Results 11 to 20 of about 8,454 (202)

Rabeprazole inhibits inflammatory reaction by inhibition of cell pyroptosis in gastric epithelial cells

BMC Pharmacology and Toxicology, 2021
Background Helicobacter pylori (H. pylori) is a common pathogen in development of peptic ulcers with pyroptosis. Rabeprazole, a critical component of standard triple therapy, has been widely used as the first-line regimen for H.
Jing Xie, Long Fan, Liya Xiong, Peiyu Chen, Hongli Wang, Huan Chen, Junhong Zhao, Zhaohui Xu, Lanlan Geng, Wanfu Xu, Sitang Gong   +10 more
doaj   +1 more source

EFFECTIVENESS OF RABEPRAZOLE FOR THE TREATMENT OF ACID-RELATED DISEASES

Медицинский совет, 2017
The analysis of modern data about the effectiveness of rabeprazole in the treatment of acid-related diseases is performed. The European Consensus Maastricht 5 recommends a preferred use of rabeprazole in the schemes of eradication of Helicobacter pylori.
V. V. Tsukanov, E. V. Kasparov, A. V. Vasyutin, Y. L. Tonkikh, O. V. Peretyatko   +4 more
doaj   +1 more source

Rabeprazole Promotes Vascular Repair and Resolution of Sepsis-Induced Inflammatory Lung Injury through HIF-1α

Cells, 2022
There are currently no effective treatments for sepsis and acute respiratory distress syndrome (ARDS). The repositioning of existing drugs is one possible effective strategy for the treatment of sepsis and ARDS.
Colin E. Evans, Yi Peng, Maggie M. Zhu, Zhiyu Dai, Xianming Zhang, You-Yang Zhao   +5 more
doaj   +1 more source

Safe use of proton pump inhibitors in patients with cirrhosis [PDF]

, 2018
Aims: Proton pump inhibitors (PPIs) belong to the most frequently used drugs, also in patients with cirrhosis. PPIs are extensively metabolized by the liver, but practice guidance on prescribing in cirrhosis is lacking.
Borgsteede, S.D. (Sander), Bouma, M. (Margriet), Burger, D.M. (David), Drenth, J.P.H. (Joost), Harkes-Idzinga, S.F. (S. Froukje), Hunfeld, N.G.M. (Nicole), Metselaar, H.J. (Herold), Monster-Simons, M.H. (Margje H.), Taxis, K. (Katja), van Putten, S.A.W. (Sandra A.W.), Weersink, R.A. (Rianne A.)   +10 more
core   +8 more sources

The choice of proton pump inhibitor from the standpoint of efficacy and safety in a particular patient

Лечащий Врач, 2021
Proton pump inhibitors are a diverse class of drugs with unique acid suppression properties. The aim of the work was to present the therapeutic benefits of rabeprazole and pantoprazole in clinical practice.
E. A. Lyalukova, Yu. V. Tereschenko, E. N. Chernysheva, A. V. Lyalukov   +3 more
doaj   +1 more source

The effects of rabeprazole on metformin pharmacokinetics and pharmacodynamics in Chinese healthy volunteers

Journal of Pharmacological Sciences, 2016
The aim was to investigate the role of rabeprazole on the pharmacokinetics (PK) and pharmacodynamics (PD) of metformin. The in vitro inhibition assays on metformin transport were carried out and showed that the half maximal inhibitory concentration (IC50)
Guojing Liu, Jiagen Wen, Dong Guo, Zhenmin Wang, Xiaolei Hu, Jie Tang, Zhaoqian Liu, Honghao Zhou, Wei Zhang   +8 more
doaj   +1 more source

Influence of rabeprazole and famotidine on pharmacodynamic profile of dual antiplatelet therapy in clopidogrel-sensitive patients: The randomized, prospective, PROTECT trial

Platelets, 2020
Although acid suppressants are needed to attenuate gastrointestinal bleeding (GIB) after percutaneous coronary intervention (PCI), pharmacodynamic interaction between clopidogrel and proton pump inhibitor (PPI) can increase the risk of high platelet ...
Jong-Hwa Ahn, Yongwhi Park, Jae Seok Bae, Jeong Yoon Jang, Kye-Hwan Kim, Min Gyu Kang, Jin-Sin Koh, Jeong Rang Park, Seok-Jae Hwang, Choong Hwan Kwak, Jin-Yong Hwang, Young-Hoon Jeong   +11 more
doaj   +1 more source

Pharmacologic Properties of Proton Pump Inhibitors [PDF]

, 2003
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90231/1/phco.23.13.74S.31929 ...
Welage, Lynda S.
core   +1 more source

ACTUAL ASPECTS OF ANTI-SECRETOR THERAPY OF GASTROESOPHAGEAL REFLUX DISEASE

Медицинский совет, 2017
In recent years, GERD has attracted increased attention, which is associated with a clear tendency to increase the incidence of the disease. Adequate treatment of GERD is necessary, as this disease worsens the quality of life of patients, and prolonged ...
D. I. Trukhan, I. A. Grishechkina
doaj   +1 more source

Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase [PDF]

, 2014
Fatty acid synthase (FASN), the enzyme responsible for de novo synthesis of free fatty acids, is up-regulated in many cancers. FASN is essential for cancer cell survival and contributes to drug resistance and poor prognosis.
Fako, Valerie E., Liu, Jing-Yuan, Pflug, Beth, Wu, Xi, Zhang, Jian-Ting   +4 more
core   +5 more sources