Results 1 to 10 of about 5,008,397 (253)
Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis. [PDF]
PLoS ONE, 2016 BACKGROUND:An increase of plasma kynurenine concentrations, potentially bioactive metabolites of tryptophan, was found in subjects with obesity, resulting from low-grade inflammation of the white adipose tissue.
Marie Favennec +13 more
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Biomolecules, 2022 Emerging evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several competing pathways of tryptophan ...
Knut Hestad +3 more
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Scientific Reports, 2021 Tryptophan and its catabolites (TRYCATs) have been suggested to link peripheral immune system activation and central neurotransmitter abnormalities with relevance to the etio-pathophysiology of schizophrenia (SZ) and major depressive disorder (MDD).
Flurin Cathomas +4 more
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States of quinolinic acid excess in urine: A systematic review of human studies
Frontiers in Nutrition, 2022 IntroductionQuinolinic acid is an intermediate compound derived from the metabolism of dietary tryptophan. Its accumulation has been reported in patients suffering a broad spectrum of diseases and conditions. In this manuscript, we present the results of
Marie Christelle Saade +4 more
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Butyrate ameliorates quinolinic acid–induced cognitive decline in obesity models
The Journal of Clinical Investigation, 2023 Obesity is a risk factor for neurodegenerative disease associated with cognitive dysfunction, including Alzheimer’s disease. Low-grade inflammation is common in obesity, but the mechanism between inflammation and cognitive impairment in obesity is ...
Xing Ge +17 more
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PLoS ONE, 2015 BackgroundThe aim of this exploratory study is to gain for the first time a more comprehensive picture of the impact of changes of quinolinic acid concentrations on depressive symptomatology during and after IFN-α therapy.MethodsThe quinolinic acid ...
Andreas Baranyi +5 more
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Roles for Cationic Residues at the Quinolinic Acid Binding Site of Quinolinate Phosphoribosyltransferase [PDF]
Biochemistry, 2010 Quinolinic acid phosphoribosyltransferase (QAPRTase, EC 2.4.2.19) forms nicotinate mononucleotide (NAMN) from quinolinic acid (QA) and 5-phosphoribosyl 1-pyrophosphate (PRPP). Previously determined crystal structures of QAPRTase.QA and QAPRTase.PA.PRPP complexes show positively charged residues (Arg118, Arg152, Arg175, Lys185, and His188) lining the QA
Zainab I. Bello, Charles Grubmeyer
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Identification of quinolinic acid-utilizing bacteria.
The Journal of General and Applied Microbiology, 1979 A microorganism utilizing quinolinic acid as sole carbon, nitrogen, and energy sources for growth, and producing a potent activity of quinolinate phosphoribosyltransferase in its cells was isolated. Based on its morphological, cultural, physiological, and biochemical characteristics, including the proper composition of cellular fatty acids, Alcaligenes
Kageaki Kouno +3 more
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Biochemical characterization of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv and inhibition of its activity by pyrazinamide. [PDF]
PLoS ONE, 2014 Quinolinic acid phosphoribosyltransferase (QAPRTase, EC 2.4.2.19) is a key enzyme in the de novo pathway of nicotinamide adenine dinucleotide (NAD) biosynthesis and a target for the development of new anti-tuberculosis drugs.
Hyun Kim +3 more
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A DIRECT MICROBIOLOGICAL ASSAY FOR QUINOLINIC ACID [PDF]
Journal of Biological Chemistry, 1951 William B. Jakoby, David M. Bonner
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