Results 41 to 50 of about 35,351 (202)

Current developments of metal- and metalloid-based quinoline compounds as leishmanicidal agents

Frontiers in Chemistry
The quinoline moiety represents an important scaffold for the development of leishmanicidal agents. In particular, its hybridization with metal/metalloids has generated highly active compounds that are, in some cases, highly selective against ...
Edgar Del Carpio, Lino Hernández, Vito Lubes, Francisco Jourdan, Hugo Cerecetto, Hugo Cerecetto, Gonzalo Scalese, Gonzalo Scalese, Dinorah Gambino, Angel H. Romero   +9 more
doaj   +1 more source

2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
In this study, different assortments of 2-arylquinolines and 2,6-diarylquinolines have been developed. Recently, we have developed a new series of 6,7-dimethoxy-4-alkoxy-2-arylquinolines as Topoisomerase I (TOP1) inhibitors with potent anticancer ...
Mostafa M. Elbadawi, Wagdy M. Eldehna, Amer Ali Abd El-Hafeez, Warda R. Somaa, Amgad Albohy, Sara T. Al-Rashood, Keli K. Agama, Eslam B. Elkaeed, Pradipta Ghosh, Yves Pommier, Manabu Abe   +10 more
doaj   +1 more source

A rational strategy to optimize photodrugs by Molecular Dynamics simulations for killing drug‐resistant Gram‐negative bacteria

AIChE Journal, EarlyView.
Abstract Antimicrobial resistance has become a major threat to human health, particularly for Gram‐negative bacteria such as Acinetobacter baumannii and Klebsiella pneumoniae. Disruption of membrane integrity is regarded as a promising antimicrobial strategy that does not induce distinct drug resistance, while increasing the internalization of drug ...
Lei Hao, Yeonho Song, Cheng Zhang, Yumei Wang, Haoying Ge, Wen Sun, Jingyun Wang, Jun Soo Kim, Xiaojun Peng, Juyoung Yoon, Haidong Li   +10 more
wiley   +1 more source

Unusual Product Distribution from Friedländer Reaction of Di- and Triacetylbenzenes with 3-Aminonaphthalene-3-Carbaldehyde and Properties of New Benzo[g]quinoline-Derived Aza-aromatics

Molecules, 2014
The Friedländer reactions of acetylbenzenes and 2-acetylpyridine with 3-aminonaphthalene-2-carbaldehyde afforded the corresponding 2-phenylbenzo[g]quinoline and 2-(pyrid-2-yl)benzo[g]quinoline, respectively.
Moinul Karim, Yurngdong Jahng
doaj   +1 more source

Facile synthesis of novel quinolin-8-amine derivatives: crystallographic study, in silico and antifungal investigation

Chemical and Biological Technologies in Agriculture
Background Quinoline, an important nitrogen-containing heterocycle, is frequently found in both natural and synthetic compounds. Numerous quinoline derivatives have been developed as commercial pharmaceuticals and pesticides. Due to quinoline derivatives
Jian-Ying Tong, Li-Jing Min, Na-Bo Sun, Hong-Ke Wu, Shu-Jing Yu, Qiang Bian, Xing-Hai Liu   +6 more
doaj   +1 more source

Highly efficient electrochemiluminescence of quinoline and isoquinoline in aqueous solution

Electrochemistry Communications, 2019
This paper reports for the first time the strong cathodic electrochemiluminescence (ECL) behavior of quinoline, isoquinoline and their derivatives in aqueous solution with K2S2O8 as coreactant. The effects of K2S2O8 concentration, pH and scan rate on the
Xiangxiang Qin, Xia Xu, Jing Lu, Yinggui Zhu   +3 more
doaj   +1 more source

Crystalline Quinolinate Phosphoribosyltransferase

Journal of Biological Chemistry, 1965
Abstract Quinolinate phosphoribosyltransferase catalyzes the formation of nicotinic acid mononucleotide, carbon dioxide, and inorganic pyrophosphate from quinolinic acid and 5-phosphoribosyl 1-pyrophosphate. The enzyme has a molecular weight of 165,000 and can be irreversibly dissociated into inactive protein units with a molecular weight of 54,000 ...
P M, Packman, W B, Jakoby
openaire   +2 more sources

Production and characterization of graphene-based nanocomposites of different natures and their applications in aqueous quinoline adsorption: A comparative study

Case Studies in Chemical and Environmental Engineering
Quinoline (QN) is a basic nitrogenous compound normally present in the wastewater from petroleum industry, being a toxic and harmful contaminant of emerging concern.
Marcela Bino da Silva Santos, Bruna Figueiredo do Nascimento, Marcos Gomes Ghislandi, Caroline Maria Bezerra de Araujo, Maurício Alves da Motta Sobrinho   +4 more
doaj   +1 more source

Quinoline-Based Hybrid Compounds with Antimalarial Activity

Molecules, 2017
The application of quinoline-based compounds for the treatment of malaria infections is hampered by drug resistance. Drug resistance has led to the combination of quinolines with other classes of antimalarials resulting in enhanced therapeutic outcomes ...
Xhamla Nqoro, Naki Tobeka, Blessing A. Aderibigbe   +2 more
doaj   +1 more source

Syntheses and crystal structures of a new pyrazine dicarboxamide ligand, N2,N3-bis(quinolin-8-yl)pyrazine-2,3-dicarboxamide, and of a copper perchlorate binuclear complex

Acta Crystallographica Section E: Crystallographic Communications, 2020
The title pyrazine dicarboxamide ligand, N2,N3-bis(quinolin-8-yl)pyrazine-2,3-dicarboxamide (H2L1), C24H16N6O2, has a twisted conformation with the outer quinoline groups being inclined to the central pyrazine ring by 9.00 (6) and 78.67 (5)°, and by 79 ...
Dilovan S. Cati, Helen Stoeckli-Evans
doaj   +1 more source