Results 111 to 120 of about 181,145 (327)

The CreC regulator of Escherichia coli, a new target for metabolic manipulations [PDF]

, 2015
The CreBC (carbon source-responsive) two-component regulation system of Escherichia coli affects a number of functions, including intermediary carbon catabolism.
Cabrera Gomez, José Gregorio, Godoy, Manuel Santiago, Nikel, Pablo Ivan, Pettinari, María Julia   +3 more
core   +1 more source

5′tRF‐GlyGCC Promotes Breast Cancer Progression via LDHA‐Mediated Glycolysis and Macrophage Polarization

Advanced Science, EarlyView.
5’tRF‐GlyGCC promotes breast cancer malignancy by binding to LDHA. This interaction, facilitated by FGFR1 and LDHA phosphorylation, enhances glycolysis. Additionally, 5’tRF‐GlyGCC/LDHA signaling recruits and polarizes macrophages into a pro‐tumor M2 state via CCL7, thus remodeling the tumor microenvironment.
Cheng Yi, Yunqing Lu, Xing Chang, Ying Wang, Jiawang Zhou, Guoyou Xie, Lijun Tao, Zhaotong Wang, Yifan Tian, Lihong Wang, Feng Tang, Yijing Zheng, Xinchen Yue, Jinping Lei, Xiansong Wang, Lichen Ge, Zhuojia Chen, Hongsheng Wang   +17 more
wiley   +1 more source

Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis

Neoplasia: An International Journal for Oncology Research, 2019
Even with increasing evidence for roles of glycolytic enzymes in controlling cancerous characteristics, the best target of candidate metabolic enzymes for lessening malignancy remains under debate.
Tsai-Ying Chen, Yi-Ta Hsieh, Jian-Min Huang, Chung-Ji Liu, Lu-Te Chuang, Pei-Chun Huang, Tz-Yu Kuo, Hao-Yuan Chia, Chia-Yi Chou, Ching-Wen Chang, Yi-Fen Chen, Hsin-Ming Chen, Jeng-Fan Lo, Wan-Chun Li   +13 more
doaj   +1 more source

Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer [PDF]

, 2019
York University ...
Bhattacharya, Debasmita, Scimè, Anthony
core   +1 more source

Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors.

Journal of Medicinal Chemistry, 2017
Pyruvate dehydrogenase kinases (PDKs) are overexpressed in most cancer cells and are responsible for aberrant glucose metabolism. We previously described bis(4-morpholinyl thiocarbonyl)-disulfide (JX06, 16) as the first covalent inhibitor of PDK1.
Yifu Liu, Zuoquan Xie, Dan Zhao, Jin Zhu, Fei Mao, Shuai Tang, Hui Xu, C. Luo, M. Geng, Min Huang, Jian Li   +10 more
semanticscholar   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Pyruvate Dehydrogenase Kinase as a Novel Therapeutic Target in Oncology

Frontiers in Oncology, 2013
Current drug development in oncology is non-selective as it typically focuses on pathways essential for the survival of all dividing cells. The unique metabolic profile of cancer, which is characterized by increased glycolysis and suppressed ...
Gopinath eSutendra, Evangelos D. Michelakis   +1 more
doaj   +1 more source

Effects of Low pH on Lactate Dehydrogenase Kinetics of Diving and Nondiving Reptiles [PDF]

, 1986
The properties of lactate dehydrogenase were examined in two snake species, Nerodia rhombifera and Elaphe obsoleta, and a turtle species, Pseudemys scripta.
Baeyens, Dennis A., Hurley, Salim R.
core   +2 more sources

Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells. [PDF]

, 2017
Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has been found to have anti-cancer effects in a variety of malignancies including high grade serous ovarian cancer (HGSC).
Aspuria, Paul-Joseph P, Hodeib, Melissa, Karlan, Beth Y, Lunt, Sophia Y, Ogrodzinski, Martin P, Reue, Karen, Vergnes, Laurent   +6 more
core   +1 more source

RNAi-mediated silencing of a pyruvate dehydrogenase kinase enhances triacylglycerol biosynthesis in the oleaginous marine alga Nannochloropsis salina

Scientific Reports, 2017
Oleaginous microalgae have been emerging as the third-generation feedstocks for biofuel production. Genetic manipulation for improving triacylglycerol (TAG) accumulation represents a promising approach towards the economics of microalgal biofuels. Acetyl-
Xiaonian Ma, Lina Yao, Bo Yang, Yuan-Kun Lee, Feng Chen, Jin Liu   +5 more
semanticscholar   +1 more source