Quinolinic acid induces alterations in neuronal subcellular compartments, blocks autophagy flux and activates necroptosis and apoptosis in rat striatum. [PDF]
, 2022 Carlos Alfredo Silva‐Islas +6 more
openalex +1 more source
Alzheimer's &Dementia, Volume 21, Issue S5, December 2025.Abstract Background Chronic Unpredictable Stress (CUS) is a widely used model to induce cognitive impairments and neurodegeneration through the activation of the kynurenine (KYN) pathway. Long‐term stress causes the production of more cortisol, which activates microglia and raises quinolinic acid (QA).
Girdhari Lal Gupta, Nikita Patil
wiley +1 more source
Relation of the kynurenine pathway with cognitive functioning and differences in patients with cognitive impairment or dementia: a systematic review and meta‐analysis [PDF]
Alzheimers DementAbstract Background The kynurenine pathway (KP) is associated with pathophysiological processes underlying dementia, but results from clinical studies are contradictory. Therefore, this systematic review and meta‐analysis summarized the available evidence for differences in KP metabolites in patients with cognitive impairment compared to cognitively ...
Bakker L +8 more
europepmc +2 more sources
Can manipulation of differentiation conditions eliminate proliferative cells from a population of ES cell-derived forebrain cells? [PDF]
, 2016 There is preliminary evidence that implantation of primary fetal striatal cells provides functional benefit in patients with Huntington’s disease, a neurodegenerative condition resulting in loss of medium-sized spiny neurons (MSN) of the striatum ...
Allen, Nicholas Denby +3 more
core +1 more source
Role of Tryptophan Metabolism in Cancer
Cancer Innovation, Volume 4, Issue 6, December 2025.This review systematically summarizes the functions and related mechanisms of tryptophan metabolism in various tumor types. It presents the latest progress in this field in a comprehensive manner and combines this with clinical practice to offer a new perspective on tumor treatment.
Zhehao Cui +5 more
wiley +1 more source
Cerebrospinal Fluid Biomarkers for Huntington's Disease. [PDF]
, 2016 Cerebrospinal fluid (CSF) is enriched in brain-derived components and represents an accessible and appealing means of interrogating the CNS milieu to study neurodegenerative diseases and identify biomarkers to facilitate the development of novel ...
Byrne, LM, Wild, EJ
core +1 more source
Genetically engineered mesenchymal stem cells as a proposed therapeutic for Huntington's disease. [PDF]
, 2011 There is much interest in the use of mesenchymal stem cells/marrow stromal cells (MSC) to treat neurodegenerative disorders, in particular those that are fatal and difficult to treat, such as Huntington's disease.
Annett, Geralyn +14 more
core +3 more sources
Some New Derivatives of Organozirconium(IV) with Pyridinedicarboxylic Acids
E-Journal of Chemistry, 2012 Reactions of dichlorobis(cyclopentadienyl)zirconium(IV) with pyridinedicarboxylic acids viz. quinolinic acids (QAH2), 2,4-pyridine dicarboxylic acid (PAH2), isocinchomeronic acid (IAH2), cinchomeronic acid (CAH2) and dinicotinic acid (DAH2) were carried ...
Satish C. Dixit, Rohit K. Singh
doaj +1 more source
Serum Metabolomic Profiling of Piglets Infected with Virulent Classical Swine Fever Virus [PDF]
, 2017 Citation: Gong, W. J., Jia, J. J., Zhang, B. K., Mi, S. J., Zhang, L., Xie, X. M., . . . Tu, C. C. (2017). Serum Metabolomic Profiling of Piglets Infected with Virulent Classical Swine Fever Virus. Frontiers in Microbiology, 8, 14. doi:10.3389/fmicb.2017.
Bikai Zhang +10 more
core +2 more sources
Narcolepsy: autoimmunity, effector T cell activation due to infection, or T cell independent, major histocompatibility complex class II induced neuronal loss? [PDF]
, 2017 Human narcolepsy with cataplexy is a neurological disorder, which develops due to a deficiency in hypocretin producing neurons in the hypothalamus. There is a strong association with human leucocyte antigens HLA-DR2 and HLA-DQB1*0602.
Bassetti, Claudio L. +5 more
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