Results 11 to 20 of about 41,957 (263)
Inhibition of RANKL-Induced Osteoclastogenesis by Novel Mutant RANKL [PDF]
International Journal of Molecular Sciences, 2021 Background: Recently, it was reported that leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4, also called GPR48) is another receptor for RANKL and was shown to compete with RANK to bind RANKL and suppress canonical RANK signaling during osteoclast differentiation.
Yuria Jang +4 more
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Gerontology, 2015 Receptor activator of nuclear factor κB (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulation of the central nervous system. RANKL
Vanja, Nagy, Josef M, Penninger
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Targeting RANKL in metastasis [PDF]
BoneKEy Reports, 2014 Acting through its cognate receptor, receptor activator of nuclear factor-κB (RANK), RANK ligand (RANKL) is an essential mediator of osteoclast function and survival. Preclinical data have now firmly established that blockade of tumor-induced osteoclastogenesis by RANKL inhibition will not only protect against bone destruction but will also inhibit the
Dougall, W.C. +2 more
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OSTEOPROTEGERIN, RANK, RANKL [PDF]
Biomedical Papers, 2001 Osteoprotegerin, RANK (Receptor Activator of Nuclear factor kappa B) and RANKL (Receptor Activator of Nuclear faktor kappa B ligand) became the aim of intensive research. RANK is considered as a hematopoietic surface receptor controlling osteoclastogenesis and calcium metabolism.
D, Stejskal +5 more
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Osteopetrosis rescue upon RANKL administration to Rankl−/− mice: A new therapy for human RANKL-dependent ARO [PDF]
Journal of Bone and Mineral Research, 2012 Abstract In the last decades the molecular basis of monogenic diseases has been largely unraveled, although their treatment has often remained unsatisfactory. Autosomal recessive osteopetrosis (ARO) belongs to the small group of genetic diseases that are usually treated with hematopoietic stem cell transplantation (HSCT).
LO IACONO N +21 more
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médecine/sciences, 2008 Given the increasing risk of fractures with aging in western countries, there is a need for the development of safe and efficient anti-osteoporotic drugs for the prevention and treatment of osteoporosis. Recent studies have provided evidence for an essential role of RANKL (Receptor Activator of Nuclear Factor-kappa B Ligand) and its decoy receptor ...
Pierre Marie, Philippe Halbout
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RANK–RANKL signalling in cancer [PDF]
Bioscience Reports, 2016 Oncogenic events combined with a favourable environment are the two main factors in the oncological process. The tumour microenvironment is composed of a complex, interconnected network of protagonists, including soluble factors such as cytokines, extracellular matrix components, interacting with fibroblasts, endothelial cells, immune cells and various
Heymann, D. +4 more
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Osteoclast activity in osteoporosis mandibular bone based on RANKL and osteoprotegerin ratio. [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2021 Context: Osteoporosis occurs not only in the lumbar bone, femur, and radius but also occurs in the mandibular bone. Therefore, osteoporosis is a disease that required attention from the dentists.
Mefina Kuntjoro +5 more
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Regulation of neurite growth by tumour necrosis superfamily member RANKL [PDF]
Open Biology, 2013 RANKL (receptor-activator of NF-κB ligand, TNFSF11) is a member of the TNF superfamily that regulates bone remodelling and the development of the thymus, lymph nodes and mammary glands.
Humberto Gutierrez +5 more
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陆军军医大学学报, 2023 Objective To investigate the mechanisms of 1, 25(OH)2D3 on joint inflammation and bone destruction in a mouse model of collagen-induced arthritis (CIA). Methods Thirty DBA/1J mice were equally allocated into control, CIA and intervention (VD) groups. The
QI Kun, LIU Yun, TANG Tao, LUO Xiwen
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