Results 151 to 160 of about 2,043 (197)

Identification of Nitroxide Radioprotectors

Radiation Research, 1992
The nitroxide Tempol, a stable free radical, has recently been shown to protect mammalian cells against several forms of oxidative stress including radiation-induced cytotoxicity. To extend this observation, six additional water-soluble nitroxides with different structural features were evaluated for potential radioprotective properties using Chinese ...
S M, Hahn, L, Wilson, C M, Krishna, J, Liebmann, W, DeGraff, J, Gamson, A, Samuni, D, Venzon, J B, Mitchell   +8 more
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Clinical applications of radioprotectors

Expert Review of Anticancer Therapy, 2001
Patients with malignant or benign tumors who receive radiation therapy--frequently in combination with chemotherapy--are likely to experience side effects, either acutely or chronically. After several decades of preclinical and clinical research efforts, a first approved radioprotective drug, amifostine, has been introduced into the clinic.
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Is superoxide dismutase a physiological radioprotector

Experientia, 1979
Prolonged treatment with relatively low doses of ionizing radiation did not induce synthesis of superoxide dismutase, either in Drosophila melanogaster or in mice liver.
G, Bartosz, W, Leyko, R, Fried
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Peroxiredoxin 6 is a natural radioprotector

Doklady Biochemistry and Biophysics, 2016
After injection of 20 mg/kg peroxiredoxin 6 to male Kv:SHK mice 15 min before X-ray irradiation in the range of lethal doses (7-10 Gy), the mice remained alive for 30 days, whereas the mortality of the control animals was 100%. In the irradiated animals, peroxiredoxin 6 decreased the severity of radiation-induced leucopenia, granulocytopenia, and ...
M G, Sharapov, S V, Gudkov, A E, Gordeeva, O E, Karp, V E, Ivanov, O V, Shelkovskaya, V I, Bruskov, V I, Novoselov, E E, Fesenko   +8 more
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New and Emerging Radiosensitizers and Radioprotectors

Cancer Investigation, 2006
The combination of chemotherapy and radiation has led to clinical breakthroughs in several disease sites, and current work continues to define optimum combinations of proven chemotherapy as well as more recently available, noncytotoxic agents. Administration of systemic therapies allows modulation of radiation response to improve tumor control ...
Aaron C, Spalding, Theodore S, Lawrence
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Deoxyspergualin Is a New Radioprotector in Mice

Radiation Research, 1995
A novel immunosuppressant, deoxyspergualin, given at doses of 2.5 to 20 mg/kg/day on days -3, -2 and -1 before X irradiation protected BALB/c mice from the lethal effects of radiation in a dose-dependent manner. The dose of radiation that killed 50% of the mice within 30 days was 5.63 Gy for mice receiving radiation alone, but was 7.13 Gy in the mice ...
K, Nemoto, K, Horiuchi, T, Miyamoto
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Fullerenes as a new class of radioprotectors

International Journal of Radiation Biology, 2001
To evaluate the radioprotective activity of C3, a regioisomer of water-soluble carboxyfullerene and a potent free radical scavenger, on both normal and tumour cells.The murine committed bone-marrow stem cells for both granulocytes and monocytes (GM-CFC) were used to represent normal cells.
H S, Lin, T S, Lin, R S, Lai, T, D'Rosario, T Y, Luh   +4 more
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Behavioral toxicity of selected radioprotectors

Advances in Space Research, 1992
Effective radioprotection with minimal behavioral disruption is essential for the selection of protective agents to be used in manned spaceflight. This overview summarizes the studies on the behavioral toxicity of selected radioprotectors classified as phosphorothioates (WR-2721, WR-3689), bioactive lipids (16, 16 dimethylprostaglandin E2(DiPGE2 ...
M R, Landauer, H D, Davis, K S, Kumar, J F, Weiss   +3 more
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A New Radioprotector in Escherichia coli

Radiation Research, 1966
The procedures used in many of the experiments have been described (2, 3). In essence, the procedure used for measuring effects on nongrowing cells consists in exposing washed cells (grown in a simple glucose-salts medium and resuspended in 0.066 M phosphate buffer) to irradiation from a Co60 source (-1000 Ci, dose rate of 2.0 kR/min), with and without
R F, Pittillo, M B, Lucas, R T, Blackwell, C W, Davis   +3 more
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Interleukin 1 is a radioprotector.

The Journal of Immunology, 1986
Abstract Pretreatment with recombinant interleukin 1 (IL 1) protects mice in a dose-dependent manner from lethal effects of ionizing radiation. Two thousand units of IL 1, given i.p. 20 hr before irradiation, protect 88% of C57B1/6 mice from an LD100/17 radiation dose (dose of radiation that kills 100% mice in 17 days), and 1000 U of IL ...
R, Neta, S, Douches, J J, Oppenheim
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