Results 71 to 80 of about 237,828 (335)

STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]

, 2018
Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F, Carissimi, S, Chichiarelli, S, Eufemi, M, Giamogante, F, Macone, A, Paglia, G, Rubini, E   +7 more
core   +2 more sources

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

A simple and reliable method for determination of optimum pH in coupled enzyme assays

BioTechniques, 2020
Determination of the optimum pH in a coupled enzyme assay poses significant challenges because altering the pH of the reaction mixture can affect the performance of both enzymes.
Lee Bowman, Rachael Motamed, Paul Lee, Kadijah Aleem, Astha S Berawala, Katherine L Hayden, David J Bzik, Debasish Chattopadhyay   +7 more
doaj   +1 more source

Pyruvate Kinase M2 Protects Heart from Pressure Overload‐Induced Heart Failure by Phosphorylating RAC1

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Heart failure, caused by sustained pressure overload, remains a major public health problem. PKM (pyruvate kinase M) acts as a rate‐limiting enzyme of glycolysis. PKM2 (pyruvate kinase M2), an alternative splicing product of PKM, plays complex
Le Ni, Bowen Lin, Lingjie Hu, Ruoyu Zhang, Fengmei Fu, Meiting Shen, Jian Yang, Dan Shi   +7 more
doaj   +1 more source

Pyruvate kinase M2 at a glance [PDF]

Journal of Cell Science, 2015
Reprogrammed metabolism is a key feature of cancer cells. The pyruvate kinase M2 (PKM2) isoform, which is commonly upregulated in many human cancers, has been recently shown to play a crucial role in metabolism reprogramming, gene transcription and cell cycle progression.
Weiwei, Yang, Zhimin, Lu
openaire   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma. [PDF]

PLoS ONE, 2013
Normal tissues express the M1 isoform of pyruvate kinase (PK) that helps generate and funnel pyruvate into the mitochondria for ATP production. Tumors, in contrast, express the less active PKM2 isoform, which limits pyruvate production and spares ...
Joydeep Mukherjee, Joanna J Phillips, Shichun Zheng, John Wiencke, Sabrina M Ronen, Russell O Pieper   +5 more
doaj   +1 more source

The allosteric regulation of pyruvate kinase [PDF]

FEBS Letters, 1996
Crystallographic and mutagenesis studies have unravelled the general features of the allosteric transition mechanism in pyruvate kinase. The enzyme displays a dramatic conformational change in going from the T‐ to the R‐state. All three domains forming each subunit of the tetrameric enzyme undergo simultaneous and concerted rotations, in such a way ...
MATTEVI, ANDREA, VALENTINI, GIOVANNA, BOLOGNESI M.   +2 more
openaire   +3 more sources

CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation [PDF]

, 2003
CD40 is a 48-kDa phosphorylated transmembrane glycoprotein belonging to the TNF receptor superfamily. CD40 has been demonstrated on a range of cell types, and it has an important role in adaptive immunity and inflammation.
Callard, R.E., Inwald, D.P., Klein, N.J., McDowall, A., Peters, M.J.   +4 more
core  

Maximizing efficiency of rumen microbial protein production. [PDF]

, 2015
Rumen microbes produce cellular protein inefficiently partly because they do not direct all ATP toward growth. They direct some ATP toward maintenance functions, as long-recognized, but they also direct ATP toward reserve carbohydrate synthesis and ...
Andries, Argyle, Armstead, Asanuma, Asanuma, Atasoglu, Atasoglu, Atasoglu, Bailey, Bailey, Baldwin, Baldwin, Bas, Bond, Bond, Bond, Buurman, Caldara, Chen, Cheng, Clapperton, Clark, Cook, Costerton, Cotta, Cotta, Counotte, Denton, Diaz, Diez-Gonzalez, Dijkstra, Dijkstra, Dijkstra, Duncan, Dunne, Falony, Ferla, Fields, Firkins, Firkins, Firkins, Firkins, Flint, Forsberg, Gaudet, Gottschalk, Hackmann, Hackmann, Hackmann, Hall, Hanigan, Hindson, Hino, Hobson, Hobson, Hottiger, Hristov, Hristov, Isaacson, Janssen, Jenkins, Jouany, Kajikawa, Kajikawa, Kajikawa, Kalcheva, Karnati, Kim, Koenig, Krause, Kristensen, Larsson, Leedle, Lohkamp, Lou, Lou, Lou, Louis, Mackie, Maia, Martin, Matheron, Matulova, McAllan, Morgan, Morgavi, Morrison, Morrison, Mountfort, Mouriño, Mulder, Nagaraja, Neijssel, Newbold, Newsholme, Newsholme, Nouaille, NRC., Oldick, Or-Rashid, Otto, Paillard, Paulus, Pirt, Piwonka, Portais, Prabhu, Preiss, Prins, Rosewarne, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Russell, Ryan, Saleem, Schönheit, Shi, Shi, Stewart, Storm, Stouthamer, Suen, Teixeira de Mattos, Tempest, Tempest, Ungerfeld, van Hijum, Van Hoven, Van Kessel, Van Kessel, Van Soest, Van Urk, Vandehaar, Walker, Wallace, Wallace, Wang, Weimer, Weimer, Weimer, Wells, Wells, White, Wilkinson, Williams, Williams, Yang, Ze, Zhou   +158 more
core   +2 more sources