Results 51 to 60 of about 498,441 (308)

Temperature and time-dependent effects of delayed blood processing on oxylipin concentrations in human plasma. [PDF]

, 2019
BACKGROUND:Oxidized derivatives of polyunsaturated fatty acids, collectively known as oxylipins, are labile bioactive mediators with diverse roles in human physiology and pathology.
Gibson, Robert A, Horowitz, Mark S, Majchrzak-Hong, Sharon F, Makrides, Maria, Muhlhausler, Beverly S, Ramsden, Christopher E, Taha, Ameer Y, Yuan, Zhi-Xin, Zamora, Daisy   +8 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Analysis of Pesticide Residues on Fruit Using Swab Spray Ionization Mass Spectrometry

Molecules, 2023
The vast quantity and high variety of pesticides globally used in agriculture entails considerable risks for the environment and requires ensuring the safety of food products.
Thomas Michael Muggli, Stefan Schürch
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Fluocell for Ratiometric and High-Throughput Live-Cell Image Visualization and Quantitation

Frontiers in Physics, 2019
Spatiotemporal regulation of molecular activities dictates cellular function and fate. Investigation of dynamic molecular activities in live cells often requires the visualization and quantitation of fluorescent ratio image sequences with subcellular ...
Qin Qin, Shannon Laub, Yiwen Shi, Mingxing Ouyang, Qin Peng, Jin Zhang, Yingxiao Wang, Shaoying Lu, Shaoying Lu   +8 more
doaj   +1 more source

Quantitative Capillary Electrophoresis for Analysis of Extracellular Vesicles (EVqCE)

Separations, 2021
Extracellular Vesicles (EVs) gained significant interest within the last decade as a new source of biomarkers for the early detection of diseases and a promising tool for therapeutic applications.
Yuchu Dou, Lixuan Ren, Prabir Kumar Kulabhusan, Emil A. Zaripov, Maxim V. Berezovski   +4 more
doaj   +1 more source

Current challenges in software solutions for mass spectrometry-based quantitative proteomics [PDF]

, 2012
This work was in part supported by the PRIME-XS project, grant agreement number 262067, funded by the European Union seventh Framework Programme; The Netherlands Proteomics Centre, embedded in The Netherlands Genomics Initiative; The Netherlands ...
A Alexandridou, A Gruhler, A Leitner, A Michalski, A Panchaud, A Thompson, A Wolf-Yadlin, AD Polpitiya, AHP America, AI Nesvizhskii, AI Nesvizhskii, AI Nesvizhskii, AJR Heck, Albert J. R. Heck, AM Mayampurath, B Breukelen van, B Carrillo, B Ma, B Macek, B Schwanhäusser, B Zybailov, BAP Roxas, Bas van Breukelen, BO Keller, C Christin, C Ji, C Kumar, CH Becker, CK Frese, C–C Tsou, D Chelius, D Hoof Van, D MacDougall, D Tsur, D Valkenborg, DH Lundgren, DK Han, DL Swaney, DL Tabb, DL Tabb, DM Good, DN Perkins, E Deutsch, E Qeli, EL Hendrickson, G Audi, GL Finney, H Lam, H Lam, H Liu, H Steen, H Steen, I Beer, IP Shadforth, J Cox, J Cox, J Elias, J Gouw, J Grossmann, J Klimek, J Listgarten, J Meija, J Rappsilber, J Seidler, J Zhang, JC Silva, JF Kellie, JF Timms, JV Olsen, K Flikka, K Kultima, K Podwojski, KA Neilson, KC Hansen, KL Simpson, L Martens, L Ting, LF Waanders, LK Iwai, LN Mueller, M Bantscheff, M Bantscheff, M Bern, M Junqueira, M Kohl, M Mann, M Sandin, M Senko, M Unlü, M Vandenbogaert, MA Baldwin, MA Grobei, MA Kuzyk, MC Codrea, ME Belov, ME Sardiu, MH Elliott, MJ MacCoss, MM Savitski, MW Duncan, N Colaert, N Mischerikow, N Wang, NM Griffin, OA Mirgorodskaya, P Lu, P Mallick, P Mortensen, Pedro R. Cutillas, Peter R. Baker, PJ Boersema, PL Ross, PR Baker, PR Cutillas, PR Cutillas, R Aebersold, R Clarke, R Matthiesen, R Matthiesen, R Purves, R Usaite, R Zhang, RA Bradshaw, RD Smith, RE Moore, RJ Chalkley, RJ Chalkley, RJ Jacob, S Cappadona, S Cappadona, S Carr, S Dasari, S Houel, S Julka, S Ong, S-E Ong, SA Beausoleil, SA Gerber, Salvatore Cappadona, SJ Callister, SK Park, SP Gygi, SY Ow, T Shinkawa, TM Annesley, TS Collier, TT Aye, V Faca, V Lange, VG Tusher, VP Andreev, W Weiss, W Yan, W Zhu, WM Old, WX Schulze, X Yang, Y Ishihama, Y Oda, YJ Kim, Z Khan, Z Khan, Z-Q Ma   +162 more
core   +2 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

UTE MRI technical developments and applications in osteoporosis: a review

Frontiers in Endocrinology
Osteoporosis (OP) is a metabolic bone disease that affects more than 10 million people in the USA and leads to over two million fractures every year. The disease results in serious long-term disability and death in a large number of patients.
Soo Hyun Shin, Hee Dong Chae, Hee Dong Chae, Arya Suprana, Arya Suprana, Saeed Jerban, Eric Y. Chang, Eric Y. Chang, Lingyan Shi, Robert L. Sah, Jeremy H. Pettus, Gina N. Woods, Jiang Du, Jiang Du, Jiang Du   +14 more
doaj   +1 more source

Hybrid Imaging for Patient-Specific Dosimetry in Radionuclide Therapy

Diagnostics, 2015
Radionuclide therapy aims to treat malignant diseases by systemic administration of radiopharmaceuticals, often using carrier molecules such as peptides and antibodies.
Michael Ljungberg, Katarina Sjögreen Gleisner   +1 more
doaj   +1 more source