Results 181 to 190 of about 237,828 (335)

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, EarlyView.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Combined Delivery of CuO Nanoparticles and HIF‐1α Inhibitor Acriflavine for Synergistic Local Treatment of Glioblastoma

Advanced NanoBiomed Research, EarlyView.
Encapsulated acriflavine (ACF) and copper oxide nanoparticles (CuO NPs) are coreleased from coaxial nanofibers, producing synergistic antiglioblastoma multiforme effects. ACF suppresses the hypoxia‐inducible factor 1α pathway related to many downstream factors for tumor growth, while CuO NPs generate reactive oxygen species that assist cuproptosis ...
Daewoo Han, Iris S. Weitz, Hasan Slika, Betty Tyler, Andrew J. Steckl   +4 more
wiley   +1 more source

Role Of Sulfhydryl Groups In The Mechanism Of Action Of Pyruvate Kinase.

, 1971
Michael Flashner
openalex   +1 more source

Spot 14 protein interacts and co-operates with chicken ovalbumin upstream promoter-transcription factor 1 in the transcription of the L-type pyruvate kinase gene through a specificity protein 1 (Sp1) binding site [PDF]

, 2001
Emmanuel Compe, Georges de SOUSA, Kamel FRANÇOIS, Régis Roche, Roger RAHMANI, Janine Torrésani, Michel Raymondjean, Richard Planells   +7 more
openalex   +1 more source

Figure S3 from Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities

, 2023
Andrés Méndez‐Lucas, Xiaolei Li, Junjie Hu, Li Che, Xinhua Song, Jiaoyuan Jia, Jingxiao Wang, Chencheng Xie, Paul C. Driscoll, Darjus F. Tschaharganeh, Diego F. Calvisi, Mariia Yuneva, Xin Chen   +12 more
openalex   +1 more source

Kinetic Characterization and Inhibitor Screening of Pyruvate Kinase I From Babesia microti [PDF]

, 2021
Xiaomeng An, Long Yu, Sen Wang, Yangsiqi Ao, Xueyan Zhan, Qing Liu, Yangnan Zhao, Muxiao Li, Xiang Shu, Fangjie Li, Lan He, Junlong Zhao   +11 more
openalex   +1 more source

Multi‐Omics Insights Into the Role of Fructooligosaccharides Supplementation in Alleviating Salpingitis in Laying Hens

Animal Research and One Health, EarlyView.
Multi‐omics analysis revealed that FOS supplementation increased the abundance of Phascolarctobacterium, GCA‐900066575, Shuttleworthia, Olsenella, Eubacterium_hallii_group while decreasing Alistipes. It also influenced the metabolism of S‐lactoylglutathione, p‐cresol glucuronate, 2‐phenylethanol glucuronide, propionic acid, dulcitol, and inhibited the ...
Dan Song, Tao Duan, Rong Li, Xiaoqiu Wang, Fengdong Zhang, Jia Feng, Lin Qiao, Junlin Cheng, Lixian Chen, Aike Li, Yuna Min, Weiwei Wang   +11 more
wiley   +1 more source

Regulation of pyruvate dehydrogenase kinase activity by protein thiol-disulfide exchange. [PDF]

, 1982
Flora H. Pettit, John Humphreys, Lester J. Reed   +2 more
openalex   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Neonatal Pyruvate Kinase Deficiency Presenting with Severe Hemolytic Anemia and Liver Failure. [PDF]

Children (Basel)
Hsu YH, Jiang CB, Hou JY, Jim WT, Lin SP, Chang SW, Tseng KT, Lee NC.   +7 more
europepmc   +1 more source