Molecules, 2022 The scavenging activity of hydroxyl radicals, produced by the Fenton reaction, is commonly used to quantify the antioxidant capacity of plant extracts. In this study, three Fenton systems (Fe/phosphate buffer, Fe/quinolinic acid and Fe/phosphate buffer ...
Daniele Sanna, Angela Fadda
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Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome
Frontiers in Endocrinology, 2022 BackgroundWomen with polycystic ovary syndrome (PCOS) suffer from dysfunctional metabolism and studies have reported increased levels of tryptophan in patients with PCOS.
Siyu Wang +25 more
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Synthesis of some new substituted imines from aldehydes and ketones derived from quinolinic acid
Eclética Química, 2023 In this paper, some substituted imines compounds have been prepared from quinolinic acid as a starting material. Firstly, the quinolinic acid was treated with acetic anhydride and acetic acid to form furo[3,4-b]pyridine-5,7-dione (1); the resulting ...
Anwar Abdulghani Fathi +2 more
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HIV, prospective memory, and cerebrospinal fluid concentrations of quinolinic acid and phosphorylated Tau. [PDF]
J Neuroimmunol, 2018 Anderson AM +8 more
europepmc +3 more sources
Transplantation of induced pluripotent stem cells improves functional recovery in Huntington's disease rat model. [PDF]
PLoS ONE, 2014 The purpose of this study was to determine the functional recovery of the transplanted induced pluripotent stem cells in a rat model of Huntington's disease with use of 18F-FDG microPET/CT imaging.In a quinolinic acid-induced rat model of striatal ...
Shuhua Mu +8 more
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“Kynurenine switch” and obesity
Бюллетень сибирской медицины, 2022 Aim. To assess the concentrations of bacterial and eukaryotic metabolites mainly involved in indole, kynurenine, and serotonin pathways of tryptophan metabolism in a cohort of patients with obesity. Materials and methods.
A. V. Shestopalov +9 more
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Quinolinic Acid: Neurotoxin or Oxidative Stress Modulator? [PDF]
International Journal of Molecular Sciences, 2013 Quinolinic acid (2,3-pyridinedicarboxylic acid, QUIN) is a well-known neurotoxin. Consequently, QUIN could produce reactive oxygen species (ROS). ROS are generated in reactions catalyzed by transition metals, especially iron (Fe). QUIN can form coordination complexes with iron.
Lenka Kubicova +2 more
openaire +5 more sources
Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]
, 2010 Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
Berfelo, M. W. +6 more
core +5 more sources
M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. [PDF]
PLoS ONE, 2012 Indoleamine 2,3-dioxygenesae-1 (IDO-1) catalyses the initial, rate-limiting step in tryptophan metabolism, thereby regulating tryptophan availability and the formation of downstream metabolites, including picolinic and quinolinic acid.
Antje Blumenthal +8 more
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