Quinolinic acid potentially links kidney injury to brain toxicity [PDF]
JCI InsightKidney dysfunction often leads to neurological impairment, yet the complex kidney-brain relationship remains elusive. We employed spatial and bulk metabolomics to investigate a mouse model of rapid kidney failure induced by mouse double minute 2 (Mdm2 ...
Afaf Saliba +21 more
doaj +4 more sources
The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases [PDF]
Biomolecules, 2022 Emerging evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several competing pathways of tryptophan ...
Knut Hestad +3 more
doaj +2 more sources
States of quinolinic acid excess in urine: A systematic review of human studies [PDF]
Frontiers in Nutrition, 2022 IntroductionQuinolinic acid is an intermediate compound derived from the metabolism of dietary tryptophan. Its accumulation has been reported in patients suffering a broad spectrum of diseases and conditions. In this manuscript, we present the results of
Marie Christelle Saade +4 more
doaj +2 more sources
Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder [PDF]
Scientific Reports, 2021 Tryptophan and its catabolites (TRYCATs) have been suggested to link peripheral immune system activation and central neurotransmitter abnormalities with relevance to the etio-pathophysiology of schizophrenia (SZ) and major depressive disorder (MDD).
Flurin Cathomas +4 more
doaj +2 more sources
CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection‐triggered encephalopathy syndromes [PDF]
Annals of Clinical and Translational Neurology, 2023 Objective Infection‐triggered encephalopathy syndromes (ITES) are potentially devastating neuroinflammatory conditions. Although some ITES syndromes have recognisable MRI neuroimaging phenotypes, there are otherwise few biomarkers of disease.
Russell C. Dale +18 more
doaj +2 more sources
PLoS ONE, 2015 BackgroundThe aim of this exploratory study is to gain for the first time a more comprehensive picture of the impact of changes of quinolinic acid concentrations on depressive symptomatology during and after IFN-α therapy.MethodsThe quinolinic acid ...
Andreas Baranyi +5 more
doaj +3 more sources
LC-MS/MS Detection of Tryptophan, Kynurenine, Kynurenic Acid, and Quinolinic Acid in Urine Samples from Drug-Positive and Illicit Drug-Negative Patients with a Known History of Substance Use Disorder [PDF]
MetabolitesIntroduction: Currently, there are few tools for monitoring recovery in substance use disorder. As substance use has increased in prevalence, tools for measuring recovery are needed to improve therapeutic outcomes.
Lindsey Contella +8 more
doaj +2 more sources
Identification of kynurenine and quinolinic acid as promising serum biomarkers for drug-induced interstitial lung diseases [PDF]
Respiratory ResearchBackground Drug-induced interstitial lung disease (DILD) is a lung injury caused by various types of drugs and is a serious problem in both clinical practice and drug development.
Yuchen Sun +26 more
doaj +2 more sources
CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation. [PDF]
EBioMedicine, 2023 Yan J +25 more
europepmc +2 more sources