Results 61 to 70 of about 3,612 (183)

Fused-Ring Derivatives of Quinoxalines: Spectroscopic Characterization and Photoinduced Processes Investigated by EPR Spin Trapping Technique

Molecules, 2014
10-Ethyl-7-oxo-7,10-dihydropyrido[2,3-f]quinoxaline derivatives, synthesized as promising biologically/photobiologically active compounds were characterized by UV/vis, FT-IR and fluorescent spectroscopy.
Zuzana Barbieriková, Dana Dvoranová, Maroš Bella, Viktor Milata, Adriana Czímerová, Vlasta Brezová   +5 more
doaj   +1 more source

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source

A Comparative Analysis of Maillard‐Derived α‐Dicarbonyl Compounds and Advanced Glycation End Products in Fresh, Wet, Kibble, and Freeze‐Dried Dog Foods

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Thermal processing of pet foods can lead to the formation of harmful Maillard reaction products (MRPs), which may compromise nutritional quality and pose health risks to companion animals. This study compared the levels of MRPs in 41 commercial dog foods, including fresh (n = 15), kibble (n = 13), wet (n = 10), freeze‐dried (n = 2), and cold ...
Tolgahan Kocadağlı, Ciara Clarke, Vural Gökmen   +2 more
wiley   +1 more source

An insight into the therapeutic impact of quinoxaline derivatives: Recent advances in biological activities (2020–2024)

Results in Chemistry
Quinoxaline derivatives have garnered significant attention due to their wide-ranging therapeutic applications. Research from 2020 to 2024 has demonstrated their potent bioactivity across various domains, including anticancer, antimicrobial, antiviral ...
Aly M. Waseem, Ranya Mohammed Elmagzoub, Mervat Mohammed Mazhar Abdelgadir, Areej Al Bahir, N.S. Abd EL-Gawaad, Ahmed S. Abdel-Samea, Devendra Pratap Rao, Konstantinos Kossenas, Stefan Bräse, Hamada Hashem   +9 more
doaj   +1 more source

Divergent Access to Fluorinated Pharmacons From Ethyl Trifluoropyruvate

Advanced Synthesis &Catalysis, Volume 368, Issue 7, 1 April 2026.
Fluoro(oxo) functional group diversification is traditionally accomplished through either specialized reagents or nucleophilic trifluoromethylation. Herein is disclosed the use of commercially available building blocks for the synthesis of trifluoromethyl(hydroxy) esters.
Rifat N. Nabi, Ryan C. Kashatus, Kaden M. Joseph, Salina Zhang, Daniel K. Kim   +4 more
wiley   +1 more source

Quinoxaline 1,4-di-N-oxide Derivatives as New Antinocardial Agents

Molecules
Mycetoma is currently considered as a neglected tropical disease. The incidence of mycetoma is unknown but most of the worldwide cases are present in the “mycetoma belt” including countries like Mexico, India, Senegal, and others.
Isidro Palos, Alonzo González-González, Alma D. Paz-González, José C. Espinoza-Hicks, Debasish Bandyopadhyay, Norma Paniagua-Castro, Marlene S. Galeana-Salazar, Jorge Ismael Castañeda-Sánchez, Julieta Luna-Herrera, Gildardo Rivera   +9 more
doaj   +1 more source

One-pot three-component synthesis of quinoxaline and phenazine ring systems using Fischer carbene complexes

Beilstein Journal of Organic Chemistry, 2010
One-pot three-component coupling of o-alkynylheteroaryl carbonyl derivatives with Fischer carbene complexes and dienophiles leading to the synthesis of quinoxaline and phenazine ring systems has been investigated. This involves the generation of furo[3,4-
Priyabrata Roy, Binay Krishna Ghorai
doaj   +1 more source

Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley   +1 more source

Solution‐Processed Organic Photovoltaics: Fabrication Advances and Challenges

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review highlights recent advances in organic photovoltaic (OPV) device fabrication, emphasizing how material selection, interface engineering, and scalable processing techniques shape device performance. It discusses progress in photoactive and charge transport layers, electrode optimization, and large‐area manufacturing, offering insights into ...
Kerui Liu, Chenyujie Zhu, Yuanyuan Jiang, Feng Liu, Xiaozhang Zhu   +4 more
wiley   +1 more source

Comparative Analysis of Intermediate and Advanced Maillard Reaction Products in Three Types of Commercial Edible Mushroom Products

Food Frontiers, Volume 7, Issue 2, March 2026.
ABSTRACT In recent years, rising consumption of mushroom‐based foods has highlighted concerns over the formation of harmful Maillard reaction products (HMRPs) during thermal processing. However, limited information is available on the occurrence of intermediate and advanced HMRPs, such as α‐dicarbonyl compounds (α‐DCs) and advanced glycation end ...
Yong Li, Hua Li, Jialu Yan, Zhengli Wang, Jingyu Liu, Junlong Meng, Fatih Oz, Jie Chen, Maomao Zeng, Cuiping Feng   +9 more
wiley   +1 more source