Results 121 to 130 of about 131,005 (322)
Journal of Medicinal Plants, 2019 Background: Hypertension induced-left ventricular hypertrophy (LVH) is, at least initially, an adaptive response of the heart to pressure overload but it leads to heart failure if left untreated.
Fatemeh Mirabdollahi Shamsi +3 more
doaj
Functions of p120ctn in development and disease [PDF]
, 2012 p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing.
Pieters, Tim +2 more
core +1 more source
Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer’s disease
Acta Neuropathologica Communications, 2018 One of the earliest pathological features characterizing Alzheimer’s disease (AD) is the loss of dendritic spines. Among the many factors potentially mediating this loss of neuronal connectivity, the contribution of Rho-GTPases is of particular interest.
M. Borin +15 more
semanticscholar +1 more source
LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation
Cytoskeleton, EarlyView.ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda +4 more
wiley +1 more source
Experimental study of Rac1 regulating osteoclast function in hypoxic environment
Kouqiang hemian waike zazhi[Objective:] To investigate the effect of hypoxia-inducible factor-1α (HIF-1α) on the changes of osteoclast bone resorption capacity by regulating Rac1 on cytoskeleton under hypoxic environment.
GU Jiahong, TIAN Yuanye, KANG Feiwu
doaj +1 more source
Vav1 inhibits RANKL-induced osteoclast differentiation and bone resorption [PDF]
, 2019 Vav1 is a Rho/Rac guanine nucleotide exchange factor primarily expressed in hematopoietic cells. In this study, we investigated the potential role of Vav1 in osteoclast (OC) differentiation by comparing the ability of bone marrow mononuclear cells (BMMCs)
Cha, Young-Nam +6 more
core +2 more sources
Pss knockdown in the midgut causes growth retardation in Drosophila similar to that in human LMHD
Developmental Dynamics, EarlyView.Abstract Background Phosphatidylserine synthase (PSS), localized in the mitochondrial membrane, synthesizes phosphatidylserine. In humans, mutations in Pss lead to Lenz–Majewski hyperostotic dwarfism, a disorder affecting growth and development. The effects of Pss mutations on the growth of Drosophila melanogaster are not fully known. Hence, this study
Kwan‐Young Kim +4 more
wiley +1 more source
Compact Drawings of 1-Planar Graphs with Right-Angle Crossings and Few Bends
, 2018 We study the following classes of beyond-planar graphs: 1-planar, IC-planar, and NIC-planar graphs. These are the graphs that admit a 1-planar, IC-planar, and NIC-planar drawing, respectively.
C Bachmaier +13 more
core +1 more source
Cancer Research, 2018 Shortening of the 3' untranslated regions (3'UTR) of mRNA is an important mechanism for oncogene activation. However, 3'UTR alteration events, their pathologic functions, and underlying mechanisms in human urothelial carcinoma of the bladder (UCB) are ...
Xin Chen +18 more
semanticscholar +1 more source
The role of Rho GTPases in facial morphogenesis
Developmental Dynamics, EarlyView.The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley +1 more source