Results 191 to 200 of about 41,691 (265)

Reciprocal Macrophage‐MSC Crosstalk Drives Immunomodulatory and Regenerative Phenotypes in a Mineralized Collagen Scaffold

Journal of Biomedical Materials Research Part A, Volume 114, Issue 6, June 2026.
Macrophage‐MSC interactions are dynamic. Following injury, neutral (M0) macrophages arrive at the defect site and polarize towards M1 (pro‐inflammatory) macrophages, which can secrete inflammatory and cell recruitment factors. MSCs in this inflammatory defect can take on a licensed state in which they secrete a series of immunomodulatory factors that ...
Vasiliki Kolliopoulos, Maxwell Polanek, Hashni E. Vidana Gamage, Melisande Wong Yan Ling, Aleczandria Tiffany, Erik R. Nelson, Kara L. Spiller, Brendan A. C. Harley   +7 more
wiley   +1 more source

Estrogen and progesterone-mediated differential modulation of CD4⁺ T-cell pathogenicity in rheumatoid arthritis. [PDF]

Front Immunol
Jha R, Shaw SK, Bhattacharya G, Behera H, Pattanaik C, Sengupta S, Barik PK, Parida JR, Padhan P, Devadas S.   +9 more
europepmc   +1 more source

Controversies Surrounding Critical‐Size Defects: Influence of Age and Biological Characteristics

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 6, June 2026.
ABSTRACT Critical‐size defects (CSDs) in craniofacial reconstruction refer to osseous gaps that fail to heal spontaneously, increasing the risk of neurological impairment and craniofacial dysmorphology. Despite decades of investigation, controversy still exists surrounding the definition of CSDs, with criteria varying across species, experimental ...
Andrew Nordlund, Hana Shah, Nicholas A. Mirsky, Kashyap K. Tadisina, Arturo J. Rios‐Diaz, Vasudev Vivekanand Nayak, Estevam A. Bonfante, Paulo G. Coelho   +7 more
wiley   +1 more source

RANKL Attenuates Sepsis-Associated Acute Lung Injury Through the OPG/RANKL/RANK/TLR4 Pathway. [PDF]

Immun Inflamm Dis
Niu X, Turson N, Chen W, Li H.
europepmc   +1 more source

Gastric Cancer: Pathobiology and Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu, Miao Zhang, Yan Meng, Chunxiao Zhu, Weihong Zhang, Hui Zhang, Zhifa Cao, Meihang Du, Zhangting Zhao, Junping Bai, Yi Han, Yang Tang, Wei Kang, Ka Fai To, Shi Jiao, Liwei An, Zhaocai Zhou   +16 more
wiley   +1 more source

Porphyromonas gingivalis outer membrane vesicles promote alveolar bone resorption by increasing the local RANKL/OPG ratio in experimental periodontitis model rats. [PDF]

Sci Rep
Nakamura D, Inagaki Y, Uemura Y, Hiroshima Y, Iwata Y, Kido R, Bando M, Sumitomo T, Yumoto H.   +8 more
europepmc   +1 more source

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, Volume 7, Issue 3, June 2026.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

Titanium Dioxide Particle Size Influences Macrophage Signal Switch Towards Osteogenesis In Vitro. [PDF]

Int Dent J
Aghila Rani KG, Rizvi Z, Suresh S, Samsudin AR, AlKawas S, Kheder W.   +5 more
europepmc   +1 more source

Abnormal Stress Reduced miR‐330 Supplementation Alleviates Osteoarthritis Progression by Suppressing Osteochondral Catabolism

Aging Cell, Volume 25, Issue 6, June 2026.
Downregulation of miR‐330 under abnormal stress exacerbates catabolism in cartilage and subchondral bone, thereby promoting the progression of osteoarthritis. ABSTRACT Abnormal mechanical stress plays a crucial role in the progression of osteoarthritis (OA). Key factors regulating mechanical response remain to be explored. This study harvested synovium
Luxiang Zou, Kaiwen Yang, Chuyao Wang, Yeke Yu, Xiaoyu Zhang, Chuan Lu, Jieyun Zhao, An Qin, Dongmei He   +8 more
wiley   +1 more source