifests in three clinical and biochemical phenotypes:
Jasinge E +12 more
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A Unique Case of Pyruvate Carboxylase Deficiency. [PDF]
Cureus, 2021 Pyruvate carboxylase (PC) converts pyruvate to oxaloacetate, which is an important step in gluconeogenesis. Pyruvate carboxylase deficiency (PCD) is a rare inherited metabolic disorder characterized by movement disorders, neurologic disturbances, hypoglycemia, lactic acidosis, hyperammonemia, and elevated levels of pyruvate and alanine in plasma.
Hidalgo J +4 more
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PC Splice-Site Variant c.1825+5G>A Caused Intron Retention in a Patient With Pyruvate Carboxylase Deficiency: A Case Report. [PDF]
Front Pediatr, 2022 BackgroundPyruvate carboxylase deficiency (PCD; MIM#266150) is a rare autosomal recessive disorder characterized by a wide range of clinical features, including delayed neurodevelopment, elevated pyruvate levels, lactic acidosis, elevated ketone levels ...
Tao D +6 more
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Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis. [PDF]
BMC Cancer, 2021 Background Pyruvate carboxylase (PC) is an important anaplerotic enzyme in the tricarboxylic acid cycle (TCA) in cancer cells. Although PC overexpression has been observed in thyroid cancer (TC), the mechanisms involved in the carcinogenic effects of PC ...
Liu C, Zhou X, Pan Y, Liu Y, Zhang Y.
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