Results 131 to 140 of about 23,457 (205)

Effect of MEHP on testosterone synthesis via Sirt1/Foxo1/Rab7 signaling pathway inhibition of lipophagy in TM3 cells

Ecotoxicology and Environmental Safety
Mono-2-ethylhexyl phthalic acid (MEHP) is the most toxic metabolite of the plasticizer di-2-ethylhexyl phthalic acid (DEHP), and studies have shown that MEHP causes serious reproductive effects. However, its exact mechanisms of action remain elusive.
Yu Hao, Xuan'en Tian, Fengmei Yan, Xiuqin Wang, Jing Huang, Ling Li   +5 more
doaj   +1 more source

PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7

Nature Communications, 2016
Rab7 is a critical GTPase for endosome maturation and it is implicated in the endocytic traffic of several receptors, including EGFR. In this study, the authors reveal the potential role of PTEN in the endocytic trafficking pathway of EGFR, which is ...
Swapnil Rohidas Shinde, Subbareddy Maddika   +1 more
doaj   +1 more source

Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models

Scientific Reports, 2017
Although aberrations of intracellular vesicle transport systems towards lysosomes including autophagy and endocytosis are involved in the onset and progression of acute pancreatitis, the molecular mechanisms underlying such aberrations remain unclear ...
Kenichi Takahashi, Hirosato Mashima, Kouichi Miura, Daichi Maeda, Akiteru Goto, Takashi Goto, Ge-Hong Sun-Wada, Yoh Wada, Hirohide Ohnishi   +8 more
doaj   +1 more source

ML098 enhances intracellular bacterial clearance in bladder epithelial cells by activating Rab7 and promoting lysosomal biogenesis

Bangladesh Journal of Pharmacology
The aim of this study was to investigate the effect of ML098 on the intra-cellular bacterial count of bladder epithelial cells infected with uropathogenic Escherichia coli.
Hao Yin, Jiaoli Zhu, Jiamin Yin, Yi Xue, Xin Wang   +4 more
doaj   +1 more source

On the fate of early endosomes [PDF]

, 2017
Proteins are endocytosed by various pathways into the cell. All these pathways converge at the level of the early endosome. The fate of the early endosome and how proteins are sorted into recycling and late endosomes/multi-vesicular body is a matter of ...
Spang, Anne
core  

Coordination between ESCRT function and Rab conversion during endosome maturation

The EMBO Journal
The endosomal pathway is essential for regulating cell signaling and cellular homeostasis. Rab5 positive early endosomes receive proteins from the plasma membrane.
Daniel P Ott, Samit Desai, Jachen A Solinger, Andres Kaech, Anne Spang   +4 more
doaj   +1 more source

Molecular and functional mapping of Plekhm1-Rab7 interaction in osteoclasts

JBMR Plus
Abstract Mutations in PLEKHM1 cause osteopetrosis in humans and rats. The germline and osteoclast conditional deletions of Plekhm1 gene in mice lead to defective osteoclast bone resorption and increased trabecular bone mass without overt abnormalities in other organs.
Bhaba K, Das, Tarun, Minocha, Mikaela D, Kunika, Aarthi, Kannan, Ling, Gao, Subburaman, Mohan, Weirong, Xing, Kottayil I, Varughese, Haibo, Zhao   +8 more
openaire   +2 more sources

Synthese und biologische Evaluierung semi-synthetischer Rab7-Proteine

, 2003
In the present thesis lipidated fluorescently labelled peptides were synthesized. The peptides correspond to a great extend to the C-terminal area of the membrane bound rab7 protein which acts as a regulator in the intracellular vesicle transport. In addition to the partial sequence analogous to the fully modified i.e.
openaire   +3 more sources

Structure of the Rab7:REP-1 Complex [PDF]

Cell, 2004
Rak, Alexey, Pylypenko, Olena, Niculae, Anca, Pyatkov, Konstantin, Goody, Roger, Alexandrov, Kirill   +5 more
openaire   +2 more sources

Centrosomal P4.1-associated protein is a novel regulator of ESCRT pathway function during endosome maturation. [PDF]

iScience
Gudi R, Vasu C.
europepmc   +1 more source