Monoamine oxidase A upregulated by chronic intermittent hypoxia activates indoleamine 2,3-dioxygenase and neurodegeneration [PDF]
, 2017 published_or_final_versio
Fung, ML +4 more
core +1 more source
(Quinoline-2-carboxylato-κO)(quinoline-2-carboxylic acid-κO)bis(quinoline-2-carboxylic acid-κ2N,O)potassium [PDF]
Acta Crystallographica Section E Structure Reports Online, 2010 The K atom in the title complex, [K(C(10)H(6)NO(2))(C(10)H(7)NO(2))(3)], lies on a twofold rotation axis that relates one N, O-chelating quinoline-2-carb-oxy-lic acid to the other ; their N and O atoms are cis to each other in the distorted octa-hedral coordination geometry.
openaire +1 more source
Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology [PDF]
, 2015 Mounting evidence demonstrates that kynurenine metabolism may play an important pathogenic role in the development of multiple neurological and neuropsychiatric disorders.
Jason C. O’Connor, Jennifer M. Parrott
core +2 more sources
Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.Following the MIND diet may support brain health in older adults at risk of cognitive decline by influencing tryptophan (TRP) metabolism. Plasma samples and dietary intake data from the HELI intervention trial were used. Bivariate latent change score modeling analysis showed that greater adherence to the MIND diet was linked to higher tryptophan levels,
Sonja Beers +10 more
wiley +1 more source
The mysterious case of the C. elegans gut granule: death fluorescence, anthranilic acid and the kynurenine pathway [PDF]
, 2013 Gut granules are lysosome-like organelles with acidic interiors that are found in large numbers within the intestine of the nematode Caenorhabditis elegans.
Coburn, C, Gems, D
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FASEB BioAdvances, Volume 8, Issue 1, January 2026.Dysbiosis‐induced alterations in microbial metabolite production promote intestinal barrier disruption and systemic inflammation, driving insulin resistance and metabolic dysfunction. Microbiota‐targeting therapies represent promising approaches to restore host metabolic health.
Mohamad Al Qassab +10 more
wiley +1 more source
M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus [PDF]
, 2016 Monoamine oxidases (MAO), downstream targets of glucocorticoid, maintain the turnover and homeostasis of monoamine neurotransmitters; yet, its pathophysiological role in monoamine deficiency, oxidative stress and neuroinflammation remains controversial ...
Fung, ML +4 more
core +1 more source
Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis [PDF]
, 2016 The kynurenine pathway (KP) is the major metabolic pathway of the essential amino acid tryptophan (TRP). Stimulation by inflammatory molecules, such as interferon-γ (IFN-γ), is the trigger for induction of the KP, driving a complex cascade of production ...
Bianca Varney +10 more
core +3 more sources
Some New Derivatives of Organozirconium(IV) with Pyridinedicarboxylic Acids
E-Journal of Chemistry, 2012 Reactions of dichlorobis(cyclopentadienyl)zirconium(IV) with pyridinedicarboxylic acids viz. quinolinic acids (QAH2), 2,4-pyridine dicarboxylic acid (PAH2), isocinchomeronic acid (IAH2), cinchomeronic acid (CAH2) and dinicotinic acid (DAH2) were carried ...
Satish C. Dixit, Rohit K. Singh
doaj +1 more source
Genetically engineered mesenchymal stem cells as a proposed therapeutic for Huntington's disease. [PDF]
, 2011 There is much interest in the use of mesenchymal stem cells/marrow stromal cells (MSC) to treat neurodegenerative disorders, in particular those that are fatal and difficult to treat, such as Huntington's disease.
Annett, Geralyn +14 more
core +3 more sources