Results 21 to 30 of about 1,570 (117)
Allosteric regulation alters carrier domain translocation in pyruvate carboxylase
Nature Communications, 2018 Carrier domain enzymes accomplish catalysis by physically transporting intermediates long distances between remote active sites. Here the authors describe a wide range of catalytically productive translocation events during catalysis by pyruvate ...
Yumeng Liu +3 more
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Nonstructural 5A protein of hepatitis C virus interacts with pyruvate carboxylase and modulates viral propagation. [PDF]
PLoS ONE, 2013 Hepatitis C virus (HCV) is highly dependent on cellular factors for its own propagation. By employing tandem affinity purification method, we identified pyruvate carboxylase (PC) as a cellular partner for NS5A protein. NS5A interacted with PC through the
Seung-Ae Yim +3 more
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Nature Communications, 2016 Mice lacking the tumour suppressor p53 are partially protected from developing diabetes. Here the authors show that p53 is upregulated in the pancreas of diabetic mice where it impairs β cell function by repressing expression of mitochondrial pyruvate ...
Xiaomu Li +12 more
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Biotechnology for Biofuels and Bioproducts, 2023 Background Fuels and chemicals derived from non-fossil sources are needed to lessen human impacts on the environment while providing a healthy and growing economy.
Ziyu Dai +14 more
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Frontiers in Pediatrics, 2022 BackgroundPyruvate carboxylase deficiency (PCD; MIM#266150) is a rare autosomal recessive disorder characterized by a wide range of clinical features, including delayed neurodevelopment, elevated pyruvate levels, lactic acidosis, elevated ketone levels ...
DongYing Tao +6 more
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IET Systems Biology, 2023 Insulin, a key hormone in the regulation of glucose homoeostasis, is secreted by pancreatic β‐cells in response to elevated glucose levels. Insulin is released in a biphasic manner in response to glucose metabolism in β‐cells.
Rahul Rahul +3 more
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Impaired G2/M cell cycle arrest induces apoptosis in pyruvate carboxylase knockdown MDA-MB-231 cells
Biochemistry and Biophysics Reports, 2021 Background: Previous studies showed that suppression of pyruvate carboxylase (PC) expression in highly invasive breast cancer cell line, MDA-MB-231 inhibits cell growth as a consequence of the impaired cellular biosynthesis. However, the precise cellular
Khanti Rattanapornsompong +6 more
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Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression
Breast Cancer ResearchBackground Metabolic plasticity mediates breast cancer survival, growth, and immune evasion during metastasis. However, how tumor cell metabolism is influenced by and feeds back to regulate breast cancer progression are not fully understood.
Michael F. Coleman +17 more
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The citrate cleavage pathway and lipogenesis in rat adipose tissue: replenishment of oxaloacetate
Journal of Lipid Research, 1967 Fatty acid synthesis via the citrate cleavage pathway requires the continual replenishment of oxaloacetate within the mitochondria, probably by carboxylation of pyruvate.Malic enzyme, although present in adipose tissue, is completely localized in the ...
F.J. Ballard, Richard W. Hanson
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Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer
Breast Cancer Research, 2018 Background Overcoming systemic dormancy and initiating secondary tumor grow under unique microenvironmental conditions is a major rate-limiting step in metastatic progression.
Aparna Shinde +4 more
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