Results 81 to 90 of about 16,555 (256)

Exercise‐induced effects on atherogenesis and tryptophan catabolism via the kynurenine pathway in an HIV‐associated atherosclerosis mouse model

Experimental Physiology, EarlyView.
Abstract A mouse model of HIV‐associated atherosclerosis (Tg26+/−ApoE−/−) exhibited increased plaque area compared with the ApoE−/− mouse, linked to elevated indoleamine 2,3‐dioxygenase (IDO) activity. IDO catalyses the conversion of tryptophan (TRP) into kynurenine (KYN), measured by the KYN‐to‐TRP ratio.
Marcus V. S. Rangel, Mohammad Afaque Alam, Mohammad Islamuddin, Zheng Chen, Xuebin Qin, Juliana P. Borges   +5 more
wiley   +1 more source

Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition

Frontiers in Molecular Biosciences, 2019
The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metabolites in the kynurenine pathway, however, are potentially toxic, particularly 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid ...
Robert S. Phillips, Robert S. Phillips, Emma Carine Iradukunda, Tamera Hughes, J. Phillip Bowen   +4 more
doaj   +1 more source

The Crohn's Disease Exclusion Diet Across the Lifespan, Indications and the Globe: An Expert Review Towards Personalized Therapy in Crohn's Disease

JCC Plus, Volume 1, Issue 2, March 2026.
ABSTRACT Background and Aims The Crohn's disease (CD) exclusion diet (CDED) is an established treatment for active CD with a growing body of evidence supporting its use across diverse populations and disease phenotypes. Particularly effective in mild‐to‐moderate cases, CDED is recognized by clinical guidelines including ESPEN, AGA and ECCO nutritional ...
Rotem Sigall Boneh, Elena Banci, Luca Scarallo, Marta Herrador‐López, Emma P. Halmos, Dror S. Shouval, Nicolette Wierdsma, Chen Sarbagili‐Shabat, Víctor Manuel Navas‐López, Javier Martín‐de‐Carpi, Yulia Ron, Lindsey Albenberg, Henit Yanai, Franck Carbonnel, Johan Van Limbergen, Nitsan Maharshak, Paolo Lionetti, Eytan Wine   +17 more
wiley   +1 more source

The kynurenine pathway: towards metabolic equilibrium [PDF]

, 2016
No abstract ...
Clarke, Gerard, Schwarcz, Robert, Stone, Trevor W.   +2 more
core   +2 more sources

Quinoline-2-carbonitrile–fumaric acid (1/0.5) [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
تتكون الوحدة غير المتماثلة لمركب العنوان، C(10)H(6)N(2)·0.5C(4)H(4)O(4)، من مول- إيكول واحد من الكينولين-2 -كاربونيتريل ونصف مول- إيكول من حمض الفوماريك، الذي يقع على مركز الانقلاب. تكون جزيئات الكينولين-2 - كاربونيتريل مستوية تقريبًا، مع انحراف قدره 0.008 (1) Å. يرتبط الحمض والقاعدة معًا عبر أزواج من الروابط الهيدروجينية C - H½O و O - H½N بين الجزيئات،
Wan-Sin Loh, Ching Kheng Quah, Madhukar Hemamalini, Hoong‐Kun Fun   +3 more
openaire   +2 more sources

Elevating Circulating L‐Kynurenine Promotes Frailty in Aging Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background L‐Kynurenine (L‐Kyn), a product of tryptophan catabolism, increases with age and has been associated with reduced physical function and increased frailty in humans. Robustly expressed in skeletal muscle, kynurenine aminotransferases (KATs) degrade L‐Kyn into kynurenic acid and are regulated by the transcriptional co‐regulator ...
Mia Y. Kawaida, Abigail L. Tice, Samuel Alvarez, Jacob A. Lackey, Benjamin Izaguirre, Qingping Yang, Lan Wei‐LaPierre, Russell T. Hepple, Terence E. Ryan   +8 more
wiley   +1 more source

Acute Psychological Stress Modulates the Expression of Enzymes Involved in the Kynurenine Pathway throughout Corticolimbic Circuits in Adult Male Rats

Neural Plasticity, 2016
Tryptophan is an essential dietary amino acid that is necessary for protein synthesis, but also serves as the precursor for serotonin. However, in addition to these biological functions, tryptophan also serves as a precursor for the kynurenine pathway ...
Haley A. Vecchiarelli, Chaitanya P. Gandhi, Matthew N. Hill   +2 more
doaj   +1 more source

Can IDO activity predict primary resistance to anti-PD-1 treatment in NSCLC?

Journal of Translational Medicine, 2018
Background Immune checkpoint inhibitors have revolutionized the treatment paradigm of highly lethal malignancies like advanced non-small cell lung cancer (NSCLC), demonstrating long-term tumour control and extended patient survival.
Andrea Botticelli, Bruna Cerbelli, Luana Lionetto, Ilaria Zizzari, Massimiliano Salati, Annalinda Pisano, Mazzuca Federica, Maurizio Simmaco, Marianna Nuti, Paolo Marchetti   +9 more
doaj   +1 more source

Kynurenine Pathway in Psoriasis—a Promising Link?

Dermatology and Therapy, 2023
Psoriasis is a common dermatosis which affects the patient’s skin and general well-being because of its link to diseases such as depression, kidney disease and metabolic syndrome.
A. Stepaniuk, A. Baran, I. Flisiak
doaj   +1 more source

TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria [PDF]

, 2016
The 18-kDa translocator protein (TSPO) localizes in the outer mitochondrial membrane (OMM) of cells and is readily up-regulated under various pathological conditions such as cancer, inflammation, mechanical lesions and neurological diseases. Able to bind
Aghazadeh, Aghazadeh, Alho, Amitani, Anholt, Anholt, Anholt, Anholt, Antkiewicz-Michaluk, Arbo, Banati, Banati, Bar-Ami, Barron, Basile, Batarseh, Batarseh, Batarseh, Batarseh, Batra, Beinlich, Benavides, Bernassau, Besman, Bird, Bitran, Bose, Boujrad, Boujrad, Braestrup, Bribes, Bribes, Brunette, Cagnin, Campanella, Campioli, Casellas, Chauveau, Chen, Chen, Cho, Clark, Colasanti, Corcia, Costa, Costa, Costa, Cuhlmann, Daugherty, De Souza, Decaudin, Decker, Delavoie, Delerive, Doperalski, Enders, Epstein, Fafalios, Fan, Fan, Fan, Fur, Fur, Galiegue, Gastaldello, Gatliff, Gatliff, Gavish, Gavish, Gazouli, Gehlert, Gerhard, Gervois, Giatti, Giatzakis, Giatzakis, Golani, Gonzalez-Polo, Guillon, Gulyas, Guo, Guo, Gut, Hardwick, Hardwick, Hauet, Hauet, Jamin, Jaremko, Jaremko, Jemma Gatliff, Joo, Joseph-Liauzun, Karlstetter, Kita, Kondo, Konigsrainer, Korkhov, Kreisl, Kruczek, Kumar, Lacapere, Lacapere, Lavisse, Li, Li, Li, Li, Li, Li, Libby, Liu, Liu, Maia, Maury, Mazurika, McEnery, Miao, Michelangelo Campanella, Midzak, Midzak, Miettinen, Miller, Mills, Mizrahi, Morohaku, Murail, Nagler, Obame, Oberto, Olson, Ostuni, Ouchi, Owen, Owen, Owen, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Paradis, Pastorino, Pelechano, Petrescu, Poynter, Raghavan, Rey, Romeo, Rone, Rosenberg, Rosenberg, Rosenberg, Rupprecht, Rupprecht, Scarf, Schaller, Selvaraj, Shoukrun, Sileikyte, Soustiel, Sutter, Tang, Taylor, Teboul, Thompson, Trincavelli, Tu, Tu, Tu, Vanhee, Varrone, Vega, Verma, Wang, Wang, Wei, Whalin, Xiao, Yang, Yang, Yasuno, Yeliseev, Yoder, Zhang, Zhang, Zhao, Zhou   +189 more
core   +1 more source