Results 101 to 110 of about 23,457 (205)

Resolving the homology-function relationship through comparative genomics of membrane-trafficking machinery and parasite cell biology [PDF]

, 2016
With advances in DNA sequencing technology, it is increasingly common and tractable to informatically look for genes of interest in the genomic databases of parasitic organisms and infer cellular states.
Aaron P. Turkewitz, Agop-Nersesian, Agop-Nersesian, Asaoka, Asaoka, Barlowe, Barth, Bashline, Baum, Bañuelos, Beck, Bennett, Biller, Blanc, Bonifacino, Bonifacino, Bradley, Braun, Bright, Briguglio, Briguglio, Buczynski, Cai, Cai, Cardona-López, Castillo-Romero, Charette, Chavrier, Chen, Chen, Choi, Chow, Christen M. Klinger, Chung, Cui, Dacks, Dacks, Dettmer, Di Rubbo, Dieckmann, Diekmann, Dutta, Ebine, Ebine, Elde, Elias, Elias, Elliott, Emily K. Herman, Essid, Ezougou, Fan, Faso, Feraru, Field, Field, Field, Fitch, Francia, Fuji, Gabernet-Castello, Gadeyne, Gao, Gao, Giansanti, Gillingham, Gotthardt, Gotthardt, Haas, Hall, Harding, Harper, Harris, Hashiguchi, Henne, Herman, Hirst, Hirst, Hirst, Huotari, Il Kwon, Il Kwon, Inmaculada Ramirez-Macias, Isono, Jackson, Jacobs, Jaillais, Jimenez-Ruiz, Joel B. Dacks, Kang, Katsiarimpa, Kibria, Kim, Kleine-Vehn, Klinger, Knödler, Kolb, Komsic-Buchmann, Komsic-Buchmann, Koonin, Koumandou, Koumandou, Krai, Kremer, Kumar, Lee, Lefkir, Lefkir, Leung, Lunn, López-Reyes, Macro, Manil-Segalén, Manna, Manna, Marion, Mark C. Field, Mattei, McGugan, Mercanti, Miranda, Miras, Mitra, Morrison, Munch, Müller-Taubenberger, Nakada-Tsukui, Neuhaus, Ngô, Ngô, Niemes, Nishimura, Niyogi, Nodzynski, Nordmann, Okada, Okada, Oliviusson, Ouologuem, Pal, Pal, Park, Parkinson, Parussini, Perez-Linero, Pourcher, Preuss, Preuss, Price, Ralston, Rauch, Reider, Reyes, Rink, Rivero, Rivero, Robibaro, Robinson, Robinson, Rojas, Rupper, Rupper, Saito-Nakano, Sangaré, Scheuring, Schlacht, Schlacht, Seaman, Seaman, Shahriari, Shimada, Silverman, Silverman, Singh, Sloves, Sohn, Song, Sosa, Spitzer, Spitzer, Spitzer, Srinivasan, Stenmark, Szumlanski, Tarnita, Tazeh, Teh, Teixeira, Temesvari, Thole, Tomavo, Touz, Touz, Ueda, Ueda, Ulrich, Viotti, Wampfler, Wang, Wang, Welz, Wen, Winter, Woo, Wurmser, Yamaoka, Yamazaki, Yang, Zelazny, Zelazny, Zoltner   +210 more
core   +2 more sources

RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension

The Journal of Clinical Investigation
Pulmonary arterial hypertension (PAH) is a devastating and progressive disease with limited treatment options. Endothelial dysfunction plays a central role in the development and progression of PAH, yet the underlying mechanisms are incompletely ...
Bryce Piper, Srimathi Bogamuwa, Tanvir Hossain, Daniela Farkas, Lorena Rosas, Adam C. Green, Geoffrey Newcomb, Nuo Sun, Jose A. Ovando-Ricardez, Jeffrey C. Horowitz, Aneel R. Bhagwani, Hu Yang, Tatiana V. Kudryashova, Mauricio Rojas, Ana L. Mora, Pearlly Yan, Rama K. Mallampalli, Elena A. Goncharova, David M. Eckmann, Laszlo Farkas   +19 more
doaj   +1 more source

Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase [PDF]

, 2003
Phagosomal biogenesis is central for microbial killing and antigen presentation by leukocytes. However, the molecular mechanisms governing phagosome maturation are poorly understood.
Bucci, Cecilia, Gernstein, Sergio, Gruenberg, Jean, Harrison, Rene E, Lanzetti, Letizia, Schreiber, Alan, Stahl, Philip D, Trimble, William S, Vieira, Otilia V   +8 more
core   +3 more sources

Nur77 Regulates the Phosphorylation of Smad3, Thereby Influencing Skeletal Muscle Fibrosis Caused by Obesity

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
Skeletal muscle fibrosis stems from abnormal extracellular matrix accumulation due to excessive production or reduced degradation of collagen. Obesity induces this fibrosis, along with muscle atrophy and impaired regeneration. Nur77, a transcription factor encoded by NR4A1, is involved in diverse life activities.
Na Li, Tingting Tian, Qihe Zhao, Difei Wang   +3 more
wiley   +1 more source

A new Rab7 effector controls phosphoinositide conversion in endosome maturation [PDF]

Journal of Cell Biology, 2017
Endosome maturation requires a coordinated change in the Rab GTPase and phosphoinositide composition of the endosomal membrane. In this issue, Liu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201705151) identify WDR91 as a ubiquitous Rab7 effector that inhibits phosphatidylinositol 3-kinase activity on endosomes and is critical for endosome ...
James E. Casanova, Bettina Winckler
openaire   +2 more sources

Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system [PDF]

, 2014
T cell activation requires sustained signaling at the immune synapse (IS), a specialized interface with the APC that assembles following TCR engagement by MHC-bound peptide.
Baldari, Batista, Bonello, Capitani, Das, Ehrlich, Finetti, Finetti, Follit, Follit, Fooksman, Gerdes, Gomez, Gorska, Hutagalung, Iezzi, Jin, Jékely, Keady, Kumar, Larghi, Li, Lim, Liu, Manders, Margadant, Maxfield, Mayle, Omori, Pampliega, Patino-Lopez, Patrussi, Pazour, Pazour, Pedersen, Pérez-Martínez, Qin, Salmerón, Schafer, Sedmak, Soares, Sönnichsen, Vardhana, Wood, Yudushkin   +44 more
core   +1 more source

CCDC41 Drives Oocyte Meiotic Progression by Promoting Rab11a/Rab7‐Positive Vesicle Fusion with Target Membranes

Advanced Science, Volume 13, Issue 8, 9 February 2026.
CCDC41 is essential for meiotic maturation in mouse oocytes through regulating Rab7‐positive endosomes fusion with lysosomes and Rab11a‐positive vesicle fusion with the plasma membrane. Abstract Coiled‐coil domain‐containing protein 41 (CCDC41), a core component of centriolar distal appendages involved in centriole assembly and ciliary vesicle docking,
Ying Tian, Jiatong Li, Jingyi Kang, Xiangning Xu, Bicheng Wang, Shuo Lou, Jingyu Li, Yuying Yang, Yanbing Zhang, Yangzi Zheng, Jing Weng, Yuanjing Liang, Wei Ma   +12 more
wiley   +1 more source

Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. [PDF]

, 2015
Defective hepatic insulin receptor (IR) signalling is a pathogenic manifestation of metabolic disorders including obesity and diabetes. The endo/lysosomal trafficking system may coordinate insulin action and nutrient homeostasis by endocytosis of IR and ...
Burnol, Anne-Françoise, Guan, Kun-Liang, Montagnac, Guillaume, Morzyglod, Lucille, Nemazanyy, Ivan, Panasyuk, Ganna, Pende, Mario, Russell, Ryan C   +7 more
core   +1 more source

Smart Nanoparticles Disrupting Energy Supply through Triple Mechanisms to Kill Tumors via Dual Disruption of Mitochondria and Lysosomes

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study introduces a biomimetic nanoplatform (MTCA@C) designed for precise cancer therapy. It targets mitochondria to induce dysfunction through photodynamic activation, while concurrently blocking mitophagy via lysosomal alkalinization. The platform further triggers methuosis, resulting in tumor cell death through vacuolization and energy pathway ...
Xiao Xu, Qiqing Huang, Yang Liu, Jinzhuo Liu, Deyi Yang, Yanni Song, Xin Han   +6 more
wiley   +1 more source

Unconventional Secretion of Angiogenic Sonic Hedgehog–Containing Extra‐Large Extracellular Vesicles is Driven by PI3K–Rab18‐GDP Signalling

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
Human mesenchymal stem cells conditionally secrete sonic hedgehog (SHH)‐containing extra‐large extracellular vesicles (XLEVs) upon PI3K activation, which enriches the GDP‐bound form of Rab18. Rab18‐GDP drives perinuclear maturation and polarized vertical release of SHH‐XLEVs via Hsp90α‐ and nSMase2‐dependent mechanisms.
Shuo Wang, Rio Imai, Yuya Kaneko, Yosuke Tanaka   +3 more
wiley   +1 more source