Results 271 to 280 of about 68,490 (304)

Mechanism of pyruvate inhibition of plant pyruvate dehydrogenase kinase and synergism with ADP

Archives of Biochemistry and Biophysics, 1990
The effects of various metabolites on pyruvate dehydrogenase (PDH) kinase-catalyzed inactivation of the pyruvate dehydrogenase complex (PDC) were studied in extracts of mitochondria purified from green leaf tissue of Pisum sativum L. Pyruvate was an uncompetitive inhibitor of PDH kinase with respect to ATP whereas ADP was a competitive inhibitor.
Kathryn A. Schuller, Douglas D. Randall
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Sepsis alters pyruvate dehydrogenase kinase activity in skeletal muscle [PDF]

Molecular and Cellular Biochemistry, 1999
Chronic sepsis promotes a stable increase in pyruvate dehydrogenase kinase (PDHK) activity in skeletal muscle. PDHK is found tightly bound to the pyruvate dehydrogenase (PDH) complex and as free kinase. We investigated the ability of sepsis to modify the activity of the PDHK intrinsic to the PDH and free PDHK.
Thomas C. Vary, Stacy A. Hazen
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AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2

Biochemical Society Transactions, 2003
The PDH (pyruvate dehydrogenase) multi-enzyme complex catalyses a key regulatory step in oxidative glycolysis. Phosphorylation of the E1 subunit of the complex on serine residues results in the inactivation of enzyme activity. A family of four dedicated PDH kinase isoenzymes exists, each of which displays a distinct tissue-specific expression profile ...
Thomas E. Roche, R.J. Butlin, Rachel M. Mayers, E. Kilgour, J.A. Morrell, J.P. Orme   +5 more
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Inhibition of pyruvate dehydrogenase kinase by halogenated acetophenones

Drug Development Research, 1995
AbstractThe activity of pyruvate dehydrogenase (PDH), and hence of glucose oxidation, is regulated by reversible phosphorylation. We have searched for novel PDH‐Kinase inhibitors using a high‐throughput microtiter plate assay. A series of halogenated acetophenones with potent activity against PDH‐Kinase (IC50 1–3 μM) and inactive towards other protein ...
Angela S. Hassman, Mark Beggs, Joseph Espinal, Jeff E. Cobb, Tony Leesnitzer   +4 more
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Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK)

Bioorganic & Medicinal Chemistry Letters, 1999
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Christine C. Vinluan, William R. Mann, Jiaping Gao, Emma L. Kaplan, Judit Koletar, Leonard J. Brand, Robert E. Damon, Thomas Daniel Aicher, Suraj S. Shetty   +8 more
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Additional binding sites for the pyruvate dehydrogenase kinase but not for protein X in the assembled core of the mammalian pyruvate dehydrogenase complex: Binding region for the kinase

Archives of Biochemistry and Biophysics, 1992
A standard resolution of the bovine kidney pyruvate dehydrogenase complex yields a subcomplex composed of approximately 60 dihydrolipoyl transacetylase (E2) subunits, approximately 6 protein X subunits, and approximately 2 pyruvate dehydrogenase kinase heterodimers (KcKb).
Lin Li, Gary A. Radke, Thomas E. Roche, Kazuo Ono   +3 more
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Increased pyruvate dehydrogenase kinase activity in response to sepsis

American Journal of Physiology-Endocrinology and Metabolism, 1991
The effect of sterile inflammation and sepsis on the proportion of active pyruvate dehydrogenase complex (PDH) in mitochondria isolated from skeletal muscle has been investigated. The proportion of active PDH in mitochondria isolated from septic animals was significantly reduced compared with control under all incubation conditions examined, even in ...
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Pyruvate dehydrogenase kinase 2

AfCS-Nature Molecule Pages, 2006
Norbert Tennagels, Mulchand S. Patel, Lioubov G. Korotchkina   +2 more
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Pyruvate metabolism in Haliotis (ormer/abalone): Lactate dehydrogenase, pyruvate kinase and opine dehydrogenase activities

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1987
Abstract 1. 1. Pyruvate kinase is inhibited sigmoidally by ATP in H. cracherodii with a h = −3.9; however, l -Phe inhibits only with a h = −1.2. 2. 2. d -Lactate shows minimal, if any, inhibition of pyruvate kinase and lactate dehydrogenase. 3. 3.
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Pyruvate dehydrogenase kinase 4

AfCS-Nature Molecule Pages, 2006
Norbert Tennagels, Lioubov G. Korotchkina, Mulchand S. Patel   +2 more
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