New Phytologist, Volume 250, Issue 2, Page 799-804, April 2026.Summary Plant immunity is complex, and studies of leaf epidermal cells attacked by powdery mildew fungi have been instrumental in revealing how it relies on plant endomembrane trafficking. Immunity against these biotrophic fungi is manifested as cell wall deposits (‘papillae’) and the hypersensitive reaction (HR), both involving plant endomembrane ...
Hans Thordal‐Christensen +3 more
wiley +1 more source
Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system [PDF]
, 2014 T cell activation requires sustained signaling at the immune synapse (IS), a specialized interface with the APC that assembles following TCR engagement by MHC-bound peptide.
Baldari +44 more
core +1 more source
Regulation of autophagy by the nuclear factor κB signaling pathway in the hippocampus of rats with sepsis [PDF]
, 2015 BACKGROUND: Sepsis with brain dysfunction has contributed to an increase risk of morbidity and mortality. In its pathophysiology, both autophagy and nuclear factor κB (NF-κB) have been suggested to play important roles.
DeZhi Mu +5 more
core +1 more source
Rab7—a novel redox target that modulates inflammatory pain processing
Pain, 2017 Abstract Chronic pain is accompanied by production of reactive oxygen species (ROS) in various cells that are important for nociceptive processing. Recent data indicate that ROS can trigger specific redox-dependent signaling processes, but the molecular targets of ROS signaling in the nociceptive system remain largely elusive.
Kallenborn-Gerhardt, Wiebke +15 more
openaire +4 more sources
Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. [PDF]
, 2012 Cells rely on the coordinated regulation of lipid phosphoinositides and Rab GTPases to define membrane compartment fates along distinct trafficking routes.
Cox, Sarah +4 more
core +1 more source
A postsynaptic PI3K-cII dependent signaling controller for presynaptic homeostatic plasticity. [PDF]
, 2018 Presynaptic homeostatic plasticity stabilizes information transfer at synaptic connections in organisms ranging from insect to human. By analogy with principles of engineering and control theory, the molecular implementation of PHP is thought to require ...
Davis, Graeme W +5 more
core +3 more sources
Targeting Rab7‐Rilp Mediated Microlipophagy Alleviates Lipid Toxicity in Diabetic Cardiomyopathy
Advanced ScienceDiabetic cardiomyopathy (DbCM) is characterized by diastolic dysfunction, which progresses into heart failure and aberrant electrophysiology in diabetic patients.
Jiahan Ke +7 more
doaj +1 more source
Structural and mechanistic insights into regulation of the retromer coat by TBC1d5
Nature Communications, 2016 Retromer is recruited to endosomes by the small GTPase Rab7 and sorting nexin 3. Here, the authors report the interaction between a GTPase-activating protein TBC1d5 and Rab7, examine the biochemical details of the interaction with retromer, and discuss ...
Da Jia +13 more
doaj +1 more source
Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation
eLifeThe spatiotemporal transition of small GTPase Rab5 to Rab7 is crucial for early-to-late endosome maturation, yet the precise mechanism governing Rab5-to-Rab7 switching remains elusive.
Yue Miao +9 more
doaj +1 more source
Cell Communication and SignalingBackground Among the mechanisms of mitochondrial quality control (MQC), generation of mitochondria-derived vesicles (MDVs) is a process to avoid complete failure of mitochondria determining lysosomal degradation of mitochondrial damaged proteins. In this
Sinforosa Gagliardi +8 more
doaj +1 more source