Results 11 to 20 of about 16,555 (256)

A pro-convulsive carbamazepine metabolite: Quinolinic acid in drug resistant epileptic human brain

Neurobiology of Disease, 2012
Drugs and their metabolites often produce undesirable effects. These may be due to a number of mechanisms, including biotransformation by P450 enzymes which are not exclusively expressed by hepatocytes but also by endothelial cells in brain from ...
Chaitali Ghosh, Nicola Marchi, Mohammed Hossain, Peter Rasmussen, Andreas V. Alexopoulos, Jorge Gonzalez-Martinez, Hu Yang, Damir Janigro   +7 more
doaj   +2 more sources

Serum Kynurenine Pathway Metabolites as Candidate Diagnostic Biomarkers for Pituitary Adenoma: A Case–Control Study [PDF]

Medicina
Background and Objectives: Pituitary adenomas are common intracranial tumors lacking specific non-invasive biomarkers. This study aimed to determine whether key metabolites and enzymes of the kynurenine pathway—including indoleamine 2,3-dioxygenase (IDO),
Nur Düzen Oflas, Halil İbrahim Akbay, Murat Alay, Mehmet Erdem   +3 more
doaj   +2 more sources

Quinolinic acid impairs mitophagy promoting microglia senescence and poor healthspan in C. elegans: a mechanism of impaired aging process. [PDF]

Biol Direct, 2023
Dongol A, Chen X, Zheng P, Seyhan ZB, Huang XF.   +4 more
europepmc   +3 more sources

Plumbagin Alleviates Intracerebroventricular-Quinolinic Acid Induced Depression-like Behavior and Memory Deficits in Wistar Rats. [PDF]

Molecules, 2022
Kumar Arora M, Ratra A, Asdaq SMB, Alshamrani AA, Alsalman AJ, Kamal M, Tomar R, Sahoo J, Ashok J, Imran M.   +9 more
europepmc   +3 more sources

QUINOLINIC ACID METABOLISM

Journal of Biological Chemistry, 1949
L.M. Henderson, G.B. Ramasarma
  +6 more sources

Crystal structure of N-[2-(cyclohexylsulfanyl)ethyl]quinolinic acid imide [PDF]

Acta Crystallographica Section E: Crystallographic Communications, 2017
The title compound, C15H18N2O2S {systematic name: 6-[2-(cyclohexylsulfanyl)ethyl]-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione}, was obtained from the reaction of pyridine-2,3-dicarboxylic anhydride (synonym: quinolinic anhydride) with 2-(cyclohexylsulfanyl ...
Hyunjin Park, Myong Yong Choi, Cheol Joo Moon, Tae Ho Kim   +3 more
doaj   +2 more sources

Adduct formed by chromium trioxide and zwitterionic quinolinic acid [PDF]

Open Chemistry, 2010
Sundberg Markku, Uggla Rolf, Sillanpää Reijo, Zborowski Krzysztof, Sánchez-González Angel, Matikainen Jorma, Kaltia Seppo, Hase Tapio   +7 more
doaj   +2 more sources

Quinolinic acid and glutamatergic neurodegeneration in Caenorhabditis elegans. [PDF]

Neurotoxicology, 2018
da Silveira TL, Zamberlan DC, Arantes LP, Machado ML, da Silva TC, Câmara DF, Santamaría A, Aschner M, Soares FAA.   +8 more
europepmc   +3 more sources

Baseline multi‐omics signatures could predict therapeutic response to neoadjuvant anti‐PD‐1 immunochemotherapy in non‐small‐cell lung cancer

Clinical and Translational Medicine
Background Neoadjuvant anti‐programmed cell death 1 (PD‐1) immunochemotherapy has shown promising efficiency in the treatment of early‐stage non‐small‐cell lung cancer (NSCLC), but it has not consistently yielded durable responses.
Ailing Cao, Yaobin Lin, Shaoxing Guan, Youhao Chen, Wenyu Zhai, Yuheng Zhou, Shoucheng Feng, Yanping Guan, Yiyu Zhang, Min Huang, Xueding Wang, Hao Long   +11 more
doaj   +2 more sources

Editorial Note: The excitotoxin quinolinic acid induces tau phosphorylation in human neurons. [PDF]

PLoS One
PLOS One Editors.
europepmc   +3 more sources