Results 11 to 20 of about 1,570 (117)

Manganese orchestrates a metabolic shift leading to the increased bioconversion of glycerol into α-ketoglutarate.

AIMS Bioengineering, 2016
Glycerol is a major by-product of the biodiesel industry and its transformation into value-added products is an ongoing technological challenge. Here we report on the ability of the nutritionally-versatile Pseudomonas fluorescens to synthesize copious ...
Azhar A. Alhasawi, Vasu D. Appanna
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Comprehensive Analysis of C. glutamicum Anaplerotic Deletion Mutants Under Defined d-Glucose Conditions

Frontiers in Bioengineering and Biotechnology, 2021
Wild-type C. glutamicum ATCC 13032 is known to possess two enzymes with anaplerotic (C4-directed) carboxylation activity, namely phosphoenolpyruvate carboxylase (PEPCx) and pyruvate carboxylase (PCx). On the other hand, C3-directed decarboxylation can be
Jannick Kappelmann, Bianca Klein, Mathias Papenfuß, Julian Lange, Bastian Blombach, Ralf Takors, Wolfgang Wiechert, Tino Polen, Stephan Noack   +8 more
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The Central Role of Glucokinase in Glucose Homeostasis: A Perspective 50 Years After Demonstrating the Presence of the Enzyme in Islets of Langerhans

Frontiers in Physiology, 2019
It is hypothesized that glucokinase (GCK) is the glucose sensor not only for regulation of insulin release by pancreatic β-cells, but also for the rest of the cells that contribute to glucose homeostasis in mammals. This includes other cells in endocrine
Franz M. Matschinsky, David F. Wilson
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Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis

BMC Cancer, 2021
Background Pyruvate carboxylase (PC) is an important anaplerotic enzyme in the tricarboxylic acid cycle (TCA) in cancer cells. Although PC overexpression has been observed in thyroid cancer (TC), the mechanisms involved in the carcinogenic effects of PC ...
Chang Liu, Xiang Zhou, Yu Pan, Yang Liu, Yifan Zhang   +4 more
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The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells

Cells, 2021
Pyruvate occupies a central metabolic node by virtue of its position at the crossroads of glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed by numerous cell-intrinsic and extrinsic factors.
Edward V. Prochownik, Huabo Wang
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Metabolic engineering of fast-growing Vibrio natriegens for efficient pyruvate production

Microbial Cell Factories, 2023
Background Pyruvate is a widely used value-added chemical which also serves as a hub of various metabolic pathways. The fastest-growing bacterium Vibrio natriegens is a promising chassis for synthetic biology applications with high substrate uptake rates.
Fengli Wu, Shucai Wang, Yanfeng Peng, Yufeng Guo, Qinhong Wang   +4 more
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A distinct holoenzyme organization for two-subunit pyruvate carboxylase

Nature Communications, 2016
Pyruvate carboxylases are homotetrameric enzymes in eukaryotes and most bacteria. Here, the authors report the structure of an unusual two-subunit form of the enzyme from the Gram-negative bacterium Methylobacillus flagellates, revealing an unexpected ...
Philip H. Choi, Jeanyoung Jo, Yu-Cheng Lin, Min-Han Lin, Chi-Yuan Chou, Lars E. P. Dietrich, Liang Tong   +6 more
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Pyruvate carboxylase deficiency: An underestimated cause of lactic acidosis

Molecular Genetics and Metabolism Reports, 2015
Pyruvate carboxylase (PC) is a biotin-containing mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, thereby being involved in gluconeogenesis and in energy production through replenishment of the tricarboxylic acid (TCA ...
F. Habarou, A. Brassier, M. Rio, D. Chrétien, S. Monnot, V. Barbier, R. Barouki, J.P. Bonnefont, N. Boddaert, B. Chadefaux-Vekemans, L. Le Moyec, J. Bastin, C. Ottolenghi, P. de Lonlay   +13 more
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Geniposide regulates glucose-stimulated insulin secretion possibly through controlling glucose metabolism in INS-1 cells. [PDF]

PLoS ONE, 2013
Glucose-stimulated insulin secretion (GSIS) is essential to the control of metabolic fuel homeostasis. The impairment of GSIS is a key element of β-cell failure and one of causes of type 2 diabetes mellitus (T2DM).
Jianhui Liu, Lixia Guo, Fei Yin, Yonglan Zhang, Zixuan Liu, Yanwen Wang   +5 more
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Clinical, biochemical, and molecular profiles of three Sri Lankan neonates with pyruvate carboxylase deficiency

Advances in Laboratory Medicine
Pyruvate carboxylase, a mitochondrial enzyme, catalyses the conversion of glycolytic end-product pyruvate to tricarboxylic acid cycle intermediate, oxaloacetate. Rare pyruvate carboxylase deficiency manifests in three clinical and biochemical phenotypes:
Jasinge Eresha, Fernando Mihika, Indika Neluwa-Liyanage Ruwan, Ratnayake Pyara Dilani, Gamaathige Nalin, Ratnaranjith Ratnanathan, Schroeder Sabine, Jones Patricia, Volha Skrahina, Jayasena Subhashinie, Gunaratna Anusha Varuni, Bandara Ekanayake Asitha Niroshana, Rolfs Arndt   +12 more
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