Results 31 to 40 of about 23,834 (239)

A distinct holoenzyme organization for two-subunit pyruvate carboxylase

Nature Communications, 2016
Pyruvate carboxylases are homotetrameric enzymes in eukaryotes and most bacteria. Here, the authors report the structure of an unusual two-subunit form of the enzyme from the Gram-negative bacterium Methylobacillus flagellates, revealing an unexpected ...
Philip H. Choi, Jeanyoung Jo, Yu-Cheng Lin, Min-Han Lin, Chi-Yuan Chou, Lars E. P. Dietrich, Liang Tong   +6 more
doaj   +1 more source

Structure, function and regulation of pyruvate carboxylase [PDF]

Biochemical Journal, 1999
Pyruvate carboxylase (PC; EC 6.4.1.1), a member of the biotin-dependent enzyme family, catalyses the ATP-dependent carboxylation of pyruvate to oxaloacetate. PC has been found in a wide variety of prokaryotes and eukaryotes. In mammals, PC plays a crucial role in gluconeogenesis and lipogenesis, in the biosynthesis of neurotransmitter substances, and ...
Jitrapakdee, S., Wallace, J.
openaire   +4 more sources

Geniposide regulates glucose-stimulated insulin secretion possibly through controlling glucose metabolism in INS-1 cells. [PDF]

PLoS ONE, 2013
Glucose-stimulated insulin secretion (GSIS) is essential to the control of metabolic fuel homeostasis. The impairment of GSIS is a key element of β-cell failure and one of causes of type 2 diabetes mellitus (T2DM).
Jianhui Liu, Lixia Guo, Fei Yin, Yonglan Zhang, Zixuan Liu, Yanwen Wang   +5 more
doaj   +1 more source

Structure, mechanism and regulation of pyruvate carboxylase [PDF]

Biochemical Journal, 2008
PC (pyruvate carboxylase) is a biotin-containing enzyme that catalyses the HCO3−- and MgATP-dependent carboxylation of pyruvate to form oxaloacetate. This is a very important anaplerotic reaction, replenishing oxaloacetate withdrawn from the tricarboxylic acid cycle for various pivotal biochemical pathways.
Jitrapakdee, S., Maurice, M., Rayment, I., Cleland, W., Wallace, J., Attwood, P.   +5 more
openaire   +4 more sources

Nonstructural 5A protein of hepatitis C virus interacts with pyruvate carboxylase and modulates viral propagation. [PDF]

PLoS ONE, 2013
Hepatitis C virus (HCV) is highly dependent on cellular factors for its own propagation. By employing tandem affinity purification method, we identified pyruvate carboxylase (PC) as a cellular partner for NS5A protein. NS5A interacted with PC through the
Seung-Ae Yim, Yun-Sook Lim, Jong-Wook Kim, Soon B Hwang   +3 more
doaj   +1 more source

My favorite pyruvate carboxylase [PDF]

IUBMB Life, 2010
Having completed a PhD in molecular and cellular biology in mammalian reproduction at the University of Sydney, my first postdoctoral appointment began early in 1965 in the laboratory of Sir Hans Krebs at Oxford University where I had the pleasure of working with Dr Eric Newsholme on the regulation of gluconeogenesis and glycolysis during fetal ...
openaire   +3 more sources

Genomic and Cis‐Regulatory Basis of a Plastic C3‐C4 Photosynthesis in Eleocharis Baldwinii

Advanced Science, EarlyView.
The sedge Eleocharis baldwinii remarkably switches between C3‐like and C4‐like photosynthesis in response to environmental conditions. Combining gap‐free genome assembly with single‐cell multi‐omics, this study uncovers how subgenome dominance and cell‐specific cis‐regulation enable C4 photosynthesis.
Lu Chen, Yanfeng Jia, Zaihui Zhou, Qiying Jiang, Jianlin Liu, Jianhui Gu, Chuan Chen, Shujing Cheng, Jinfang Chu, Xin Liu, Yongjun Lin, Xiang Li   +11 more
wiley   +1 more source

Allosteric regulation alters carrier domain translocation in pyruvate carboxylase

Nature Communications, 2018
Carrier domain enzymes accomplish catalysis by physically transporting intermediates long distances between remote active sites. Here the authors describe a wide range of catalytically productive translocation events during catalysis by pyruvate ...
Yumeng Liu, Melissa M. Budelier, Katelyn Stine, Martin St. Maurice   +3 more
doaj   +1 more source

Metabolic engineering to improve production of 3-hydroxypropionic acid from corn-stover hydrolysate in Aspergillus species

Biotechnology for Biofuels and Bioproducts, 2023
Background Fuels and chemicals derived from non-fossil sources are needed to lessen human impacts on the environment while providing a healthy and growing economy.
Ziyu Dai, Kyle R. Pomraning, Shuang Deng, Joonhoon Kim, Kristen B. Campbell, Ana L. Robles, Beth A. Hofstad, Nathalie Munoz, Yuqian Gao, Teresa Lemmon, Marie S. Swita, Jeremy D. Zucker, Young-Mo Kim, Kristin E. Burnum-Johnson, Jon K. Magnuson   +14 more
doaj   +1 more source

Unraveling Tissue‐Specific Fatty Acid Biosynthesis and Inter‐Tissue Crosstalk in Mice through Stable‐Isotope Tracing Metabolomics

Advanced Science, EarlyView.
Biosynthesis rates of 13 FFAs are quantitatively calculated in 15 tissues from glucose and an analytical framework to quantitatively calculate inter‐tissue communications of fatty acids between the liver and other tissues is developed. Moreover, the approach is extended to aging condition and a system‐wide decline of fatty acid synthesis in peripheral ...
Beizi Xing, Ruohong Wang, Tianzhang Kou, Wenbin Liu, Zheng‐Jiang Zhu   +4 more
wiley   +1 more source