Results 1 to 10 of about 8,454 (202)

Supplement With Calcium or Alendronate Suppresses Osteopenia Due to Long Term Rabeprazole Treatment in Female Mice: Influence on Bone TRAP and Osteopontin Levels

open access: yesFrontiers in Pharmacology, 2020
Background and PurposeRabeprazole, a proton pump inhibitor (PPIs) is much endorsed to patients with increased gastric acidity. PPIs were accused to have osteoporotic effects on patients who chronically use them. The point of the current investigation was
Aly A M Shaalan   +2 more
exaly   +3 more sources

Vitamin B12 Deficiency Associated with Metformin and Proton Pump Inhibitors and Their Combinations: Results from a Disproportionality and Interaction Analysis [PDF]

open access: yesDiseases
Background: Metformin and proton pump inhibitors (PPIs) are independently associated with vitamin B12 deficiency. Despite frequent co-prescription, particularly in diabetics with gastroesophageal disorders, evidence regarding the combined risk of these ...
Kannan Sridharan
doaj   +2 more sources

Bioequivalence of a single dose of two palbociclib formulations in healthy Chinese subjects under fasting conditions: a two-period crossover study with rabeprazole pre-treatment [PDF]

open access: yesFrontiers in Pharmacology
ObjectivesThis study assessed the pharmacokinetics, safety, and bioequivalence of generic and original palbociclib tablets in healthy Chinese subjects under fasting conditions with rabeprazole pre-treatment.MethodsThis was a single-dose, randomized, open-
Wanjun Bai   +12 more
doaj   +2 more sources

Current Trends in Treatment for Acid-Dependent Diseases: Clinical Efficacy and Safety of Rabeprazole

open access: yesРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии, 2021
Aim. A comparative review of the rabeprazole properties vs. other PPIs, its efficacy and safety in treatment for aciddependent diseases.Key points. Rabeprazole provides a rapid proton pump blockade in parietal cells due to its high dissociation constant (
O. D. Lopina   +2 more
doaj   +1 more source

Pharmacokinetics and pharmacodynamics of injectable dex-rabrazole for healthy people

open access: yesDi-san junyi daxue xuebao, 2021
Objective To study the pharmacokinetic and pharmacodynamic characteristics of dex-rabeprazole for injection at different doses in healthy subjects and to evaluate its safety.
YU Mingjie   +5 more
doaj   +1 more source

Effect of Rabeprazole and Rebamipide in the Treatment of Upper Gastrointestinal Hemorrhage Associated with Dual Antiplatelet Therapy in Elderly Patients with Coronary Heart Disease

open access: yesClinical and Applied Thrombosis/Hemostasis, 2022
To investigate the therapeutic effect of rabeprazole and rebamipide on patient age over 60 with dual antiplatelet therapy (DAPT)–related upper gastrointestinal hemorrhage following percutaneous coronary intervention (PCI).
Rong-Jie Jia MD   +6 more
doaj   +1 more source

Exploring Differences in Pharmacometrics of Rabeprazole between Genders via Population Pharmacokinetic–Pharmacodynamic Modeling

open access: yesBiomedicines, 2023
Rabeprazole is a proton pump inhibitor that inhibits gastric acid production and increases gastric pH; it is widely used clinically as a treatment option for gastritis and gastric ulcers.
Seung-Hyun Jeong   +2 more
doaj   +1 more source

Repurposing of rabeprazole as an anti-Trypanosoma cruzi drug that targets cellular triosephosphate isomerase

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2023
Trypanosoma cruzi is the causative agent of American trypanosomiasis, which mainly affects populations in Latin America. Benznidazole is used to control the disease, with severe effects in patients receiving this chemotherapy.
Itzhel García-Torres   +9 more
doaj   +1 more source

Effect and safety of anaprazole in the treatment of duodenal ulcers: a randomized, rabeprazole-controlled, phase III non-inferiority study

open access: yesChinese Medical Journal, 2022
. Background:. The pharmacokinetic and clinical behaviors of many proton pump inhibitors (PPIs) in peptic ulcer treatment are altered by CYP2C19 genetic polymorphisms.
Huiyun Zhu   +13 more
doaj   +1 more source

Efficacy and Tolerability of 14-Day Tegoprazan- versus Rabeprazole-Based Triple Therapy for Eradication of Helicobacter pylori: A Real-World Evidence Study

open access: yesGut and Liver, 2023
Background/Aims: Tegoprazan, a new, fast, and strong potassium-competitive acid blocker, has been approved for the treatment of gastric acid-related diseases in Korea. However, real-world clinical data regarding this drug are scarce.
Yoon Suk Jung   +6 more
doaj   +1 more source

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