Results 101 to 110 of about 23,291 (205)
RAB family gene expression in breast cancer cells under influence of paclitaxel [PDF]
, 2011 The aim of this study was to investigate the role of paclitaxel on RAB family of genes in primary breast cancer cell lines. The cancer breast cells obtained from 40 women during mastectomy were used to address this issue. The group included patients with
Andrzej Wilkolaski +3 more
core +1 more source
The late endocytic Rab39a GTPase regulates the interaction between multivesicular bodies and chlamydial inclusions. [PDF]
, 2015 Given their obligate intracellular lifestyle, Chlamydia trachomatis ensure their access to multiple host sources of essential lipids by interfering vesicular transport.
Capmany, Anahi +7 more
core +1 more source
Spatiotemporal dynamics of β‐arrestin‐mediated Src activation in 5‐HT7 receptor signaling pathway
The FEBS Journal, EarlyView.GPCRs induce distinct cellular responses via G protein‐ or β‐arrestin‐mediated signaling pathways. This study revealed that β‐arrestin‐biased 5‐HT7R ligand induces slow, sustained Src activation, contrasting with transient G protein‐mediated activation.
Hyunbin Kim +8 more
wiley +1 more source
A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells [PDF]
, 2011 Background Methuosis is a unique form of non-apoptotic cell death triggered by alterations in the trafficking of clathrin-independent endosomes, ultimately leading to extreme vacuolization and rupture of the cell.
Jean H Overmeyer +3 more
core +2 more sources
A new Rab7 effector controls phosphoinositide conversion in endosome maturation [PDF]
Journal of Cell Biology, 2017 Endosome maturation requires a coordinated change in the Rab GTPase and phosphoinositide composition of the endosomal membrane. In this issue, Liu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201705151) identify WDR91 as a ubiquitous Rab7 effector that inhibits phosphatidylinositol 3-kinase activity on endosomes and is critical for endosome ...
James E. Casanova, Bettina Winckler
openaire +2 more sources
Plant Biotechnology Journal, EarlyView.ABSTRACT Hydrogen gas (H2) effectively alleviates abiotic stress in horticultural plants. Protein S‐nitrosylation, a key post‐translational modification, serves as a critical mechanism for nitric oxide (NO) to exert its biological function under adverse conditions.
Hua Fang +12 more
wiley +1 more source
Cancer: Linking Powerhouses to Suicidal Bags. [PDF]
, 2017 Membrane-bound organelles are integrated into cellular networks and work together for a common goal: regulating cell metabolism, cell signaling pathways, cell fate, cellular maintenance, and pathogen defense.
Fajas, L. +2 more
core +1 more source
Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse
Experimental Physiology, EarlyView.Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley +1 more source
The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer [PDF]
, 2016 Breast Cancer Associated gene 2 (BCA2) is an E3 ubiquitin ligase that is over-expressed in >50% of primary breast cancers, and has been shown to increase in vitro cell proliferation and invasion.
Clague, MJ +5 more
core +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
wiley +1 more source