Results 21 to 30 of about 141,799 (322)

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

Cell Reports, 2016
Cellular proliferation depends on refilling the tricarboxylic acid (TCA) cycle to support biomass production (anaplerosis). The two major anaplerotic pathways in cells are pyruvate conversion to oxaloacetate via pyruvate carboxylase (PC) and glutamine ...
Stefan Christen, Doriane Lorendeau, Roberta Schmieder, Dorien Broekaert, Kristine Metzger, Koen Veys, Ilaria Elia, Joerg Martin Buescher, Martin Franz Orth, Shawn Michael Davidson, Thomas Georg Philipp Grünewald, Katrien De Bock, Sarah-Maria Fendt   +12 more
doaj   +2 more sources

Pyruvate Carboxylase as a Moonlighting Metabolic Enzyme Protects β‐Cell From Senescence [PDF]

Journal of Diabetes
Yumei Yang, Baomin Wang, Xiaomu Li
doaj   +2 more sources

Pyruvate carboxylase deficiency [PDF]

Ryōikibetsu shōkōgun shirīzu, 2020
Researchers have identified at least three types of pyruvate carboxylase deficiency, which are distinguished by the severity of their signs and symptoms.
William L. Nyhan, Georg F. Hoffmann, Aida I. Al-Aqeel, Bruce A. Barshop   +3 more
semanticscholar   +5 more sources

Retracted: LINC00092 Modulates Oxidative Stress and Glycolysis of Breast Cancer Cells via Pyruvate Carboxylase-Mediated AKT/mTOR Pathway. [PDF]

Oxid Med Cell Longev, 2023
Longevity OMAC.
europepmc   +3 more sources

Genome‐Wide CRISPR/Cas9 Library Screening Revealed Dietary Restriction of Glutamine in Combination with Inhibition of Pyruvate Metabolism as Effective Liver Cancer Treatment

Advanced Science, 2022
Hepatocellular carcinoma (HCC) is the second most lethal cancer worldwide. Glutamine is an essential, extracellular nutrient which supports HCC growth. Dietary glutamine deficiency may be a potential therapeutic approach for HCC.
Chunxue Yang, Derek Lee, Misty Shuo Zhang, Aki Pui‐Wah Tse, Lai Wei, Macus Hao‐Ran Bao, Bowie Po‐Yee Wong, Cerise Yuen‐Ki Chan, Vincent Wai‐Hin Yuen, Yiling Chen, Carmen Chak‐Lui Wong   +10 more
doaj   +2 more sources

Author Correction: CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase [PDF]

Nature Communications, 2022
Jorge Pedro López-Alonso, Melisa Lázaro, David Gil-Cartón, Philip H. Choi, Alexandra Dodu, Liang Tong, Mikel Valle   +6 more
doaj   +2 more sources

A case of pyruvate carboxylase deficiency with longer survival and normal laboratory findings.

Acta Medica Iranica, 2021
Pyruvate carboxylase deficiency (PCD) is a rare autosomal recessive defect in a biotin-containing enzyme, Pyruvate carboxylase, which is considered as an enzyme of TCA-cycle regulation, gluconeogenesis, lipogenesis, and biosynthesis of neurotransmitters.
shahin koohmanaee, nejat mahdie, Reza Bayat, fatemeh kharaee, Maryam Shahrokhi, Afagh Hassanzadeh Rad, Saber Najafi Chakoosari, setila dalili   +7 more
doaj   +1 more source

Rethinking the Citric Acid Cycle: Connecting Pyruvate Carboxylase and Citrate Synthase to the Flow of Energy and Material

International Journal of Molecular Sciences, 2021
In 1937, Sir H. A Krebs first published the Citric Acid Cycle, a unidirectional cycle with carboxylic acids. The original concept of the Citric Acid Cycle from Krebs’ 1953 Nobel Prize lecture illustrates the unidirectional degradation of lactic acid to ...
D. Roosterman, G. Cottrell
semanticscholar   +1 more source

Exogenous trehalose differently improves photosynthetic carbon assimilation capacities in maize and wheat under heat stress

Journal of Plant Interactions, 2022
High temperature inhibits the growth and development of maize (Zea mays L.) and wheat (Triticum aestivum L.) seedlings. The current study attempts to elucidate the underlying mechanisms of exogenous trehalose for the improvement of maize and wheat ...
Ziwei Zhang, Mei Sun, Yamin Gao, Yin Luo
doaj   +1 more source

Conformational Selection Governs Carrier Domain Positioning in Staphylococcus aureus Pyruvate Carboxylase. [PDF]

Biochemistry, 2022
Hakala JH, Laseke AJ, Koza AL, St Maurice M.   +3 more
europepmc   +3 more sources