Quinolinic acid potentially links kidney injury to brain toxicity [PDF]
JCI InsightKidney dysfunction often leads to neurological impairment, yet the complex kidney-brain relationship remains elusive. We employed spatial and bulk metabolomics to investigate a mouse model of rapid kidney failure induced by mouse double minute 2 (Mdm2 ...
Afaf Saliba +21 more
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The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases [PDF]
Biomolecules, 2022 Emerging evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several competing pathways of tryptophan ...
Knut Hestad +3 more
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States of quinolinic acid excess in urine: A systematic review of human studies [PDF]
Frontiers in Nutrition, 2022 IntroductionQuinolinic acid is an intermediate compound derived from the metabolism of dietary tryptophan. Its accumulation has been reported in patients suffering a broad spectrum of diseases and conditions. In this manuscript, we present the results of
Marie Christelle Saade +4 more
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Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder [PDF]
Scientific Reports, 2021 Tryptophan and its catabolites (TRYCATs) have been suggested to link peripheral immune system activation and central neurotransmitter abnormalities with relevance to the etio-pathophysiology of schizophrenia (SZ) and major depressive disorder (MDD).
Flurin Cathomas +4 more
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CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection‐triggered encephalopathy syndromes [PDF]
Annals of Clinical and Translational Neurology, 2023 Objective Infection‐triggered encephalopathy syndromes (ITES) are potentially devastating neuroinflammatory conditions. Although some ITES syndromes have recognisable MRI neuroimaging phenotypes, there are otherwise few biomarkers of disease.
Russell C. Dale +18 more
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CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammationResearch in context [PDF]
EBioMedicine, 2023 Summary: Background: Defining the presence of acute and chronic brain inflammation remains a challenge to clinicians due to the heterogeneity of clinical presentations and aetiologies.
Jingya Yan +25 more
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Identification of kynurenine and quinolinic acid as promising serum biomarkers for drug-induced interstitial lung diseases [PDF]
Respiratory ResearchBackground Drug-induced interstitial lung disease (DILD) is a lung injury caused by various types of drugs and is a serious problem in both clinical practice and drug development.
Yuchen Sun +26 more
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Butyrate ameliorates quinolinic acid–induced cognitive decline in obesity models [PDF]
The Journal of Clinical Investigation, 2023 Obesity is a risk factor for neurodegenerative disease associated with cognitive dysfunction, including Alzheimer’s disease. Low-grade inflammation is common in obesity, but the mechanism between inflammation and cognitive impairment in obesity is ...
Xing Ge +17 more
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Roles for Cationic Residues at the Quinolinic Acid Binding Site of Quinolinate Phosphoribosyltransferase [PDF]
Biochemistry, 2010 Quinolinic acid phosphoribosyltransferase (QAPRTase, EC 2.4.2.19) forms nicotinate mononucleotide (NAMN) from quinolinic acid (QA) and 5-phosphoribosyl 1-pyrophosphate (PRPP). Previously determined crystal structures of QAPRTase.QA and QAPRTase.PA.PRPP complexes show positively charged residues (Arg118, Arg152, Arg175, Lys185, and His188) lining the QA
Zainab Bello, Charles Grubmeyer
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Identification of quinolinic acid-utilizing bacteria.
The Journal of General and Applied Microbiology, 1979 A microorganism utilizing quinolinic acid as sole carbon, nitrogen, and energy sources for growth, and producing a potent activity of quinolinate phosphoribosyltransferase in its cells was isolated. Based on its morphological, cultural, physiological, and biochemical characteristics, including the proper composition of cellular fatty acids, Alcaligenes
Kageaki Kouno +3 more
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