CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection‐triggered encephalopathy syndromes [PDF]
Annals of Clinical and Translational Neurology, 2023 Objective Infection‐triggered encephalopathy syndromes (ITES) are potentially devastating neuroinflammatory conditions. Although some ITES syndromes have recognisable MRI neuroimaging phenotypes, there are otherwise few biomarkers of disease.
Russell C. Dale +18 more
doaj +2 more sources
Identification of kynurenine and quinolinic acid as promising serum biomarkers for drug-induced interstitial lung diseases [PDF]
Respiratory ResearchBackground Drug-induced interstitial lung disease (DILD) is a lung injury caused by various types of drugs and is a serious problem in both clinical practice and drug development.
Yuchen Sun +26 more
doaj +2 more sources
Quinolinic Acid and Nuclear Factor Erythroid 2-Related Factor 2 in Depression: Role in Neuroprogression [PDF]
Front Pharmacol, 2019 Depression is an incapacitating neuropsychiatric disorder. The serotonergic system in the brain plays an important role in the pathophysiology of depression.
Y. Bansal +4 more
semanticscholar +2 more sources
CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation [PDF]
EBioMedicine, 2023 Jingya Yan +25 more
semanticscholar +2 more sources
The Therapeutic Effect of Curcumin in Quinolinic Acid-Induced Neurotoxicity in Rats is Associated with BDNF, ERK1/2, Nrf2, and Antioxidant Enzymes [PDF]
Antioxidants (Basel), 2019 In the present study we investigated the participation of brain-derived neurotropic factor (BDNF) on the activation of the mitogen activated protein kinase (MAPK) protein extracellular signal-regulated kinase-1/2 (ERK1/2) as a mechanism of curcumin (CUR)
R. Santana-Martínez +6 more
semanticscholar +2 more sources
Intraventricular infusion of quinolinic acid impairs spatial learning and memory in young rats: a novel mechanism of lead-induced neurotoxicity [PDF]
J Neuroinflammation, 2018 Lead (Pb), a heavy metal, and quinolinic acid (QA), a metabolite of the kynurenine pathway of tryptophan metabolism, are known neurotoxicants. Both Pb and QA impair spatial learning and memory.
Abdur Rahman, M. Rao, K. Khan
semanticscholar +2 more sources
C-Reactive protein and the kynurenic acid to quinolinic acid ratio are independently associated with white matter integrity in major depressive disorder [PDF]
Brain Behav Immun, 2022 Haixia Zheng +8 more
semanticscholar +2 more sources
Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial [PDF]
Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.Abstract INTRODUCTION Elevated total homocysteine (tHcy) is a major predictor of brain atrophy, cognitive decline, and Alzheimer's disease (AD) progression. The VITACOG trial, a randomized, placebo‐controlled study in mild cognitive impairment (MCI), previously showed that B vitamin supplementation lowered tHcy, slowing brain atrophy and cognitive ...
Tereza Kacerova +15 more
wiley +2 more sources
Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina [PDF]
Invest Ophthalmol Vis Sci, 2017 Purpose We investigated the relationship between inflammation, neuronal loss, and expression of indoleamine 2, 3-dioxygenase (IDO) and quinolinic acid (QUIN) in the retina of subjects with type 1 diabetes (T1D) and type 2 diabetes (T2D) and in the retina
Ping Hu +10 more
semanticscholar +2 more sources
Crystal structure of N-[2-(cyclohexylsulfanyl)ethyl]quinolinic acid imide [PDF]
Acta Crystallographica Section E: Crystallographic Communications, 2017 The title compound, C15H18N2O2S {systematic name: 6-[2-(cyclohexylsulfanyl)ethyl]-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione}, was obtained from the reaction of pyridine-2,3-dicarboxylic anhydride (synonym: quinolinic anhydride) with 2-(cyclohexylsulfanyl ...
Hyunjin Park +3 more
doaj +2 more sources