Distribution of pyruvate carboxylase and phosphoenol‐pyruvate carboxikinase in human liver [PDF]
FEBS Letters, 1968 Wieland, O. +2 more
openaire +3 more sources
Metabolic engineering of CHO cells for the development of a robust protein production platform. [PDF]
PLoS ONE, 2017 Chinese hamster ovary (CHO) cells are the most preferred mammalian host used for the bio-pharmaceutical production. A major challenge in metabolic engineering is to balance the flux of the tuned heterogonous metabolic pathway and achieve efficient ...
Sanjeev Kumar Gupta +7 more
doaj +1 more source
Analyzing clonal variation of monoclonal antibody-producing CHO cell lines using an in silico metabolomic platform. [PDF]
PLoS ONE, 2014 Monoclonal antibody producing Chinese hamster ovary (CHO) cells have been shown to undergo metabolic changes when engineered to produce high titers of recombinant proteins.
Atefeh Ghorbaniaghdam +3 more
doaj +1 more source
Assessment of hepatic pyruvate carboxylase activity using hyperpolarized [1‐13C]‐l‐lactate
Magnetic Resonance in Medicine, 2020 To evaluate the utility of hyperpolarized [1‐13C]‐l‐lactate to detect hepatic pyruvate carboxylase activity in vivo under fed and fasted conditions.
Jun Chen +4 more
semanticscholar +1 more source
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source
Impaired G2/M cell cycle arrest induces apoptosis in pyruvate carboxylase knockdown MDA-MB-231 cells
Biochemistry and Biophysics Reports, 2021 Background: Previous studies showed that suppression of pyruvate carboxylase (PC) expression in highly invasive breast cancer cell line, MDA-MB-231 inhibits cell growth as a consequence of the impaired cellular biosynthesis. However, the precise cellular
Khanti Rattanapornsompong +6 more
doaj +1 more source
The citrate cleavage pathway and lipogenesis in rat adipose tissue: replenishment of oxaloacetate
Journal of Lipid Research, 1967 Fatty acid synthesis via the citrate cleavage pathway requires the continual replenishment of oxaloacetate within the mitochondria, probably by carboxylation of pyruvate.Malic enzyme, although present in adipose tissue, is completely localized in the ...
F.J. Ballard, Richard W. Hanson
doaj +1 more source
Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells
Nature Communications, 2023 Deregulated oxidative metabolism is a hallmark of leukaemia. While tyrosine kinase inhibitors (TKIs) such as imatinib have increased survival of chronic myeloid leukaemia (CML) patients, they fail to eradicate disease-initiating leukemic stem cells (LSCs)
Kevin M. Rattigan +18 more
doaj +1 more source
Synthesis and Evaluation of 1,3-Disubstituted Imidazolidine-2,4,5-triones as Inhibitors of Pyruvate Carboxylase. [PDF]
ACS Med Chem LettSchneider NO +5 more
europepmc +3 more sources