Results 11 to 20 of about 88,034 (350)

RANKL and periodontitis

Folia Pharmacologica Japonica, 2023
Periodontal disease is characterized by inflammation of the periodontal tissue and subsequent destruction of the alveolar bone. It is one of the most common infectious diseases in humans, being the leading cause of tooth loss in adults. Recently, it has been shown that the receptor activator of NF-κB ligand (RANKL) produced by osteoblasts and ...
Yutaro Ando, Masayuki Tsukasaki
openalex   +4 more sources

Inhibition of RANKL-Induced Osteoclastogenesis by Novel Mutant RANKL [PDF]

International Journal of Molecular Sciences, 2021
Background: Recently, it was reported that leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4, also called GPR48) is another receptor for RANKL and was shown to compete with RANK to bind RANKL and suppress canonical RANK signaling during osteoclast differentiation.
Yuria Jang, Hong Moon Sohn, Young Jong Ko, Hoon Hyun, Wonbong Lim   +4 more
openaire   +2 more sources

OSTEOPROTEGERIN, RANK, RANKL [PDF]

Biomedical Papers, 2001
Osteoprotegerin, RANK (Receptor Activator of Nuclear factor kappa B) and RANKL (Receptor Activator of Nuclear faktor kappa B ligand) became the aim of intensive research. RANK is considered as a hematopoietic surface receptor controlling osteoclastogenesis and calcium metabolism.
D, Stejskal, J, Bartek, R, Pastorková, V, Růzicka, I, Oral, D, Horalík   +5 more
openaire   +2 more sources

Effect of Low-magnitude, High-frequency Vibration on Osteocytes in the Regulation of Osteoclasts [PDF]

, 2010
Osteocytes are well evidenced to be the major mechanosensor in bone, responsible for sending signals to the effector cells (osteoblasts and osteoclasts) that carry out bone formation and resorption. Consistent with this hypothesis, it has been shown that
Al-Dujaili, Saja, Guenther, Axel, Lau, Esther, Liu, Dawei, Wang, Liyun, You, Lidan   +5 more
core   +2 more sources

OPG/RANKL [PDF]

médecine/sciences, 2008
Given the increasing risk of fractures with aging in western countries, there is a need for the development of safe and efficient anti-osteoporotic drugs for the prevention and treatment of osteoporosis. Recent studies have provided evidence for an essential role of RANKL (Receptor Activator of Nuclear Factor-kappa B Ligand) and its decoy receptor ...
Pierre Marie, Philippe Halbout
openaire   +1 more source

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]

, 2017
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Abu-Amer, Yousef, Alippe, Yael, Civitelli, Roberto, Mbalaviele, Gabriel, Novack, Deborah V, Qu, Chao, Ricci, Biancamaria, Wang, Chun, Xiao, Jianqiu, Zou, Wei   +9 more
core   +2 more sources

M CELLS ARE THE IMPORTANT POST IN THE INITIATION OF IMMUNE RESPONSE IN INTESTINE

Инфекция и иммунитет, 2018
Microfold cells (M cells) are specialized intestinal epithelial cells that initiate mucosal immune responses. These unique phagocytic epithelial cells are specialized for the transfer of a broad range of particulate antigens and microorganisms across the
A. S. Bykov, A. V. Karaulov, D. A. Tsomartova, N. L. Kartashkina, V. L. Goriachkina, S. L. Kuznetsov, D. A. Stonogina, Ye. V. Chereshneva   +7 more
doaj   +1 more source

Inhibition of RANK signaling as a potential immunotherapy in breast cancer

OncoImmunology, 2021
RANK signaling in mouse mammary tumor cells exerts an immunosuppressive environment by promoting the infiltration of pro-tumorigenic neutrophils and preventing CD8 T cell recruitment.
C Gómez-Aleza, E González-Suárez
doaj   +1 more source

Osteoclast activity in osteoporosis mandibular bone based on RANKL and osteoprotegerin ratio. [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2021
Context: Osteoporosis occurs not only in the lumbar bone, femur, and radius but also occurs in the mandibular bone. Therefore, osteoporosis is a disease that required attention from the dentists.
Mefina Kuntjoro, Nike Hendrijantini, Fedik Abdul Rantam, Guang Hong, Sherman Salim, Muhammad Dimas Aditya Ari   +5 more
doaj  

Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity [PDF]

, 2017
Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1-mediated Cre expression is a useful strategy to genetically manipulate the mouse prostate. While grossly normal at birth, we observed
Ahmad, Imran, Blyth, Karen, Charlesworth, Gemma, Daroszewska, Anna, Ford, Catriona, King, Ayala, Leung, Hing Y., Loveridge, Carolyn J., Mui, Ernest J., Prior, Amanda, Rose, Lorraine, Salji, Mark, Sansom, Owen, Tan, Ee Hong, van ’t Hof, Rob J., Welsh, Michelle   +15 more
core   +2 more sources