Results 31 to 40 of about 23,457 (205)

Rab7: A Key to Lysosome Biogenesis

Molecular Biology of the Cell, 2000
The molecular machinery behind lysosome biogenesis and the maintenance of the perinuclear aggregate of late endocytic structures is not well understood. A likely candidate for being part of this machinery is the small GTPase Rab7, but it is unclear whether this protein is associated with lysosomes or plays any role in the regulation of the perinuclear ...
BUCCI, Cecilia, P. THOMSEN, P. NICOZIANI, J. MCCARTHY, B. VAN DEURS   +4 more
openaire   +4 more sources

Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL. [PDF]

, 2019
Clostridium perfringens epsilon toxin (ETX) is responsible for causing the economically devastating disease, enterotoxaemia, in livestock. It is well accepted that ETX causes blood brain barrier (BBB) permeability, however the mechanisms involved in this
Dobrow, Sebastian, Flores, Claudia, Linden, Jennifer R, Michel, Adam O, Schmidt, Eric F, Uzal, Francisco A, Valenzuela, Marissa, Vartanian, Timothy   +7 more
core   +1 more source

Rab7 regulates primary cilia disassembly through cilia excision [PDF]

Journal of Cell Biology, 2019
The primary cilium is a sensory organelle that protrudes from the cell surface. Primary cilia undergo dynamic transitions between assembly and disassembly to exert their function in cell signaling. In this study, we identify the small GTPase Rab7 as a novel regulator of cilia disassembly.
Guang Wang, Huai-Bin Hu, Yan Chang, Yan Huang, Zeng-Qing Song, Shi-Bo Zhou, Liang Chen, Yu-Cheng Zhang, Min Wu, Hai-Qing Tu, Jin-Feng Yuan, Na Wang, Xin Pan, Ai-Ling Li, Tao Zhou, Xue-Min Zhang, Kun He, Hui-Yan Li   +17 more
openaire   +2 more sources

Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics

Molecular & Cellular Oncology, 2020
High-fat diet (HFD)-induced obesity is associated with increased cancer risk. Long-term feeding with HFD increases the concentration of the saturated fatty acid palmitic acid (PA) in the hypothalamus.
María Paz Hernández-Cáceres, Karina Cereceda, Sergio Hernández, Ying Li, Carla Narro, Patricia Rivera, Patricio Silva, Yenniffer Ávalos, Claudia Jara, Paulina Burgos, Lilian Toledo-Valenzuela, Pablo Lagos, Flavia Cifuentes Araneda, Claudio Perez-Leighton, Cristina Bertocchi, Deborah J. Clegg, Alfredo Criollo, Cheril Tapia-Rojas, Patricia V. Burgos, Eugenia Morselli   +19 more
doaj   +1 more source

Rab4 and Rab7 Define Distinct Nonoverlapping Endosomal Compartments [PDF]

Journal of Biological Chemistry, 1996
Several Rab GTPases have been localized to distinct compartments of the endocytic pathway. Rab4 is associated with early endosomes and recycling vesicles and regulates membrane recycling from early endosomes. Rab7 is localized to late endosomes and is involved in the regulation of membrane transport between late endosomes and lysosomes.
G, Bottger, B, Nagelkerken, P, van der Sluijs   +2 more
openaire   +2 more sources

Regulation of Endosomal Trafficking by Rab7 and Its Effectors in Neurons: Clues from Charcot–Marie–Tooth 2B Disease

Biomolecules, 2023
Intracellular endosomal trafficking controls the balance between protein degradation and synthesis, i.e., proteostasis, but also many of the cellular signaling pathways that emanate from activated growth factor receptors after endocytosis.
Ryan J. Mulligan, Bettina Winckler
doaj   +1 more source

Downregulation of RAB7 and Caveolin-1 increases MMP-2 activity in renal tubular epithelial cells under hypoxic conditions

Open Medicine, 2021
Tubulointerstitial fibrosis leads to tubular basement membrane thickening and accumulation of interstitial extracellular matrix (ECM). Matrix metallopeptidase-2 (MMP-2) is involved in the breakdown of ECM.
Yu Wenmin, Ke Xiumei, Li Meiren, Ye Ping, Peng Jing, Li Huimin   +5 more
doaj   +1 more source

The Small GTPase Rab7 Regulates Antigen Processing in B Cells in a Possible Interplay with Autophagy Machinery

Cells, 2023
In B cells, antigen processing and peptide-antigen (pAg) presentation is essential to ignite high-affinity antibody responses with the help of cognate T cells.
Marika Runsala, Elina Kuokkanen, Eveliina Uski, Vid Šuštar, Meryem Özge Balci, Johanna Rajala, Vilma Paavola, Pieta K. Mattila   +7 more
doaj   +1 more source

Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells [PDF]

, 2018
Estrogen receptor α (ERα) is expressed in tissues as diverse as brains and mammary glands. In breast cancer, ERα is a key regulator of tumor progression.
Acconcia, Acconcia, Acerbi, Adlanmerini, Alfredo Cáceres, Ambrose, Andrés M. Toscani, Arjonen, Arnal, Axelrod, Axelrod, Bacia, Bae, Barabas, Bates, Bermudez-Hernandez, Bonifacino, Bradford, Cancer Genome Atlas Network, Caswell, Cerami, Chaumet, Chung, Ciriello, Ciriello, Correia, Cosker, Cosker, Couse, Cox, Dante R. Chialvo, De Franceschi, Debnath, Degasperi, Delcroix, Dozynkiewicz, Dunn, Eirew, Federico Coluccio Leskow, Fernando D. Stefani, Gao, Gao, Ghajar, Gillespie, Gould, Graham, Grant, Han, Han, Hartley, He, Heery, Helleman, Hernández, Hines, Honerkamp-Smith, Ianina L. Violi, Jeselsohn, Johnson, Jonathon N. Lakins, Kate Thi, Kisler, La Rosa, Letoha, Levin, Li, Long, Lu, Lu, Luciano A. Masullo, Luzio, Mak, Marina Simian, Marino, Matthew G. Rubashkin, Mayor, Mayor, Małecki, McDonough, Mina J. Bissell, Moreno-Layseca, Nam, Nardone, Nicovich, Ovesný, Pedram, Pereira, Pietras, Pontiggia, Razandi, Reid, Rocío G. Sampayo, Rust, Savkur, Schindelin, Schlegel, Skliris, Solowska, Su, Sung, Takahashi, Tiwari, Totta, Totta, Upla, Valerie M. Weaver, van de Linde, Vanlandingham, Wang, Waxmonsky, William C. Hines, Yao   +111 more
core   +2 more sources

Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization. [PDF]

Aging Cell
Synaptic vesicle glycoprotein 2A, the newly identified APP‐binding protein, reduces amyloid‐β plaque deposition in Alzheimer's disease by suppressing the amyloidogenic pathway through inhibition of BACE1‐APP interaction and alteration of APP endosomal‐lysosomal localization.
Wang X, Zhang Q, Zhang X, Liu J, Zhang J, Liu C, Cui Y, Song Q, Hou Y, Wang Y, Cao M, Wang P.   +11 more
europepmc   +2 more sources