Results 51 to 60 of about 9,006 (217)

Action of Amines on Quinolinic Acid.

, 1934
Action of Amines on Quinolinic Acid.
ANANDA KISHORE DAS, LNDU BHUSON BARKER
openaire   +1 more source

Chemistry, Applications, and Synthesis Methods of Indole Derivatives: A Comprehensive Review

The Chemical Record, EarlyView.
Indole and its derivatives represent a vital class of heterocycles with broad applications in pharmaceuticals, agrochemicals, and materials science. This review explores their applications, biosynthesis, key derivatives such as tryptophan, and presents an overview of both classical and modern synthetic methodologies, with a focus on sustainable ...
Raphael Silva Moratório de Moraes, Ana Beatriz Mestre Botelho, Gabriel Tavares de Almeida Pinto, Searitha Couto Rodrigues, Maria Tereza Miranda Martins, Deivid Lucas Alves Soares, Camille Cardoso Cruz, Aline de Almeida Pinto, Flaviana Rodrigues Fintelman Dias, Patricia Dias Fernandes, Anna Claudia Cunha   +10 more
wiley   +1 more source

Kynurenines link chronic inflammation to functional decline and physical frailty

JCI Insight, 2020
Chronic inflammation is associated with physical frailty and functional decline in older adults; however, the molecular mechanisms of this linkage are not understood.
Reyhan Westbrook, Tae Chung, Jacqueline Lovett, Chris Ward, Humberto Joca, Huanle Yang, Mohammed Khadeer, Jing Tian, Qian-Li Xue, Anne Le, Luigi Ferrucci, Ruin Moaddel, Rafa de Cabo, Ahmet Hoke, Jeremy Walston, Peter M. Abadir   +15 more
doaj   +1 more source

Kynurenine pathway metabolites selectively associate with impaired associative memory function in depression

Brain, Behavior, & Immunity - Health, 2020
Activation of the kynurenine pathway (KP), an important downstream effect of inflammation, is a driver of depression and neurodegeneration. Damage from the end product of KP activation, quinolinic acid, may be responsible specifically for impairment in ...
Margherita Chirico, James Custer, Ifeoluwa Shoyombo, Crystal Cooper, Sheila Meldrum, Robert Dantzer, Madhukar H. Trivedi, Paul Rathouz, Marisa S. Toups   +8 more
doaj   +1 more source

Tryptophan derivatives as non‐invasive diagnostic indicators for obesity‐related MASLD in children and adolescents

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) represents a major health burden in children and adolescents with obesity. This study aimed to characterize metabolic alterations associated with obesity‐related MASLD and to evaluate the potential of tryptophan (TRP)‐derived metabolites as non‐invasive biomarkers for early ...
Shumin Zhan, Xingyun Wang, Chen Wang, Bowen Zhu, Jianfang Gao, Zhou Peng, Rui Wang, Yun Yang, Liang Zhang, Tengfei Wang, Jiaoxiang Wu, Wei Wu, Ke Huang, Guanping Dong, Qiannan Ren, Shan Wang, Senjie Wang, Xuelian Zhou, Liling Xu, Junfen Fu, Xirong Guo   +20 more
wiley   +1 more source

Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: Role in excitotoxicity

Neurobiology of Disease, 2009
Calcineurin is a serine/threonine phosphatase involved in the regulation of glutamate receptors signaling. Here, we analyzed whether the regulation of calcineurin protein levels and activity modulates the susceptibility of striatal neurons to ...
Xavier Xifró, Albert Giralt, Ana Saavedra, Juan M. García-Martínez, Miguel Díaz-Hernández, José J. Lucas, Jordi Alberch, Esther Pérez-Navarro   +7 more
doaj   +1 more source

Effect of a Single Bout of Aerobic Exercise on Kynurenine Pathway Metabolites and Inflammatory Markers in Prostate Cancer Patients—A Pilot Randomized Controlled Trial

Metabolites, 2020
The kynurenine (KYN) pathway gains growing research interest concerning the genesis, progression and therapy of solid tumors. Previous studies showed exercise-induced effects on metabolite levels along the KYN pathway.
Alexander Schenk, Tobias Esser, André Knoop, Mario Thevis, Jan Herden, Axel Heidenreich, Wilhelm Bloch, Niklas Joisten, Philipp Zimmer   +8 more
doaj   +1 more source

Exercise‐induced effects on atherogenesis and tryptophan catabolism via the kynurenine pathway in an HIV‐associated atherosclerosis mouse model

Experimental Physiology, EarlyView.
Abstract A mouse model of HIV‐associated atherosclerosis (Tg26+/−ApoE−/−) exhibited increased plaque area compared with the ApoE−/− mouse, linked to elevated indoleamine 2,3‐dioxygenase (IDO) activity. IDO catalyses the conversion of tryptophan (TRP) into kynurenine (KYN), measured by the KYN‐to‐TRP ratio.
Marcus V. S. Rangel, Mohammad Afaque Alam, Mohammad Islamuddin, Zheng Chen, Xuebin Qin, Juliana P. Borges   +5 more
wiley   +1 more source

4-Chlorobenzoic acid–quinoline (1/1) [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
In the title compound, C(7)H(5)ClO(2)·C(9)H(7)N, the 4-chloro-benzoic acid mol-ecule is almost planar, with a dihedral angle of 2.9 (14)° between the carb-oxy group and the benzene ring. In the crystal, the two components are connected by an O-H⋯N hydrogen bond.
Kaori Katagiri, Kazuma Gotoh, Hiroyuki Ishida   +2 more
openaire   +3 more sources

Advances in epilepsy associated with 16p11.2 microdeletion syndrome

Clinical and Translational Discovery, Volume 5, Issue 5, October 2025.
This comprehensive review explores the evolving understanding of epilepsy related to 16p11.2 microdeletion syndrome, highlighting both clinical manifestations and cutting‐edge mechanistic research. We focus in particular on five key genes—PRRT2, KCTD13, TAOK2, QPRT and SEZ6L2.
Qikai Zhao, Shuqi Liang, Xiao Wu, Xiaohui Min, Nooraynee Bibi Needah Ginowree, Gang Zhang   +5 more
wiley   +1 more source