Results 121 to 130 of about 23,457 (205)

The late endocytic Rab39a GTPase regulates the interaction between multivesicular bodies and chlamydial inclusions. [PDF]

, 2015
Given their obligate intracellular lifestyle, Chlamydia trachomatis ensure their access to multiple host sources of essential lipids by interfering vesicular transport.
Capmany, Anahi, Damiani, Maria Elena, Gambarte Tudela, Julian Alberto, Goud, Bruno, Miserey Lenkei, Stephanie, Quintero, Cristian Andres, Raposo, Graça, Romao, Maryse   +7 more
core   +1 more source

The where, what, and when of membrane protein degradation in neurons [PDF]

, 2017
Membrane protein turnover and degradation are required for the function and health of all cells. Neurons may live for the entire lifetime of an organism and are highly polarized cells with spatially segregated axonal and dendritic compartments.
Hiesinger, Peter Robin, Jin, Eugene Jennifer, Kiral, Ferdi Ridvan   +2 more
core   +1 more source

Rab7—a novel redox target that modulates inflammatory pain processing

Pain, 2017
Abstract Chronic pain is accompanied by production of reactive oxygen species (ROS) in various cells that are important for nociceptive processing. Recent data indicate that ROS can trigger specific redox-dependent signaling processes, but the molecular targets of ROS signaling in the nociceptive system remain largely elusive.
Kallenborn-Gerhardt, Wiebke, Möser, Christine V, Lorenz, Jana E, Steger, Mirco, Heidler, Juliana, Scheving, Reynir, Petersen, Jonas, Kennel, Lea, Flauaus, Cathrin, Lu, Ruirui, Edinger, Aimee L, Tegeder, Irmgard, Geisslinger, Gerd, Heide, Heinrich, Wittig, Ilka, Schmidtko, Achim   +15 more
openaire   +4 more sources

Acid Sphingomyelinase Regulates the Localization and Trafficking of Palmitoylated Proteins [PDF]

, 2019
In human, loss of Acid Sphingomeylinase (ASM/SMPD1) causes Niemann-Pick Disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. ...
Kim, Yongsoon, Lee, Chia-Fang, Li, Wenjing, Sun, Hong, Xiong, Xiahui, Yu, Jiekai, Zhang, Hul, Zhu, Linyu   +7 more
core   +2 more sources

Attenuated Leishmania induce pro-inflammatory mediators and influence leishmanicidal activity by p38 MAPK dependent phagosome maturation in Leishmania donovani co-infected macrophages [PDF]

, 2016
Promastigote form of Leishmania, an intracellular pathogen, delays phagosome maturation and resides inside macrophages. But till date limited study has been done to manipulate the phagosomal machinery of macrophages to restrict Leishmania growth ...
A Awasthi, A Sarkar, AF Vinet, AF Vinet, AK Marr, BG Bolscher, C Bucci, C Prive, D Aivazian, D Raoult, DJ Hackam, DorcasS Yole, E Aktas, E Cillari, E del Cerro-Vadillo, E van den Bogaart, EL Eskelinen, F Real, GF Spath, GJ Feng, HW Murray, J Rink, J van Griensven, JM Blander, JY Jung, KR Gantt, KW Beyenbach, L Kedzierski, L Kedzierski, M Bhattacharya, M Desjardins, M Desjardins, M Junghae, M Olivier, ME Winberg, ML Schmitz, MS Gomes, N Courret, N Moradin, NC Peters, OV Vieira, PS Veras, RA Heinzen, RK Mathur, S Bhardwaj, S Duclos, S Ghosh, S Mukhopadhyay, S Mukhopadhyay, S Noazin, S Scianimanico, SD Reid, T Lang, V Cavalli, WK Andreoli, Y Osorio, Z Sun   +56 more
core   +1 more source

Targeting Rab7‐Rilp Mediated Microlipophagy Alleviates Lipid Toxicity in Diabetic Cardiomyopathy

Advanced Science
Diabetic cardiomyopathy (DbCM) is characterized by diastolic dysfunction, which progresses into heart failure and aberrant electrophysiology in diabetic patients.
Jiahan Ke, Jianan Pan, Hao Lin, Shuying Huang, Junfeng Zhang, Changqian Wang, Alex Chia Yu Chang, Jun Gu   +7 more
doaj   +1 more source

Structural and mechanistic insights into regulation of the retromer coat by TBC1d5

Nature Communications, 2016
Retromer is recruited to endosomes by the small GTPase Rab7 and sorting nexin 3. Here, the authors report the interaction between a GTPase-activating protein TBC1d5 and Rab7, examine the biochemical details of the interaction with retromer, and discuss ...
Da Jia, Jin-San Zhang, Fang Li, Jing Wang, Zhihui Deng, Mark A. White, Douglas G. Osborne, Christine Phillips-Krawczak, Timothy S. Gomez, Haiying Li, Amika Singla, Ezra Burstein, Daniel D. Billadeau, Michael K. Rosen   +13 more
doaj   +1 more source

Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation

eLife
The spatiotemporal transition of small GTPase Rab5 to Rab7 is crucial for early-to-late endosome maturation, yet the precise mechanism governing Rab5-to-Rab7 switching remains elusive.
Yue Miao, Yongtao Du, Baolei Wang, Jingjing Liang, Yu Liang, Song Dang, Jiahao Liu, Dong Li, Kangmin He, Mei Ding   +9 more
doaj   +1 more source

Spatio-temporal control of neurotrophin trafficking and signalling in primary neurons cultured inside microfluidic chambers

, 2011
My PhD project was aimed at applying microfluidics technology to the study of longrange neurotrophin signalling. Neurotrophins are target-derived growth and survival factors that, among other functions, prevent innervating neurons from undergoing ...
Menendez, Guillermo, Menendez, Guillermo
core   +1 more source

Defects of mitochondria-lysosomes communication induce secretion of mitochondria-derived vesicles and drive chemoresistance in ovarian cancer cells

Cell Communication and Signaling
Background Among the mechanisms of mitochondrial quality control (MQC), generation of mitochondria-derived vesicles (MDVs) is a process to avoid complete failure of mitochondria determining lysosomal degradation of mitochondrial damaged proteins. In this
Sinforosa Gagliardi, Marco Mitruccio, Riccardo Di Corato, Roberta Romano, Alessandra Aloisi, Rosaria Rinaldi, Pietro Alifano, Flora Guerra, Cecilia Bucci   +8 more
doaj   +1 more source