Results 101 to 110 of about 5,015,403 (283)

Cerebrospinal fluid biomarkers in twins with schizophrenia and bipolar disorder [PDF]

, 2015
Previously identified cerebrospinal fluid (CSF) biomarkers were studied in 37 twins with schizophrenia or bipolar disorder to determine their genetic and environmental properties.
Johansson, Viktoria
core   +1 more source

How pandemics reshape our brain: Common links and targets between long‐haul COVID‐19, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), oxidative stress, and neurodegeneration

Neuroprotection, EarlyView.
Mary E. Herman
wiley   +1 more source

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, Volume 8, Issue 5, Page 798-818, May 2025.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source

Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans

Journal of Neuroinflammation, 2015
During inflammation, the kynurenine pathway (KP) metabolises the essential amino acid tryptophan (TRP) potentially contributing to excitotoxicity via the release of quinolinic acid (QUIN) and 3-hydroxykynurenine (3HK).
E. Yan, Tony Frugier, C. Lim, B. Heng, Gayathri Sundaram, May Tan, J. Rosenfeld, David W. Walker, Gilles J. Guillemin, M. Morganti‐Kossmann   +9 more
semanticscholar   +1 more source

Pyridinedicarboxylic Acid Derivatives of Dichlorobis(cyclopentadienyl)titanium(IV)

E-Journal of Chemistry, 2012
Reactions of dichlorobis(cyclopentadienyl)titanium(IV) with pyridine dicarboxylic acids viz. quinolinic acid (QAH2), 2,4-pyridine dicarboxylic acid (PAH2), isocinchomeronic acid (IAH2), cinchomeronic acid (CAH2) and dinicotinic acid (DAH2) were carried ...
Satish C. Dixit, Rohit K. Singh
doaj   +1 more source

Effects of selctive lesions of the nucleus basalis magnocellularis on working memory in rats. [PDF]

, 2001
The nucleus basalis magnocellularis (NBM) of the rat brain is analogous to the nucleus basalis of Meynert found in humans. Alzheimer's disease patients have working memory impairments, which may be attributable to damage to the basal nucleus of Meynert ...
Noble, Michelle Marie
core   +1 more source

Multi‐Omics Analysis Reveals Disturbances of Purine Metabolism and Glutamate Metabolism in the Hippocampus of Lipopolysaccharide‐Induced Mouse Model of Depression

Brain and Behavior, Volume 15, Issue 5, May 2025.
The study focused on a mouse model of depression induced by lipopolysaccharides (LPS) and employed innovative multi‐omics approaches, including two‐dimensional gel electrophoresis (2‐DE) for proteomics, liquid chromatography–mass spectrometry (LC–MS) for metabolomics, and real‐time polymerase chain reaction (PCR) microarray technology to analyze the ...
Wen‐Wen Li, Rui Xiao, Xue‐Yi Chen, Jun‐Cai Pu, Jian‐Jun Chen, Hai‐Yang Wang, Lan‐Xiang Liu, Dan Li, Yang‐Dong Zhang, Wen‐Xia Li, Peng Xie   +10 more
wiley   +1 more source

Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease

Journal of Neuroinflammation, 2019
Background Blood markers indicative of neurodegeneration (neurofilament light chain; NFL), Alzheimer’s disease amyloid pathology (amyloid-β; Aβ), and neuroinflammation (kynurenine pathway; KP metabolites) have been investigated independently in ...
Pratishtha Chatterjee, Henrik Zetterberg, Kathryn Goozee, Chai K. Lim, Kelly R. Jacobs, Nicholas J. Ashton, Abdul Hye, Steve Pedrini, Hamid R. Sohrabi, Tejal Shah, Prita R. Asih, Preeti Dave, Kaikai Shen, Kevin Taddei, David B. Lovejoy, Gilles J. Guillemin, Kaj Blennow, Ralph N. Martins   +17 more
doaj   +1 more source

Amaranthus spinosus Linn. Extract as an Innovative Strategy to Regulate Biomarkers for Ovarian Hyperthecosis via Circular RNA (hsa‐circ‐0001577): Evidence From Biochemical, Metabolomics, Histological, and Phytochemical Profiling

Food Science &Nutrition, Volume 13, Issue 5, May 2025.
A significant improvement in hormonal and oxidative stress biomarkers was observed in rats treated with Amaranthus spinosus, especially at high doses, after induction of ovarian hyperthecosis. Amaranthus spinosus could be a management approach for ovarian hyperthecosis via regulating circRNA (hsa‐circ‐0001577), disturbed hormonal balance, and ...
Naglaa M. Ammar, Mai O. Kadry, Asmaa S. Abd Elkarim, Reham S. Ibrahim, Ibrahim E. Sallam, Abd El‐Nasser G. El Gendy, Sherif M. Afifi, Tuba Esatbeyoglu, Mohamed A. Farag, Abdelsamed I. Elshamy   +9 more
wiley   +1 more source

The influence of microbiome‐derived amino acids metabolites in shaping the glioma immunosuppressive microenvironment

Interdisciplinary Medicine, Volume 3, Issue 3, May 2025.
Left: The disruption of the balance between carcinogenic bacteria and probiotics mediated by antibiotics, protein, and glucose intake. Middle: The gut microbiota‐derived amino acids, primarily through tryptophan, tyrosine, arginine, and branched‐chain amino acid pathways, regulate glioma development via mechanisms such as AHR activation, metabolic ...
Qianquan Ma, Zhihao Song, Chenlong Yang, Zijin Zhao, Guodong Tang, Jia You, Chong Zeng, Jun Yang, Qing Liu, Haoyu Li, Wei Huang   +10 more
wiley   +1 more source