Quinolinic acid, the inescapable neurotoxin [PDF]
The FEBS Journal, 2012 Over the last two decades, evidence for the involvement of quinolinic acid (QUIN) in neuroinflammatory diseases has been exponentially increasing. Within the brain, QUIN is produced and released by infiltrating macrophages and activated microglia, the very cells that are prominent during neuroinflammation.
Gilles J. Guillemin, Gilles J. Guillemin
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Transplantation of induced pluripotent stem cells improves functional recovery in Huntington's disease rat model. [PDF]
PLoS ONE, 2014 The purpose of this study was to determine the functional recovery of the transplanted induced pluripotent stem cells in a rat model of Huntington's disease with use of 18F-FDG microPET/CT imaging.In a quinolinic acid-induced rat model of striatal ...
Shuhua Mu +8 more
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“Kynurenine switch” and obesity
Бюллетень сибирской медицины, 2022 Aim. To assess the concentrations of bacterial and eukaryotic metabolites mainly involved in indole, kynurenine, and serotonin pathways of tryptophan metabolism in a cohort of patients with obesity. Materials and methods.
A. V. Shestopalov +9 more
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Quinolinic Acid: Neurotoxin or Oxidative Stress Modulator? [PDF]
International Journal of Molecular Sciences, 2013 Quinolinic acid (2,3-pyridinedicarboxylic acid, QUIN) is a well-known neurotoxin. Consequently, QUIN could produce reactive oxygen species (ROS). ROS are generated in reactions catalyzed by transition metals, especially iron (Fe). QUIN can form coordination complexes with iron.
Lenka Kubicova +2 more
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M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. [PDF]
PLoS ONE, 2012 Indoleamine 2,3-dioxygenesae-1 (IDO-1) catalyses the initial, rate-limiting step in tryptophan metabolism, thereby regulating tryptophan availability and the formation of downstream metabolites, including picolinic and quinolinic acid.
Antje Blumenthal +8 more
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Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]
, 2010 Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
Berfelo, M. W. +6 more
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Definitions, 2020 An intermediate product of the kynurenine pathway, which is responsible for the conversion of the amino acid tryptophan into nicotinamide adenine dinucleotide, with potential neurotoxic activity. If produced in excess, quinolinic acid can cross the blood-
J. L. McBride, S. Ramaswamy, J. Kordower
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The role of the kynurenine pathway and quinolinic acid in adolescent major depressive disorder
International journal of clinical practice, 2020 The biological mechanisms underlying major depressive disorder (MDD) are not yet sufficiently understood. The kynurenine pathway has been proposed to play a key role between peripheral inflammation and alterations in the central nervous system.
Masum Öztürk +4 more
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Hesperidin Plays Neuroprotective Effects Against Quinolinic Acid in Human SH-SY5Y Cells: Focusing on ROS Levels and Cell Cycle Arrest [PDF]
Research Journal of PharmacognosyBackground and objectives: In some neurodegenerative diseases, an aberrant accumulation of quinolinic acid is frequently associated with the loss of nerve cells and a condition known as neuritis.
Farzaneh Abbasinezhad-Moud +4 more
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The kynurenine pathway and the brain: challenges, controversies and promises [PDF]
, 2017 Research on the neurobiology of the kynurenine pathway has suffered years of relative obscurity because tryptophan degradation, and its involvement in both physiology and major brain diseases, was viewed almost exclusively through the lens of the well ...
Schwarcz, Robert, Stone, Trevor W.
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