Results 81 to 90 of about 16,454 (258)

Can IDO activity predict primary resistance to anti-PD-1 treatment in NSCLC?

Journal of Translational Medicine, 2018
Background Immune checkpoint inhibitors have revolutionized the treatment paradigm of highly lethal malignancies like advanced non-small cell lung cancer (NSCLC), demonstrating long-term tumour control and extended patient survival.
Andrea Botticelli, Bruna Cerbelli, Luana Lionetto, Ilaria Zizzari, Massimiliano Salati, Annalinda Pisano, Mazzuca Federica, Maurizio Simmaco, Marianna Nuti, Paolo Marchetti   +9 more
doaj   +1 more source

Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition

Frontiers in Molecular Biosciences, 2019
The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metabolites in the kynurenine pathway, however, are potentially toxic, particularly 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid ...
Robert S. Phillips, Robert S. Phillips, Emma Carine Iradukunda, Tamera Hughes, J. Phillip Bowen   +4 more
doaj   +1 more source

Quinoline-2-carbonitrile–fumaric acid (1/0.5) [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
تتكون الوحدة غير المتماثلة لمركب العنوان، C(10)H(6)N(2)·0.5C(4)H(4)O(4)، من مول- إيكول واحد من الكينولين-2 -كاربونيتريل ونصف مول- إيكول من حمض الفوماريك، الذي يقع على مركز الانقلاب. تكون جزيئات الكينولين-2 - كاربونيتريل مستوية تقريبًا، مع انحراف قدره 0.008 (1) Å. يرتبط الحمض والقاعدة معًا عبر أزواج من الروابط الهيدروجينية C - H½O و O - H½N بين الجزيئات،
Wan-Sin Loh, Ching Kheng Quah, Madhukar Hemamalini, Hoong‐Kun Fun   +3 more
openaire   +2 more sources

Acute Psychological Stress Modulates the Expression of Enzymes Involved in the Kynurenine Pathway throughout Corticolimbic Circuits in Adult Male Rats

Neural Plasticity, 2016
Tryptophan is an essential dietary amino acid that is necessary for protein synthesis, but also serves as the precursor for serotonin. However, in addition to these biological functions, tryptophan also serves as a precursor for the kynurenine pathway ...
Haley A. Vecchiarelli, Chaitanya P. Gandhi, Matthew N. Hill   +2 more
doaj   +1 more source

Kynurenine Pathway in Psoriasis—a Promising Link?

Dermatology and Therapy, 2023
Psoriasis is a common dermatosis which affects the patient’s skin and general well-being because of its link to diseases such as depression, kidney disease and metabolic syndrome.
A. Stepaniuk, A. Baran, I. Flisiak
doaj   +1 more source

Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology [PDF]

, 2015
Mounting evidence demonstrates that kynurenine metabolism may play an important pathogenic role in the development of multiple neurological and neuropsychiatric disorders.
Jason C. O’Connor, Jennifer M. Parrott
core   +2 more sources

The Gut Microbiota–Insulin Resistance Axis: Mechanisms, Clinical Implications, and Therapeutic Potential

FASEB BioAdvances, Volume 8, Issue 1, January 2026.
Dysbiosis‐induced alterations in microbial metabolite production promote intestinal barrier disruption and systemic inflammation, driving insulin resistance and metabolic dysfunction. Microbiota‐targeting therapies represent promising approaches to restore host metabolic health.
Mohamad Al Qassab, Nadim Chaarani, Amira Hamou, Rasha Harb, Ahmad Jradi, Mira Zeineddine, Hilda E. Ghadieh, Ziad Abi Khattar, Sami Azar, Amjad Kanaan, Frederic Harb   +10 more
wiley   +1 more source

M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus [PDF]

, 2016
Monoamine oxidases (MAO), downstream targets of glucocorticoid, maintain the turnover and homeostasis of monoamine neurotransmitters; yet, its pathophysiological role in monoamine deficiency, oxidative stress and neuroinflammation remains controversial ...
Fung, ML, LAM, CS, Tipoe, GL, Wong, KC, Youdim, MBH   +4 more
core   +1 more source

Design, Optimized Synthesis, and Coordination Behavior of Quinolinic Benzimidazoles with Cu(II) and Ni(II): Reactivity Toward ROS, Computational Studies, and Biological Profiling

European Journal of Inorganic Chemistry, Volume 28, Issue 35, December 9, 2025.
Synthesis and characterization of quinolinic benzimidazole Cu(II) and Ni(II) complexes reveal contrasting reactive oxygen species interactions and selective anticancer activity, highlighting a prodrug‐like mechanism. This study provides new insights into designing redox‐active metal complexes for targeted cancer therapeutics Benzimidazole is a well ...
Lorenzo Verderi, Silvana Pinelli, Giorgio Pelosi, Franco Bisceglie   +3 more
wiley   +1 more source

Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease

Journal of Neuroinflammation, 2019
Background Blood markers indicative of neurodegeneration (neurofilament light chain; NFL), Alzheimer’s disease amyloid pathology (amyloid-β; Aβ), and neuroinflammation (kynurenine pathway; KP metabolites) have been investigated independently in ...
Pratishtha Chatterjee, Henrik Zetterberg, Kathryn Goozee, Chai K. Lim, Kelly R. Jacobs, Nicholas J. Ashton, Abdul Hye, Steve Pedrini, Hamid R. Sohrabi, Tejal Shah, Prita R. Asih, Preeti Dave, Kaikai Shen, Kevin Taddei, David B. Lovejoy, Gilles J. Guillemin, Kaj Blennow, Ralph N. Martins   +17 more
doaj   +1 more source