Results 61 to 70 of about 16,555 (256)

Age-related increase of kynurenic acid in human cerebrospinal fluid-IgG and beta(2)-microglobulin changes [PDF]

, 2005
Kynurenic acid (KYNA) is an endogenous metabolite in the kynurenine pathway of tryptophan degradation and is an antagonist at the glycine site of the N-methyl-D-aspartate as well as at the alpha 7 nicotinic cholinergic receptors. In the brain tissue KYNA
Baran, H, Ferraz-Leite, H, Kainz, A, Kalina, P, Kepplinger, B, Newcombe, J   +5 more
core  

In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning [PDF]

, 2014
A key transducer in energy conservation and signaling cell death is the mitochondrial H+-ATP synthase. The expression of the ATPase inhibitory factor 1 (IF1) is a strategy used by cancer cells to inhibit the activity of the H+-ATP synthase to generate a ...
Cuezva, José M., Formentini, Laura, Lucas, José J., Martínez-Serrano, Alberto, Navarro, Carmen, Pereira, Marta P., Santacatterina, Fulvio, Sánchez-Cenizo, Laura   +7 more
core   +3 more sources

Phocaeicola coprophilus‐Derived 6‐Methyluracil Attenuates Radiation‐Induced Intestinal Fibrosis by Suppressing the IDO1‐Kynurenine‐AHR Axis

Advanced Science, EarlyView.
IR‐induced dysbiosis depletes P. coprophilus and its metabolite 6‐methyluracil, leading to disinhibition of the IDO1‐Kyn‐AHR axis. This results in sustained fibroblast activation and collagen deposition, driving radiation induced intestinal fibrosis. ABSTRACT Therapeutic options for radiation‐induced intestinal fibrosis (RIF) remain limited. This study
Jiaxin Zhang, Zhen Wang, Shuang Li, Chao Luo, Han Li, Shengjie Ma, Pai Wang, Heshi Liu, Lijun Sun, Yue Yin, Weizhen Zhang, Quan Wang   +11 more
wiley   +1 more source

Development of a translational inflammation panel for the quantification of cerebrospinal fluid Pterin, Tryptophan-Kynurenine and Nitric oxide pathway metabolites

EBioMedicine, 2022
Summary: Background: Neuroinflammatory diseases such as encephalitis, meningitis, multiple sclerosis and other neurological diseases with inflammatory components, have demonstrated a need for diagnostic biomarkers to define treatable and reversible ...
Jingya Yan, Velda X. Han, Benjamin Heng, Gilles J. Guillemin, Sushil Bandodkar, Russell C. Dale   +5 more
doaj   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

The Isotropic Fractionator as a Tool for Quantitative Analysis in Central Nervous System Diseases [PDF]

, 2016
One major aim in quantitative and translational neuroscience is to achieve a precise and fast neuronal counting method to work on high throughput scale to obtain reliable results.Here we tested the Isotropic Fractionator (IF) method for evaluating ...
Alessandro Vercelli, Alessia Arbini, Carlos-Humberto Andrade-Moraes, Ivan E. Repetto, Marta Tropiano, Riccardo Monti, Roberto Lent, Simone Tomasi   +7 more
core   +2 more sources

Vitamin C and E Treatment Blocks Changes in Kynurenine Metabolism Triggered by Three Weeks of Sprint Interval Training in Recreationally Active Elderly Humans

Antioxidants, 2021
The kynurenine pathway (KP) is gaining attention in several clinical fields. Recent studies show that physical exercise offers a therapeutic way to improve ratios of neurotoxic to neuroprotective KP metabolites.
Victoria L. Wyckelsma, Ada Trepci, Lilly Schwieler, Tomas Venckunas, Marius Brazaitis, Sigitas Kamandulis, Henrikas Paulauskas, Helena Gapeyeva, Mati Pääsuke, Stefano Gastaldello, Sophie Imbeault, Håkan Westerblad, Sophie Erhardt, Daniel C. Andersson   +13 more
doaj   +1 more source

In vivo evidence for NMDA receptor mediated excitotoxicity in a murine genetic model of Huntington Disease [PDF]

, 2008
N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien, Mary Heng, Peter Detloff, Phillip Wang, Roger Albin   +4 more
core   +1 more source

Metabolomics variable selection and classification in the presence of observations below the detection limit using an extension of ERp [PDF]

, 2017
A compressed folder (XERp Software.zip) containing the Matlab scripts to perform XERp as well as an example application.
Carolus J. Reinecke, J Hendrik Venter, Johan A. Westerhuis, Mari van Reenen   +3 more
core   +4 more sources