Results 91 to 100 of about 16,454 (258)

Biochemical characterization of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv and inhibition of its activity by pyrazinamide. [PDF]

PLoS ONE, 2014
Quinolinic acid phosphoribosyltransferase (QAPRTase, EC 2.4.2.19) is a key enzyme in the de novo pathway of nicotinamide adenine dinucleotide (NAD) biosynthesis and a target for the development of new anti-tuberculosis drugs.
Hyun Kim, Keigo Shibayama, Emiko Rimbara, Shigetarou Mori   +3 more
doaj   +1 more source

Monoamine oxidase A upregulated by chronic intermittent hypoxia activates indoleamine 2,3-dioxygenase and neurodegeneration [PDF]

, 2017
published_or_final_versio
Fung, ML, Lam, CS, LI, J, Tipoe, GL, Youdim, MBH   +4 more
core   +1 more source

Disruption of Gut Microbiota‐Mediated De Novo NAD+ Synthesis Contributes to the Development of Polycystic Ovary Syndrome

Advanced Science, Volume 12, Issue 45, December 4, 2025.
This study demonstrates that patients with PCOS exhibit altered gut microbial profiles, and FMT from PCOS patients induces PCOS‐like symptoms in mice. Specifically, gut dysbiosis reduces 3‐HAA levels in the context of PCOS. Administration of 3‐HAA to mice alleviates PCOS by promoting de novo NAD+ synthesis.
Ke Chen, Huafeng Geng, Yang Zheng, Hongyang Xie, Rui Qin, Junyang Chen, Cong Ye   +6 more
wiley   +1 more source

Function of BID - a molecule of the bcl-2 family - in ischemic cell death in the brain [PDF]

, 2002
Mitochondrial mechanisms, particularly the release of cytochrome c, play a role in the death of nerve and glial cells in cerebral ischemia. We have currently investigated whether BID, a proapoptotic molecule of the bcl-2 family and promoter of the ...
Amin-Hanjani, Sepideh, Korsmeyer, Stanley J., Moskowitz, Michael A., Plesnila, Nikolaus, Qiu, Jianhua, Zinkel, Sandra   +5 more
core   +1 more source

Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis [PDF]

, 2016
The kynurenine pathway (KP) is the major metabolic pathway of the essential amino acid tryptophan (TRP). Stimulation by inflammatory molecules, such as interferon-γ (IFN-γ), is the trigger for induction of the KP, driving a complex cascade of production ...
Bianca Varney, Bruce J. Brew, Bruce J. Brew, Bruce J. Brew, Chai K. Lim, Gayathri Sundaram, Mei Li Ng, Michael D. Lovelace, Michael D. Lovelace, Nunzio Franco, Saparna Pai   +10 more
core   +3 more sources

(Quinoline-2-carboxylato-κO)(quinoline-2-carboxylic acid-κO)bis(quinoline-2-carboxylic acid-κ²N,O)potassium [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
The K atom in the title complex, [K(C(10)H(6)NO(2))(C(10)H(7)NO(2))(3)], lies on a twofold rotation axis that relates one N, O-chelating quinoline-2-carb-oxy-lic acid to the other ; their N and O atoms are cis to each other in the distorted octa-hedral coordination geometry.
openaire   +1 more source

QUINOLINIC ACID METABOLISM

Journal of Biological Chemistry, 1949
L.M. Henderson, G.B. Ramasarma
  +5 more sources

Pyridinedicarboxylic Acid Derivatives of Dichlorobis(cyclopentadienyl)titanium(IV)

E-Journal of Chemistry, 2012
Reactions of dichlorobis(cyclopentadienyl)titanium(IV) with pyridine dicarboxylic acids viz. quinolinic acid (QAH2), 2,4-pyridine dicarboxylic acid (PAH2), isocinchomeronic acid (IAH2), cinchomeronic acid (CAH2) and dinicotinic acid (DAH2) were carried ...
Satish C. Dixit, Rohit K. Singh
doaj   +1 more source

Plasma Levels of Kynurenines and B‐vitamins across Diagnostic Phases of Dementia and in Healthy Controls [PDF]

Alzheimers Dement
Abstract Background The tryptophan‐kynurenine pathway may play a role in cognitive decline in both neurodegenerative and cerebrovascular disorders. However, clinical studies investigating kynurenines so far have generally been small, and studies looking into prodromal disease stages are scarce.
Bakker L, Köhler S, Choe K, van den Hove D, Kenis G, Eussen S, Schram M, van Oostenbrugge R, Staals J, Rutten B, Ulvik A, Ueland P, Verhey F, Ramakers I.   +13 more
europepmc   +2 more sources

TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria [PDF]

, 2016
The 18-kDa translocator protein (TSPO) localizes in the outer mitochondrial membrane (OMM) of cells and is readily up-regulated under various pathological conditions such as cancer, inflammation, mechanical lesions and neurological diseases. Able to bind
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core   +1 more source