Results 21 to 30 of about 49,482 (250)

In Silico Study of Coumarins and Quinolines Derivatives as Potent Inhibitors of SARS-CoV-2 Main Protease

Frontiers in Chemistry, 2021
The pandemic that started in Wuhan (China) in 2019 has caused a large number of deaths, and infected people around the world due to the absence of effective therapy against coronavirus 2 of the severe acute respiratory syndrome (SARS-CoV-2).
Osvaldo Yañez, Osvaldo Yañez, Osvaldo Yañez, Manuel Isaías Osorio, Manuel Isaías Osorio, Eugenio Uriarte, Eugenio Uriarte, Carlos Areche, William Tiznado, José M. Pérez-Donoso, Olimpo García-Beltrán, Fernando González-Nilo   +11 more
doaj   +1 more source

A Convenient One-Pot Preparation of 2-Methyl-3-(phenylthio- methyl)quinolines from Morita-Baylis-Hillman Adducts and Their Oxidation to the Corresponding Sulfones

Molecules, 2012
A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl)quinolines from Morita-Baylis-Hillman adducts via conjugate addition of thiols followed by reductive cyclization with Fe/AcOH was developed. The 2-methyl-3-(phenylthiomethyl)quinolines were
Ching-Fa Yao, Veerababurao Kavala, Chintakunta Ramesh, Po-Min Lei, Chun-Wei Kuo   +4 more
doaj   +1 more source

Quinolines-Based SARS-CoV-2 3CLpro and RdRp Inhibitors and Spike-RBD-ACE2 Inhibitor for Drug-Repurposing Against COVID-19: An in silico Analysis

Frontiers in Microbiology, 2020
The novel coronavirus SARS-CoV-2 disease “COVID-19” emerged in China and rapidly spread to other countries; due to its rapid worldwide spread, the WHO has declared this as a global emergency. As there is no specific treatment prescribed to treat COVID-19,
Rajaiah Alexpandi, J. F. De Mesquita, S. K. Pandian, A. V. Ravi   +3 more
semanticscholar   +1 more source

TMSBr-Promoted Cascade Cyclization of ortho-Propynol Phenyl Azides for the Synthesis of 4-Bromo Quinolines and Its Applications

Molecules, 2019
Difficult-to-access 4-bromo quinolines are constructed directly from easily prepared ortho-propynol phenyl azides using TMSBr as acid-promoter. The cascade transformation performs smoothly to generate desired products in moderate to excellent yields with
Fengyan Jin, Tao Yang, Xian-Rong Song, Jiang Bai, Ruchun Yang, Haixin Ding, Qiang Xiao   +6 more
doaj   +1 more source

Therapeutic Activity of a Topical Formulation Containing 8-Hydroxyquinoline for Cutaneous Leishmaniasis

Pharmaceutics, 2023
Cutaneous leishmaniasis exhibits a wide spectrum of clinical manifestations; however, only a limited number of drugs are available and include Glucantime® and amphotericin B, which induce unacceptable side effects in patients, limiting their use.
Sarah Kymberly Santos de Lima, Ítalo Novaes Cavallone, Dolores Remedios Serrano, Brayan J. Anaya, Aikaterini Lalatsa, Márcia Dalastra Laurenti, João Henrique Ghilardi Lago, Dalete Christine da Silva Souza, Gabriela Pustiglione Marinsek, Beatriz Soares Lopes, Renata de Britto Mari, Luiz Felipe Domingues Passero   +11 more
doaj   +1 more source

Application of Heteropoly Acids as Heterogeneous and Recyclable Catalysts for Friedländer Synthesis of Quinolines

E-Journal of Chemistry, 2010
New convenient conditions for the Friedländer synthesis of quinolines are described. Quinolines were readily prepared in the presence of heteropolyacids as heterogeneous and recyclable catalysts in good yields.
Majid M. Heravi, Negar Mokhtari Haj, Bita Baghernejad, Y. SH. Beheshtia, Fatemeh F. Bamoharram   +4 more
doaj   +1 more source

Multicomponent Synthesis of 4-Aryl-4,9-dihydro-1H-pyrazolo[3,4-b]quinolines Using L-Proline as a Catalyst—Does It Really Proceed?

Molecules, 2023
Looking for effective synthetic methods for 1H-pyrazolo[3,4-b]quinolines preparation, we came across a procedure where, in a three-component reaction catalysed by L-proline, 4-aryl-4,9-dihydro-1H-pyrazolo[3,4-b]quinolines are formed.
Andrzej Danel, Elżbieta Porębska, Kacper Markiel, Oleksii Havrysh, Mateusz Kucharek, Arkadiusz Gut, Tomasz Uchacz   +6 more
doaj   +1 more source

Quinolin-3-amine [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
In the crystal structur of the achiral title compound, C(9)H(8)N(2), N-H⋯N hydrogen bonds connect the mol-ecules into zigzag chains in [100]. Weak inter-molecular N-H⋯π inter-actions further consolidate the crystal packing.
Islor, Arun M., Chandrakantha, B., Shetty, Prakash, Gerber, Thomas, Hosten, Eric, Betz, Richard   +5 more
openaire   +2 more sources

Quinoline-2-carbaldehyde [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
The title compound, C(10)H(7)NO, crystallizes with two almost planar mol-ecules (A and B) in the asymmetric unit (r.m.s. deviations = 0.018 and 0.020 Å). In the crystal, the A mol-ecules are linked by weak C-H⋯O inter-actions, thereby generating C(9) [001] chains. The B mol-ecules do not exhibit any directional bonding inter-actions.
Martin O. Onani, William M. Motswainyana
openaire   +3 more sources

Synthesis of Azuleno[2,1-b]quinolones and Quinolines via Brønsted Acid-Catalyzed Cyclization of 2-Arylaminoazulenes

Molecules, 2023
Quinolone and quinoline derivatives are frequently found as substructures in pharmaceutically active compounds. In this paper, we describe a procedure for the synthesis of azuleno[2,1-b]quinolones and quinolines from 2-arylaminoazulene derivatives, which
Taku Shoji, Mutsumi Takeuchi, Mayumi Uda, Yukino Ariga, Akari Yamazaki, Ryuta Sekiguchi, Shunji Ito   +6 more
doaj   +1 more source