Results 91 to 100 of about 16,555 (256)

Changes in Metabolites and Microbial Communities in Follicular Fluid Associated With Ovarian Function in Patients With Polycystic Ovary Syndrome

MedComm, Volume 7, Issue 2, February 2026.
Based on the integrated analysis of follicular fluid metabolites and microbial communities in patients with PCOS, this study reveals significant dysregulation in the follicular microenvironment. Key metabolites including D‐glucose and 25‐hydroxycholesterol show marked alterations, while microbial communities such as Alicyclobacillus and Terrimonas ...
Manfei Si, Sen Yan, Shu Ding, Rui Liu, Xianglei Xiong, Jie Qiao, Xinyu Qi   +6 more
wiley   +1 more source

Function of BID - a molecule of the bcl-2 family - in ischemic cell death in the brain [PDF]

, 2002
Mitochondrial mechanisms, particularly the release of cytochrome c, play a role in the death of nerve and glial cells in cerebral ischemia. We have currently investigated whether BID, a proapoptotic molecule of the bcl-2 family and promoter of the ...
Amin-Hanjani, Sepideh, Korsmeyer, Stanley J., Moskowitz, Michael A., Plesnila, Nikolaus, Qiu, Jianhua, Zinkel, Sandra   +5 more
core   +1 more source

Comparative multi‐omics in female mice reveals tissue‐specific vulnerabilities to chronic alcohol intake

Alcohol, Clinical and Experimental Research, Volume 50, Issue 2, February 2026.
Using mice, we applied multi‐omics to compare liver and skeletal muscle after chronic alcohol consumption. The liver responded more strongly across genes, proteins, and metabolites, with a lowered PC:PE ratio. Muscle showed inflammation, extracellular matrix activation, impaired mitochondrial energetics, and an elevated PC:PE ratio. Lipidomics affected
Craig R. G. Willis, Muni Swamy Ganjayi, Austin M. Brown, Samantha E. Moser, Nathaniel J. Szewczyk, Brian C. Clark, Cory W. Baumann   +6 more
wiley   +1 more source

Biochemical characterization of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv and inhibition of its activity by pyrazinamide. [PDF]

PLoS ONE, 2014
Quinolinic acid phosphoribosyltransferase (QAPRTase, EC 2.4.2.19) is a key enzyme in the de novo pathway of nicotinamide adenine dinucleotide (NAD) biosynthesis and a target for the development of new anti-tuberculosis drugs.
Hyun Kim, Keigo Shibayama, Emiko Rimbara, Shigetarou Mori   +3 more
doaj   +1 more source

Can manipulation of differentiation conditions eliminate proliferative cells from a population of ES cell-derived forebrain cells? [PDF]

, 2016
There is preliminary evidence that implantation of primary fetal striatal cells provides functional benefit in patients with Huntington’s disease, a neurodegenerative condition resulting in loss of medium-sized spiny neurons (MSN) of the striatum ...
Allen, Nicholas Denby, Kelly, Claire M., Precious, Sophie V., Rosser, Anne Elizabeth   +3 more
core   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, Volume 16, Issue 1, Page 52-67, January 2026.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease

Journal of Neuroinflammation, 2019
Background Blood markers indicative of neurodegeneration (neurofilament light chain; NFL), Alzheimer’s disease amyloid pathology (amyloid-β; Aβ), and neuroinflammation (kynurenine pathway; KP metabolites) have been investigated independently in ...
Pratishtha Chatterjee, Henrik Zetterberg, Kathryn Goozee, Chai K. Lim, Kelly R. Jacobs, Nicholas J. Ashton, Abdul Hye, Steve Pedrini, Hamid R. Sohrabi, Tejal Shah, Prita R. Asih, Preeti Dave, Kaikai Shen, Kevin Taddei, David B. Lovejoy, Gilles J. Guillemin, Kaj Blennow, Ralph N. Martins   +17 more
doaj   +1 more source

Cerebrospinal Fluid Biomarkers for Huntington's Disease. [PDF]

, 2016
Cerebrospinal fluid (CSF) is enriched in brain-derived components and represents an accessible and appealing means of interrogating the CNS milieu to study neurodegenerative diseases and identify biomarkers to facilitate the development of novel ...
Byrne, LM, Wild, EJ
core   +1 more source

Single‐Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma

Advanced Science, Volume 13, Issue 5, 27 January 2026.
KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen, Liming Sun, Jiajun Chen, Zi Ye, Xuqiang Zhu, Hongjiang Li, Lixin Wu, Guohua Zhao, Qinghao Zhang, Guangyi Jiang, Yuchen Ji, Yake Xue, Hongwei Li, Ruokun Chen, Hongwei Zheng, Rong Zeng, Dongming Yan, Yong Zhang, Xueyuan Li, Jing Yan   +19 more
wiley   +1 more source

Pyridinedicarboxylic Acid Derivatives of Dichlorobis(cyclopentadienyl)titanium(IV)

E-Journal of Chemistry, 2012
Reactions of dichlorobis(cyclopentadienyl)titanium(IV) with pyridine dicarboxylic acids viz. quinolinic acid (QAH2), 2,4-pyridine dicarboxylic acid (PAH2), isocinchomeronic acid (IAH2), cinchomeronic acid (CAH2) and dinicotinic acid (DAH2) were carried ...
Satish C. Dixit, Rohit K. Singh
doaj   +1 more source