Results 41 to 50 of about 23,291 (205)

Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy. [PDF]

, 2017
Transverse (T)-tubules make-up a specialized network of tubulated muscle cell membranes involved in excitation-contraction coupling for power of contraction. Little is known about how T-tubules maintain highly organized structures and contacts throughout
Fujita, Naonobu, Fukuda, Mitsunori, Groulx, Jean-Francois, Huang, Wilson, Jean, Steve, Kiger, Amy A, Koyama-Honda, Ikuko, Kuchitsu, Yoshihiko, Lin, Tzu-Han, Mizushima, Noboru, Nguyen, Jen   +10 more
core   +2 more sources

Endo-lysosomal vesicles positive for Rab7 and LAMP1 are terminal vesicles for the transport of dextran.

PLoS ONE, 2011
The endo-lysosomal pathway is essential for intracellular transport and the degradation of extracellular cargo. The relationship between three populations of endo-lysosomal vesicles--Rab7-positive, LAMP1-positive, and both Rab7- and LAMP1-postive--was ...
William H Humphries, Craig J Szymanski, Christine K Payne   +2 more
doaj   +1 more source

Rab7: roles in membrane trafficking and disease

Bioscience Reports, 2009
The endocytosis pathway controls multiple cellular and physiological events. The lysosome is the destination of newly synthesized lysosomal hydrolytic enzymes. Internalized molecules or particles are delivered to the lysosome for degradation through sequential transport along the endocytic pathway. The endocytic pathway is also emerging as a signalling
Zhang, Ming, Chen, Li, Wang, Shicong, Wang, Tuanlao   +3 more
openaire   +3 more sources

Prediction of HBF-0259 interactions with hepatitis B Virus receptors and surface antigen secretory factors [PDF]

, 2016
Hepatitis B virus (HBV) is an etiological agent of viral hepatitis, which may lead to cirrhosis, and hepatocellular carcinoma. Current treatment strategies have not shown promising effect to date but various complications such as, drug toxicity ...
Memarian, A., Mohammadi, S., Mohebbi, A.
core   +1 more source

Rab7 mutants associated with Charcot-Marie-Tooth disease exhibit enhanced NGF-stimulated signaling. [PDF]

PLoS ONE, 2010
Missense mutants in the late endosomal Rab7 GTPase cause the autosomal dominant peripheral neuropathy Charcot-Marie-Tooth disease type 2B (CMT2B). As yet, the pathological mechanisms connecting mutant Rab7 protein expression to altered neuronal function ...
Soumik BasuRay, Sanchita Mukherjee, Elsa Romero, Michael C Wilson, Angela Wandinger-Ness   +4 more
doaj   +1 more source

Rab7 Phosphorylation reaction v1

, 2023
Phosphorylation of Rab7 at S72 using TBK1
openaire   +1 more source

Immunotherapeutic targeting of membrane Hsp70-expressing tumors using recombinant human granzyme B [PDF]

, 2012
Background: We have previously reported that human recombinant granzyme B (grB) mediates apoptosis in membrane heat shock protein 70 (Hsp70)-positive tumor cells in a perforin-independent ...
AL Rerole, Alan G. Pockley, Andreas Kirschner, Axel Walch, Brigitte T. Doß, C Botzler, C Botzler, C Gross, D Kaiserman, D Schilling, DR Ciocca, E Schmitt, FC Kurschus, G MacDonald, G Multhoff, G Multhoff, Gabriele Multhoff, Gemma A. Foulds, H Dertinger, J Friedrich, J Friedrich, J Nylandsted, J Sun, J Thiery, JA Trapani, K Pfister, L Chavez-Galan, M Gehrmann, M Gehrmann, M Gehrmann, M Gehrmann, M Gehrmann, M Wang, Mathias Gehrmann, Michael Platten, MS Buzza, RZ Lin, S Balkow, S Mahrus, S Stangl, S Stangl, SP Cullen, Stefan Stangl, SW Krause, U Giesubel, V Milani, WA Boivin, Wolfgang Sievert, Y Liu, Y Liu, Z Xia   +50 more
core   +2 more sources

Genetic analysis ofrab7mutants in zebrafish

, 2023
AbstractVascular network formation requires the fusion of newly formed blood vessels and the emergence of a patent lumen between the newly established connections so that blood flow can start. Lumen formation has been shown to depend on the late endosomal/lysosomal pathway in various organs of animal tubular systems.
Daniel Heutschi, Etienne Schmelzer, Vahap Aydogan, Alexander Schmidt, Heinz-Georg Belting, Anne Spang, Markus Affolter, Maria P. Kotini   +7 more
openaire   +3 more sources

Defective phagocytic corpse processing results in neurodegeneration and can be rescued by TORC1 activation [PDF]

, 2016
This work was supported by NIH Grants R01 GM094452 (K.M.) and F31 GM099425 (J.I.E.), BU Alzheimer's Disease Core Center NIH Grant P30 AG13846, Boston University Undergraduate Research Opportunities Program grants (J.A.T., V.S.), and NIH Grant R01 ...
Elguero, Emma J., Etchegaray, Jon Iker, Feany, Mel B., McCall, Kimberly, Sinatra, Vincent, Tran, Jennifer A.   +5 more
core   +1 more source

WDR91 is a Rab7 effector required for neuronal development [PDF]

Journal of Cell Biology, 2017
Early-to-late endosome conversion, which is essential for delivery of endosomal cargoes to lysosomes, requires switching of early endosome–specific Rab5 and PtdIns3P to late endosome–specific Rab7 and PtdIns(3,5)P2. In this study, we identify the WD40-repeat protein WDR91 as a Rab7 effector that couples Rab switching with PtdIns3P down-regulation on ...
Kai Liu, Ruxiao Xing, Youli Jian, Zhiyang Gao, Xinli Ma, Xiaojuan Sun, Yang Li, Meng Xu, Xin Wang, Yudong Jing, Weixiang Guo, Chonglin Yang   +11 more
openaire   +2 more sources