Results 11 to 20 of about 23,834 (239)

Melanoma-derived versican reactivates tumor-associated macrophages by upregulating pyruvate carboxylase through TLR2-MyD88-RelB axis under normoxia [PDF]

Acta Biochimica et Biophysica Sinica
Relieving hypoxia in the tumor microenvironment (TME) promotes innate and adaptive immunity. Our previous research demonstrated that reoxygenation of the TME promotes the phagocytosis and tumor-killing functions of tumor-associated macrophages (TAMs) by ...
Shu Yuxin, Zhou Linmin, Qian Jinqin, Zhu Wei-Guo   +3 more
doaj   +2 more sources

Pyruvate Carboxylase as a Moonlighting Metabolic Enzyme Protects β‐Cell From Senescence [PDF]

Journal of Diabetes
Yumei Yang, Baomin Wang, Xiaomu Li
doaj   +2 more sources

Properties and Function of Yeast Pyruvate Carboxylase

Journal of Biological Chemistry, 1965
M Ruíz-Amil, Gertrudis de Torrontegui, Enrique Palacián, L. Catalina, Matilde Otero‐Losada   +4 more
openalex   +5 more sources

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

Advanced Science
Atherosclerosis (AS) is a major cause of cardiovascular diseases, driven by chronic inflammation and macrophage polarization toward a proinflammatory phenotype.
Ling‐Na Zhao, Rui‐Ling Wang, Ran‐Xin Liu, Meng‐Ru Zheng, Li Zhao, Bao‐Feng Li, Jia‐Le Li, De‐Shen Liu, Xiao‐Xia He, Qin‐Bao Peng, Kai Li, Tian‐Xiao Lin, Ying‐Ying Liu, Sheng‐Ping He, Jun Lu, Shao‐Yi Zheng, Xiu Liu, Fang‐Ze Huang   +17 more
doaj   +2 more sources

Distribution of pyruvate carboxylase and phosphoenol‐pyruvate carboxikinase in human liver [PDF]

FEBS Letters, 1968
O. Wieland, E. Evertz-Prüsse, Barbara Stukowski   +2 more
openalex   +4 more sources

Author Correction: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase [PDF]

Nature Communications, 2022
Jorge Pedro López-Alonso, Melisa Lázaro, David Gil-Cartón, Philip H. Choi, Alexandra Dodu, Liang Tong, Mikel Valle   +6 more
doaj   +2 more sources

A case of pyruvate carboxylase deficiency with longer survival and normal laboratory findings.

Acta Medica Iranica, 2021
Pyruvate carboxylase deficiency (PCD) is a rare autosomal recessive defect in a biotin-containing enzyme, Pyruvate carboxylase, which is considered as an enzyme of TCA-cycle regulation, gluconeogenesis, lipogenesis, and biosynthesis of neurotransmitters.
shahin koohmanaee, nejat mahdie, Reza Bayat, fatemeh kharaee, Maryam Shahrokhi, Afagh Hassanzadeh Rad, Saber Najafi Chakoosari, setila dalili   +7 more
doaj   +1 more source

Exogenous trehalose differently improves photosynthetic carbon assimilation capacities in maize and wheat under heat stress

Journal of Plant Interactions, 2022
High temperature inhibits the growth and development of maize (Zea mays L.) and wheat (Triticum aestivum L.) seedlings. The current study attempts to elucidate the underlying mechanisms of exogenous trehalose for the improvement of maize and wheat ...
Ziwei Zhang, Mei Sun, Yamin Gao, Yin Luo
doaj   +1 more source

Sustained Control of Pyruvate Carboxylase by the Essential Second Messenger Cyclic di-AMP in Bacillus subtilis

mBio, 2022
In Bacillus subtilis and other Gram-positive bacteria, cyclic di-AMP is an essential second messenger that signals potassium availability by binding to a variety of proteins.
Larissa Krüger, Christina Herzberg, Dennis Wicke, Patricia Scholz, Kerstin Schmitt, Asan Turdiev, Vincent T. Lee, Till Ischebeck, Jörg Stülke   +8 more
doaj   +1 more source

Metabolic engineering of CHO cells for the development of a robust protein production platform. [PDF]

PLoS ONE, 2017
Chinese hamster ovary (CHO) cells are the most preferred mammalian host used for the bio-pharmaceutical production. A major challenge in metabolic engineering is to balance the flux of the tuned heterogonous metabolic pathway and achieve efficient ...
Sanjeev Kumar Gupta, Santosh K Srivastava, Ankit Sharma, Vaibhav H H Nalage, Darshita Salvi, Hiralal Kushwaha, Nikhil B Chitnis, Pratyoosh Shukla   +7 more
doaj   +1 more source