Results 101 to 110 of about 25,588 (204)

Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour [PDF]

, 2016
The five-subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in
Insall, Robert H., Machesky, Laura M., Spence, Heather J., Strathdee, Douglas, Tyrrell, Benjamin J., Woodham, Emma F.   +5 more
core   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing. [PDF]

, 2015
Deposition of potentially neurotoxic Aβ fragments derived from amyloid precursor protein (APP) at synapses may be a key contributor to Alzheimer's disease.
Goldstein, Lawrence SB, Niederst, Emily D, Reyna, Sol M   +2 more
core   +1 more source

Expression profile of Rab5, Rab7, tryptophan aspartate-containing coat protein, leprae lipoarabinomannan, and phenolic glycolipid-1 on the failure of the phagolysosome process in macrophages of leprosy patients as a viability marker of Mycobacterium leprae

International Journal of Mycobacteriology, 2016
Objective/Background: Phagolysosome process in macrophage of leprosy patients' is important in the early phase of eliminating Mycobacterium leprae invasion.
Cita Rosita Sigit Prakoeswa, Ratna Wahyuni, Iswahyudi, Dinar Adriaty, Irawan Yusuf, Sutjipto, Indropo Agusni, Shinzo Izumi   +7 more
doaj   +1 more source

The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways

Biochemistry Research International, 2020
Ras analog in brain (Rab) proteins are small guanosine triphosphatases (GTPases) that belong to the Ras-like GTPase superfamily, and they can regulate vesicle trafficking.
Wanqiong Yuan, Chunli Song
doaj   +1 more source

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion [PDF]

, 2013
Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites
A Fomovska, AE Topolska, B Lige, B Shen, BF Kafsack, BJ Luft, C Lord, CA Hunter, Chetan E. Chitnis, Christian Slomianny, CY He, D Richard, DL Alexander, F Parussini, H El Hajj, HC Hoppe, HC Hoppe, I Mellman, J Schrevel, JB Dacks, JC Boothroyd, JE Rothman, JF Dubremetz, JM Harper, K Kremer, K Miranda, KA Joiner, KA Joiner, KM Hager, L Pelletier, L Sheiner, LH Bannister, LH Bannister, LM Kats, M Elias, M Tufet-Bayona, M Yang, Markus Meissner, ME Francia, MH Ngo, MH Ngo, MK Shaw, MS Breinich, MS Marks, NA Counihan, PJ Bradley, PJ Sloves, S Mogelsvang, SD Brydges, Stanislas Tomavo, VB Carruthers, Vern B. Carruthers, WM Henne, X Que, Z Dou   +54 more
core   +2 more sources

Rab5- and Dynamin-Dependent Endocytosis of KCa2.3 [PDF]

Biophysical Journal, 2011
We recently demonstrated that plasma membrane localized KCa2.3 is rapidly recycled back to the cell surface in a Rab35/EPI64C and RME-1-dependent manner following endocytosis. Herein, we report our initial studies designed to elucidate the mechanism by which KCa2.3 is retrieved from the plasma membrane.
Gao, Yajuan, Devor, Daniel C.
openaire   +1 more source

Simultaneous Visualization of Distinct Posttranslational Modification States of β‐Catenin Using Genetic Code Expansion and Click Chemistry

ChemBioChem, Volume 27, Issue 1, January 2026.
A method to visualize, within the same cell, three distinct posttranslational forms of β‐catenin: wild‐type, phosphomimetic (T41E), and synthetic T41C‐GlcNAc, using genetic code expansion and fluorescence microscopy is developed. This strategy reveals how modifications at T41 alter β‐catenin localization and stability. A novel strategy based on genetic
Christer Abou Anny, Sébastien Nouaille, Isabelle Huvent, Corentin Spriet, Céline Schulz, Fabrice Bray, Régis Fauré, Tony Lefebvre, Christophe Biot   +8 more
wiley   +1 more source

Rab5-independent activation and function of yeast Rab7-like protein, Ypt7p, in the AP-3 pathway.

PLoS ONE, 2019
The small GTPases, Rab5 and Rab7, are key regulators at multiple stages of the endocytic/endolysosomal pathway, including fusion and maturation of endosomes. In yeast, Vps21p (Rab5 homolog) recruits a GEF for Rab7 and activates the downstream Ypt7p (Rab7
Hiroki Shimamura, Makoto Nagano, Keita Nakajima, Junko Y Toshima, Jiro Toshima   +4 more
doaj   +1 more source

Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system [PDF]

, 2014
T cell activation requires sustained signaling at the immune synapse (IS), a specialized interface with the APC that assembles following TCR engagement by MHC-bound peptide.
Baldari, Batista, Bonello, Capitani, Das, Ehrlich, Finetti, Finetti, Follit, Follit, Fooksman, Gerdes, Gomez, Gorska, Hutagalung, Iezzi, Jin, Jékely, Keady, Kumar, Larghi, Li, Lim, Liu, Manders, Margadant, Maxfield, Mayle, Omori, Pampliega, Patino-Lopez, Patrussi, Pazour, Pazour, Pedersen, Pérez-Martínez, Qin, Salmerón, Schafer, Sedmak, Soares, Sönnichsen, Vardhana, Wood, Yudushkin   +44 more
core   +1 more source