Results 101 to 110 of about 25,169 (206)

Vesicular transport of a ribonucleoprotein to mitochondria

Biology Open, 2014
Intracellular trafficking of viruses and proteins commonly occurs via the early endosome in a process involving Rab5. The RNA Import Complex (RIC)-RNA complex is taken up by mammalian cells and targeted to mitochondria.
Joyita Mukherjee, Biraj Mahato, Samit Adhya   +2 more
doaj   +1 more source

The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways

Biochemistry Research International, 2020
Ras analog in brain (Rab) proteins are small guanosine triphosphatases (GTPases) that belong to the Ras-like GTPase superfamily, and they can regulate vesicle trafficking.
Wanqiong Yuan, Chunli Song
doaj   +1 more source

Defective axonal transport in motor neuron disease [PDF]

, 2007
Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas, Blair, Boillee, Bommel, Borchelt, Bowling, Brown, Bruijn, Burger, Cao, Cleveland, Cleveland, Duchen, Escurat, Evans, Fichera, Fliegner, Gaudette, Goldstein, Hadano, Hafezparast, Hazan, Hirokawa, Hirokawa, Hirokawa, Jablonka, Joshi, Kanai, Kaplan, Kieran, King, Kong, LaMonte, Levy, Ligon, Liu, Lo Giudice, Lu, Martin, Miki, Miki, Mitsumoto, Mitsumoto, Muglia, Munch, Nicholson, Nishimura, Okabe, Otomo, Parkinson, Parysek, Pasinelli, Patel, Proukakis, Puls, Puls, Quenneville, Rao, Reid, Reid, Reid, Rosen, Ross, Rowland, Sanderson, Schmitt-John, Shaw, Shibata, Siegel, Song, Teuchert, Troy, Vallee, Weber, Williamson, Wood, Xia, Zhao   +77 more
core   +1 more source

Structural and Functional Characterization of EXPO‐Derived Extracellular Vesicles in Plants

Advanced Science, Volume 13, Issue 14, 9 March 2026.
In this study, 3D electron tomography (ET), cryo‐ET, and immunogold transmission electron microscopy (TEM) are employed to characterize plant extracellular vesicles (EVs) under physiological conditions. EVs are classified into three distinct categories according to their size, content, and molecular‐marker profiles. Furthermore, Exo70E2‐positive medium
Jiayang Gao, Yanbin Li, Shengqi Zhang, Yilin He, Zhiqi Liu, Juan Wang, Jingmin Hua, Jinyu Chen, Junru Zhong, Huan Zhong, Yiji Xia, Yong Cui, Liwen Jiang   +12 more
wiley   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Expression profile of Rab5, Rab7, tryptophan aspartate-containing coat protein, leprae lipoarabinomannan, and phenolic glycolipid-1 on the failure of the phagolysosome process in macrophages of leprosy patients as a viability marker of Mycobacterium leprae

International Journal of Mycobacteriology, 2016
Objective/Background: Phagolysosome process in macrophage of leprosy patients' is important in the early phase of eliminating Mycobacterium leprae invasion.
Cita Rosita Sigit Prakoeswa, Ratna Wahyuni, Iswahyudi, Dinar Adriaty, Irawan Yusuf, Sutjipto, Indropo Agusni, Shinzo Izumi   +7 more
doaj   +1 more source

The late endocytic Rab39a GTPase regulates the interaction between multivesicular bodies and chlamydial inclusions. [PDF]

, 2015
Given their obligate intracellular lifestyle, Chlamydia trachomatis ensure their access to multiple host sources of essential lipids by interfering vesicular transport.
Capmany, Anahi, Damiani, Maria Elena, Gambarte Tudela, Julian Alberto, Goud, Bruno, Miserey Lenkei, Stephanie, Quintero, Cristian Andres, Raposo, Graça, Romao, Maryse   +7 more
core   +1 more source

Rab5- and Dynamin-Dependent Endocytosis of KCa2.3 [PDF]

Biophysical Journal, 2011
We recently demonstrated that plasma membrane localized KCa2.3 is rapidly recycled back to the cell surface in a Rab35/EPI64C and RME-1-dependent manner following endocytosis. Herein, we report our initial studies designed to elucidate the mechanism by which KCa2.3 is retrieved from the plasma membrane.
Gao, Yajuan, Devor, Daniel C.
openaire   +1 more source

Rab5-independent activation and function of yeast Rab7-like protein, Ypt7p, in the AP-3 pathway.

PLoS ONE, 2019
The small GTPases, Rab5 and Rab7, are key regulators at multiple stages of the endocytic/endolysosomal pathway, including fusion and maturation of endosomes. In yeast, Vps21p (Rab5 homolog) recruits a GEF for Rab7 and activates the downstream Ypt7p (Rab7
Hiroki Shimamura, Makoto Nagano, Keita Nakajima, Junko Y Toshima, Jiro Toshima   +4 more
doaj   +1 more source

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion [PDF]

, 2013
Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites
A Fomovska, AE Topolska, B Lige, B Shen, BF Kafsack, BJ Luft, C Lord, CA Hunter, Chetan E. Chitnis, Christian Slomianny, CY He, D Richard, DL Alexander, F Parussini, H El Hajj, HC Hoppe, HC Hoppe, I Mellman, J Schrevel, JB Dacks, JC Boothroyd, JE Rothman, JF Dubremetz, JM Harper, K Kremer, K Miranda, KA Joiner, KA Joiner, KM Hager, L Pelletier, L Sheiner, LH Bannister, LH Bannister, LM Kats, M Elias, M Tufet-Bayona, M Yang, Markus Meissner, ME Francia, MH Ngo, MH Ngo, MK Shaw, MS Breinich, MS Marks, NA Counihan, PJ Bradley, PJ Sloves, S Mogelsvang, SD Brydges, Stanislas Tomavo, VB Carruthers, Vern B. Carruthers, WM Henne, X Que, Z Dou   +54 more
core   +2 more sources