Results 41 to 50 of about 237,828 (335)

Role of AMPK Throughout Meiotic Maturation in the Mouse Oocyte: Evidence for Promotion of Polar Body Formation and Suppression of Premature Activation [PDF]

open access: yes, 2010
This study was conducted to assess the role of AMPK in regulating meiosis in mouse oocytes from the germinal vesicle stage to metaphase II. Exposure of mouse cumulus cell-enclosed oocytes (CEO) and denuded oocytes (DO) during spontaneous maturation in ...
Davis, Christopher C.   +2 more
core   +2 more sources

Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production

open access: yesCell Reports, 2019
Summary: Pyruvate kinase is an important enzyme in glycolysis and a key metabolic control point. We recently observed a pyruvate kinase liver isoform (PKL) phosphorylation site at S113 that correlates with insulin resistance in rats on a 3 day high-fat ...
Brandon M. Gassaway   +18 more
doaj   +1 more source

Artificial Photosynthesis Would Unify the Electricity-Carbohydrate-Hydrogen Cycle for Sustainability [PDF]

open access: yes, 2010
Sustainable development requires balanced integration of four basic human needs – air (O2/CO2), water, food, and energy. To solve key challenges, such as CO2 fixation, electricity storage, food production, transportation fuel production, water ...
Yi-Heng Percival Zhang
core   +2 more sources

Pyruvate kinase deficiency mimicking congenital dyserythropoietic anemia type I

open access: yesThe Turkish Journal of Pediatrics, 2022
Background. Pyruvate kinase (PK) deficiency is the most common enzyme abnormality in the glycolytic pathway. Here, we describe two siblings with PK deficiency that mimicked congenital dyserythropoietic anemia (CDA) type I. Case.
Ayça Koca Yozgat   +4 more
doaj   +1 more source

Probing Conformational Feature of a Recombinant Pyruvate Kinase by Limited Proteolysis [PDF]

open access: yesJournal of Sciences, Islamic Republic of Iran, 2013
Pyruvate kinase is a key enzyme in glycolytic pathway that catalyzes the transphosphorylation between phosphoenolpyruvate and ADP to yield ATP and Pyruvate.
M. Banijamali   +2 more
doaj  

Sheng-Mai San extracts attenuate heart injury in chronic intermittent hypoxia via suppressing oxidative damage and regulating glucose metabolism

open access: yesPharmacological Research - Modern Chinese Medicine, 2022
Background: Sheng-Mai San extracts (SMSE), derived from a Chinese medicine formula Sheng-Mai San, benefits prevention and treatment of cardiovascular disease.
Chunhua Liu   +6 more
doaj   +1 more source

LC-MS proteomics analysis of the iInsulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism [PDF]

open access: yes, 2014
The insulin/IGF-1 receptor is a major known determinant of dauer formation, stress resistance, longevity, and metabolism in Caenorhabditis elegans. In the past, whole-genome transcript profiling was used extensively to study differential gene expression ...
Braeckman, Bart   +7 more
core   +2 more sources

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

open access: yesFEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera   +4 more
wiley   +1 more source

Pyruvate kinase deficiency and PKLR gene mutations: Insights from molecular dynamics simulation analysis

open access: yesHeliyon
Pyruvate kinase deficiency is a rare hereditary erythrocyte enzyme disease caused by mutations in the pyruvate kinase liver and red blood cell gene. The clinical presentations of pyruvate kinase deficiency are significantly heterogeneous, ranging from ...
Yang Wang   +13 more
doaj   +1 more source

Molecular heterogeneity of pyruvate kinase deficiency

open access: yesHaematologica, 2020
Red cell pyruvate kinase (PK) deficiency is the most common glycolytic defect associated with congenital non-spherocytic hemolytic anemia. The disease, transmitted as an autosomal recessive trait, is caused by mutations in the PKLR gene and is ...
Paola Bianchi, Elisa Fermo
doaj   +1 more source

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