Results 111 to 120 of about 23,291 (205)

Phenotypic and genetic resistance to Septoria blotch disease in European wheat varieties

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Zymoseptoria tritici, the causal agent of Septoria tritici blotch (STB), poses a critical threat to wheat (Triticum aestivum L.) production in temperate Europe, underscoring the need for durable genetic resistance. Here, we screened 151 winter wheat varieties at the seedling stage using a mixed inoculum of five virulent isolates.
Conor Copeland, Julio Isidro y Sánchez, Humberto Fanelli, Fiona M. Doohan   +3 more
wiley   +1 more source

Salmonella Disrupts Host Endocytic Trafficking by SopD2-Mediated Inhibition of Rab7

Cell Reports, 2015
Intracellular bacterial pathogens of a diverse nature share the ability to evade host immunity by impairing trafficking of endocytic cargo to lysosomes for degradation, a process that is poorly understood.
Vanessa M. D’Costa, Virginie Braun, Marija Landekic, Rong Shi, Ariane Proteau, Laura McDonald, Miroslaw Cygler, Sergio Grinstein, John H. Brumell   +8 more
doaj   +1 more source

MiniCORVET is a Vps8-containing hemocyte- and nephrocyte-specific early endosomal tether in Drosophila [PDF]

, 2016
Yeast studies identified two heterohexameric tethering complexes, which consist of 4 shared (Vps11, Vps16, Vps18 and Vps33) and 2 specific subunits: Vps3 and Vps8 (CORVET) versus Vps39 and Vps41 (HOPS).
Akbar, Baker, Balderhaar, Balderhaar, Bechtel, Belyaeva, Bröcker, Csordás, Gillingham, Guan, Hong, Jiang, Kim, Klinger, Koenig, Kosaka, Kurucz, Kurucz, Kümmel, Lachmann, Li, Lindmo, Lloyd, Lu, Markgraf, Morrison, Munier, Márkus, Ostrowicz, Patterson, Peplowska, Perini, Peterson, Plemel, Port, Pulipparacharuvil, Richardson, Rieder, Rusten, Schuldiner, Seals, Sevrioukov, Shestopal, Solinger, Srivastava, Südhof, Takáts, Takáts, Tanaka, van der Kant, Warner, Wartosch, Weavers, Wickner, Wucherpfennig, Wurmser, Zhang, Zhuang, Zick   +58 more
core   +3 more sources

Phyllanthus emblica Exerts Therapeutic Potential in Oral Cancer Through Multiple Pathways

eFood, Volume 7, Issue 2, April 2026.
Graphic Illustration of the Multifaceted Therapeutic Potential of PEWE, 1. Phyllanthus emblica water extract (PEWE) demonstrates potent anticancer effects against oral cancer by inhibiting cell proliferation, migration, and invasion while inducing apoptosis and autophagy. 2.
Tai‐Pei Lin, Min‐Hsiung Pan, Chan‐Hua Chang, Kuan‐Chung Hsiao, Yen‐Lin Chen, Jui‐Sheng Lai, Wen‐Chan Yang, Ann‐Joy Cheng, Yin‐Ju Chen, Chiou‐Ying Yang, Meng‐Yuan Huang, Ko‐Jiunn Liu   +11 more
wiley   +1 more source

Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. [PDF]

, 2015
Defective hepatic insulin receptor (IR) signalling is a pathogenic manifestation of metabolic disorders including obesity and diabetes. The endo/lysosomal trafficking system may coordinate insulin action and nutrient homeostasis by endocytosis of IR and ...
Burnol, Anne-Françoise, Guan, Kun-Liang, Montagnac, Guillaume, Morzyglod, Lucille, Nemazanyy, Ivan, Panasyuk, Ganna, Pende, Mario, Russell, Ryan C   +7 more
core   +1 more source

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis

eLife
Inflammation in ulcerative colitis is typically restricted to the mucosal layer of distal gut. Disrupted mucus barrier, coupled with microbial dysbiosis, has been reported to occur prior to the onset of inflammation.
Preksha Gaur, Yesheswini Rajendran, Bhagyashree Srivastava, Manasvini Markandey, Vered Fishbain-Yoskovitz, Gayatree Mohapatra, Aamir Suhail, Shikha Chaudhary, Shaifali Tyagi, Subhash Chandra Yadav, Amit Kumar Pandey, Yifat Merbl, Avinash Bajaj, Vineet Ahuja, Chittur Srikanth   +14 more
doaj   +1 more source

Resolving the homology-function relationship through comparative genomics of membrane-trafficking machinery and parasite cell biology [PDF]

, 2016
With advances in DNA sequencing technology, it is increasingly common and tractable to informatically look for genes of interest in the genomic databases of parasitic organisms and infer cellular states.
Aaron P. Turkewitz, Agop-Nersesian, Agop-Nersesian, Asaoka, Asaoka, Barlowe, Barth, Bashline, Baum, Bañuelos, Beck, Bennett, Biller, Blanc, Bonifacino, Bonifacino, Bradley, Braun, Bright, Briguglio, Briguglio, Buczynski, Cai, Cai, Cardona-López, Castillo-Romero, Charette, Chavrier, Chen, Chen, Choi, Chow, Christen M. Klinger, Chung, Cui, Dacks, Dacks, Dettmer, Di Rubbo, Dieckmann, Diekmann, Dutta, Ebine, Ebine, Elde, Elias, Elias, Elliott, Emily K. Herman, Essid, Ezougou, Fan, Faso, Feraru, Field, Field, Field, Fitch, Francia, Fuji, Gabernet-Castello, Gadeyne, Gao, Gao, Giansanti, Gillingham, Gotthardt, Gotthardt, Haas, Hall, Harding, Harper, Harris, Hashiguchi, Henne, Herman, Hirst, Hirst, Hirst, Huotari, Il Kwon, Il Kwon, Inmaculada Ramirez-Macias, Isono, Jackson, Jacobs, Jaillais, Jimenez-Ruiz, Joel B. Dacks, Kang, Katsiarimpa, Kibria, Kim, Kleine-Vehn, Klinger, Knödler, Kolb, Komsic-Buchmann, Komsic-Buchmann, Koonin, Koumandou, Koumandou, Krai, Kremer, Kumar, Lee, Lefkir, Lefkir, Leung, Lunn, López-Reyes, Macro, Manil-Segalén, Manna, Manna, Marion, Mark C. Field, Mattei, McGugan, Mercanti, Miranda, Miras, Mitra, Morrison, Munch, Müller-Taubenberger, Nakada-Tsukui, Neuhaus, Ngô, Ngô, Niemes, Nishimura, Niyogi, Nodzynski, Nordmann, Okada, Okada, Oliviusson, Ouologuem, Pal, Pal, Park, Parkinson, Parussini, Perez-Linero, Pourcher, Preuss, Preuss, Price, Ralston, Rauch, Reider, Reyes, Rink, Rivero, Rivero, Robibaro, Robinson, Robinson, Rojas, Rupper, Rupper, Saito-Nakano, Sangaré, Scheuring, Schlacht, Schlacht, Seaman, Seaman, Shahriari, Shimada, Silverman, Silverman, Singh, Sloves, Sohn, Song, Sosa, Spitzer, Spitzer, Spitzer, Srinivasan, Stenmark, Szumlanski, Tarnita, Tazeh, Teh, Teixeira, Temesvari, Thole, Tomavo, Touz, Touz, Ueda, Ueda, Ulrich, Viotti, Wampfler, Wang, Wang, Welz, Wen, Winter, Woo, Wurmser, Yamaoka, Yamazaki, Yang, Zelazny, Zelazny, Zoltner   +210 more
core   +2 more sources

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, Volume 183, Issue 7, Page 1578-1601, April 2026.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

Cloning of two genes encoding Rab7 in Paramecium.

Acta Biochimica Polonica, 2005
Rab7 is a small GTPase that plays a crucial role in the regulation of transport from early to late endosomes and lysosomes, phagosome maturation and in lysosomal biogenesis in mammalian cells. It contains conserved and unique sequence elements that mediate its function.
Liliana, Surmacz, Jolanta, Wiejak, Elzbieta, Wyroba   +2 more
openaire   +3 more sources