Results 11 to 20 of about 41,691 (265)
Inhibition of RANKL-Induced Osteoclastogenesis by Novel Mutant RANKL [PDF]
International Journal of Molecular Sciences, 2021 Background: Recently, it was reported that leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4, also called GPR48) is another receptor for RANKL and was shown to compete with RANK to bind RANKL and suppress canonical RANK signaling during osteoclast differentiation.
Yuria Jang +4 more
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ارتباط بین غلظت سرمیRANKL با اختلالات قلبی در بیماران بتا تالاسمی ماژور [PDF]
Majallah-i Dānishkadah-i Pizishkī-i Dānishgāh-i ̒ Ulūm-i Pizishkī-i Mashhad., 2020 چکیده مقدمه: بتا تالاسمی ماژور نوعی اختلال اتوزومال مغلوب است که با اریتروپوئز غیر موثر شناخته میشود. تزریق مداوم و ناتوانی بدن در حذف آهن در بدن منجر به اضافه بار آهن شده که باعث ایجاد صدمه به بافت قلب میشود.
الهام محمودی +5 more
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Bad to the bone: B cell acute lymphoblastic leukemia cells mediate bone destruction
Molecular & Cellular Oncology, 2021 Skeletal morbidities continue to cause acute and long-term burdens for B-ALL patients underscoring the need to identify the mechanisms underlying these processes and to develop effective therapies.
Sujeetha A. Rajakumar, Jayne S. Danska
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Piceatannol attenuates RANKL-induced osteoclast differentiation and bone resorption by suppressing MAPK, NF-κB and AKT signalling pathways and promotes Caspase3-mediated apoptosis of mature osteoclasts [PDF]
Royal Society Open Science, 2019 Osteoclasts are multinuclear giant cells that have unique ability to degrade bone. The search for new medicines that modulate the formation and function of osteoclasts is a potential approach for treating osteoclast-related bone diseases.
Liuliu Yan +4 more
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Gerontology, 2015 Receptor activator of nuclear factor κB (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulation of the central nervous system. RANKL
Vanja, Nagy, Josef M, Penninger
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Molecules, 2020 Receptor activator of nuclear factor-κB ligand (RANKL) is a cytokine responsible for bone resorption. It binds its receptor RANK, which activates osteoporosis.
Małgorzata Zakłos-Szyda +4 more
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Targeting RANKL in metastasis [PDF]
BoneKEy Reports, 2014 Acting through its cognate receptor, receptor activator of nuclear factor-κB (RANK), RANK ligand (RANKL) is an essential mediator of osteoclast function and survival. Preclinical data have now firmly established that blockade of tumor-induced osteoclastogenesis by RANKL inhibition will not only protect against bone destruction but will also inhibit the
Dougall, W.C. +2 more
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Research progress on the relationship between osteocytes and periodontitis
口腔疾病防治, 2020 Osteocytes, which develop from osteoblasts, are recognized as the main cells embedded in mature bone tissue. The traditional notion is that osteocytes exclusively play a structural role, however, with the development of related research in recent years ...
ZHU Xuanzhi +3 more
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OSTEOPROTEGERIN, RANK, RANKL [PDF]
Biomedical Papers, 2001 Osteoprotegerin, RANK (Receptor Activator of Nuclear factor kappa B) and RANKL (Receptor Activator of Nuclear faktor kappa B ligand) became the aim of intensive research. RANK is considered as a hematopoietic surface receptor controlling osteoclastogenesis and calcium metabolism.
D, Stejskal +5 more
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Medienkompetenzvermittlung im Fachgegenstand Musikerziehung
Medienimpulse, 2014 Dieser Artikel befasst sich mit der Integration von Medienbildung in den Musikunterricht und behandelt Aspekte inwieweit musikerzieherische Inhalte auch zur Medienbildung beitragen können.
Martin Rankl
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